Zobrazeno 1 - 10
of 60
pro vyhledávání: '"George A. Belov"'
Publikováno v:
Virus Research, Vol 341, Iss , Pp 199309- (2024)
Newcastle disease virus (NDV) is an avian virus and a promising vector for the development of vaccines for veterinary and human use. The optimal vaccine vector performance requires a stable high-level expression of a transgene. The foreign genes are
Externí odkaz:
https://doaj.org/article/20c42b5747184ad5897f8619b6577a7b
Autor:
Justyna M. Meissner, Katarina Akhmetova, Tomasz Szul, Ekaterina G. Viktorova, Bingdong Sha, Jay M. Bhatt, Eunjoo J. Lee, Richard A. Kahn, George A. Belov, Igor Chesnokov, Elizabeth Sztul
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Golgi homeostasis require the activation of Arf GTPases by the guanine-nucleotide exchange factor requires GBF1, whose recruitment to the Golgi represents a rate limiting step in the process. GBF1 contains a conserved, catalytic, Sec7 domain (Sec7d)
Externí odkaz:
https://doaj.org/article/47ad1c1941594ac4be6883a193b4801f
Autor:
Piero Giansanti, Jeroen R. P. M. Strating, Kyra A. Y. Defourny, Ieva Cesonyte, Alexia M. S. Bottino, Harm Post, Ekaterina G. Viktorova, Vien Quang Tri Ho, Martijn A. Langereis, George A. Belov, Esther N. M. Nolte-‘t Hoen, Albert J. R. Heck, Frank J. M. van Kuppeveld
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Here, Giansanti et al. perform a system-wide and time-resolved characterization of the changes in the host cell proteome and phosphoproteome of cells infected with the enterovirus coxsackievirus B3 during a full round of replication and identify mTOR
Externí odkaz:
https://doaj.org/article/f6c324bdfe0e47ba949b2bdd1df1f91a
Autor:
Anna Zimina, Ekaterina G. Viktorova, Seyedehmahsa Moghimi, Jules Nchoutmboube, George A. Belov
Publikováno v:
Viruses, Vol 13, Iss 8, p 1587 (2021)
The capsid precursor P1 constitutes the N-terminal part of the enterovirus polyprotein. It is processed into VP0, VP3, and VP1 by the viral proteases, and VP0 is cleaved autocatalytically into VP4 and VP2. We observed that poliovirus VP0 is recognize
Externí odkaz:
https://doaj.org/article/9a9046805704497eb6bfcc3ca8901377
Autor:
Zhenlu Zhang, Guijuan He, Natalie A. Filipowicz, Glenn Randall, George A. Belov, Benjamin G. Kopek, Xiaofeng Wang
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Membrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitabl
Externí odkaz:
https://doaj.org/article/d3da6809f2f24909b8d31bebde299d65
Autor:
George A. Belov
Publikováno v:
Viruses, Vol 7, Iss 7, Pp 3500-3505 (2015)
All positive strand RNA viruses of eukaryotes replicate their genomes in association with membranes. These viruses actively change cellular lipid metabolism to build replication membranes enriched in specific lipids. The ubiquitous use of membranes b
Externí odkaz:
https://doaj.org/article/b74387cff3a94e04a89b6f8332cdfcfc
Publikováno v:
Viruses, Vol 10, Iss 10, p 559 (2018)
The high human cost of Zika virus infections and the rapid establishment of virus circulation in novel areas, including the United States, present an urgent need for countermeasures against this emerging threat. The development of an effective vaccin
Externí odkaz:
https://doaj.org/article/ba1abeb5c38b48829fc44d5c039b06d0
Autor:
Ekaterina G. Viktorova, Samuel Gabaglio, Seyedehmahsa Moghimi, Anna Zimina, Bridge G. Wynn, Elizabeth Sztul, George A. Belov
The cellular protein GBF1, an activator of Arf GTPases (ArfGEF: Arf guanine nucleotide exchange factor), is recruited to the replication organelles of enteroviruses through interaction with the viral protein 3A, and its ArfGEF activity is required fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af4aa379839797b65c7e69d4a1e8f1ba
https://doi.org/10.1101/2023.05.09.539905
https://doi.org/10.1101/2023.05.09.539905
Autor:
Seyedehmahsa Moghimi, Ekaterina G. Viktorova, Samuel Gabaglio, Anna Zimina, Bogdan Budnik, Bridge G. Wynn, Elizabeth Sztul, George A. Belov
Publikováno v:
PLoS pathogens. 18(10)
As ultimate parasites, viruses depend on host factors for every step of their life cycle. On the other hand, cells evolved multiple mechanisms of detecting and interfering with viral replication. Yet, our understanding of the complex ensembles of pro
Publikováno v:
J Gen Virol
Newcastle disease virus (NDV) has been extensively explored as a vector for vaccine and oncolytic therapeutic development. In conventional NDV-based vectors, the transgene is arranged as a separate transcription unit in the NDV genome. Here, we expre