Zobrazeno 1 - 10 of 64 pro vyhledávání: '"George A. Boswell"'
1
Steroidal nitrone inhibitors of 5α-reductase
Autor: Spencer Drummond, George A. Boswell, Indawati Delucca, Andrea J. Robinson
Publikováno v: Tetrahedron Letters. 44:4801-4804
This paper describes the rational design and synthesis of novel inhibitors of human steroid 5α-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5α-redu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c20e65870d921c733f1145832212e51d
https://doi.org/10.1016/s0040-4039(03)00741-x
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2
George Marion Boswell, Jr., MD: A Conversation with the Editor
Autor: William Clifford Roberts, George Marion Boswell
Publikováno v: Baylor University Medical Center Proceedings. 15:275-288
George Boswell (Figure ​(Figure11) was born near Grand Prairie, Texas, on May 12, 1920. He grew up in Texas, primarily in the Dallas area (Figures ​(Figures22 and ​and33). After finishing high school at age 15, he went to McMurry College for 2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57e931eeca99902e44cec27399f18d0f
https://doi.org/10.1080/08998280.2002.11927854
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3
THE CHARACTERIZATION OF POTENT NOVEL WARFARIN ANALOGS
Autor: Janet S Kerr, Andrea J. Robinson, Candy Robinson, Hui-Yin Li, Roseanne S Wexler, George A. Boswell, Candice M. Krauthauser, Patricia P Harlow
Publikováno v: Thrombosis Research. 88:127-136
Racemic sodium warfarin, Coumadin,® is widely used in the prevention of thromboembolic disease. The present study was undertaken to characterize three novel classes of warfarin analogs, and to compare them with the warfarin enantiomers. All three cl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ac65442485854a4bf48d00649aaaea
https://doi.org/10.1016/s0049-3848(97)00224-7
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4
Design, synthesis and structure-activity relationship studies of novel 4,4-bis(trifluoromethyl)imidazolines as acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents
Autor: Spencer Drummond, George A. Boswell, Candy Robinson, Hui-Yin Li, Peter J. Gillies, Jeffrey T. Billheimer, Indawati Delucca
Publikováno v: Bioorganic & Medicinal Chemistry. 5:1345-1361
Novel 4,4-bis(trifluoromethyl)imidazolines have been found to be the potent acyl-CoA cholesterol acyltransferase (ACAT) inhibitors. ACAT is responsible for cholesterol esterification in the intestine, liver, and the arterial wall. These novel imidazo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7434ea6261df1bf049dcdf56be5ecc
https://doi.org/10.1016/s0968-0896(97)00058-8
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5
Asymmetric synthesis and absolute stereochemistry of 4,4-bis-(trifluoromethyl)imidazoline based ACAT inhibitors
Autor: I. Delucca, Spencer Drummond, Hui-Yin Li, George A. Boswell
Publikováno v: Tetrahedron. 53:5359-5372
An asymmetric synthesis of 1, a potent orally active ACAT inhibitor, is reported. The absolute configuration of 1 has been determined by exciton CD spectra and X-ray crystal structure analysis.
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https://doi.org/10.1016/s0040-4020(97)00081-1
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6
A facile synthesis of fluorinated 4-hydroxycoumarins
Autor: Hui-Yin Li, George A. Boswell
Publikováno v: Tetrahedron Letters. 37:1551-1554
Fluorinated 4-hydroxycoumarins were prepared from readily available fluorinated phenols via a AlCl3 catalyzed Friedel-Crafts ring closure and followed by sequential one pot decarboxylation and deacetylation with 90% H2SO4.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb5c216de95ebce67e0eaf28b703a91e
https://doi.org/10.1016/0040-4039(96)00101-3
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7
Imidazolinones as nonpeptide angiotensin II receptor antagonists
Autor: Pancras C. Wong, Inda DeLucca, Ruth R. Wexler, Pieter B.M.W.M. Timmermans, George A. Boswell, Andrew T. Chiu, Mimi L. Quan
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:1527-1530
A series of biphenyl imidazolinones were synthesized as nonpeptide angiotensin II receptor antagonists. While those compounds with a tetrazole functionality were found to be AT 1 selective, those with a sulfonamide moiety showed affinities for both t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa45506fd17ac54165e882b7175d8702
https://doi.org/10.1016/s0960-894x(01)80526-6
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8
Fluorination by Sulfur Tetrafluoride
Autor: R. M. Scribner, George A. Boswell, W. C. Ripka, C. W. Tullock
Publikováno v: Organic Reactions
Although sulfur tetrafluoride is a remarkably versatile agent for selectively introducing fluorine atoms into organic compounds, its existence was doubted as late as 1950. A colorless gas boiling at -38o C, sulfur tetrafluoride was probably first mad
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https://doi.org/10.1002/0471264180.or021.01
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9
ChemInform Abstract: A Facile Synthesis of Fluorinated 4-Hydroxycoumarins
Autor: Hui-Yin Li, George A. Boswell
Publikováno v: ChemInform. 27
Fluorinated 4-hydroxycoumarins were prepared from readily available fluorinated phenols via a AlCl3 catalyzed Friedel-Crafts ring closure and followed by sequential one pot decarboxylation and deacetylation with 90% H2SO4.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf0eb1dffff48a814da0bd2a0b808f65
https://doi.org/10.1002/chin.199625132
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