Zobrazeno 1 - 10
of 160
pro vyhledávání: '"George A Mackie"'
Autor:
Gyles Ifill, Travis Blimkie, Amy Huei-Yi Lee, George A. Mackie, Qing Chen, Scott Stibitz, Robert E. W. Hancock, Rachel C. Fernandez
Publikováno v:
mSphere, Vol 6, Iss 4 (2021)
Noncoding, regulatory RNAs in bacterial pathogens are critical components required for rapid changes in gene expression profiles. However, little is known about the role of regulatory RNAs in the growth and pathogenesis of Bordetella pertussis
Externí odkaz:
https://doaj.org/article/7cbaf5dae8cc434db41c923c54f95068
Autor:
Rachel C. Fernandez, George A Mackie, Gyles Ifill, Qing Chen, Robert E. W. Hancock, Amy S. Lee, Travis M. Blimkie, Scott Stibitz
Publikováno v:
mSphere
mSphere, Vol 6, Iss 4 (2021)
mSphere, Vol 6, Iss 4 (2021)
Bordetella pertussis has been shown to encode regulatory RNAs, yet the posttranscriptional regulatory circuits on which they act remain to be fully elucidated. We generated mutants lacking the endonucleases RNase III and RNase E and assessed their in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ede0927bda4f1bfef731fe4e2d7df75
https://pubmed.ncbi.nlm.nih.gov/34406853
https://pubmed.ncbi.nlm.nih.gov/34406853
Publikováno v:
Journal of Bacteriology. 197:477-482
RNase E is a major intracellular endoribonuclease in many bacteria and participates in most aspects of RNA processing and degradation. RNase E requires a divalent metal ion for its activity. We show that only Mg2+and Mn2+will support significant rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcbe4069768859ae30ac9a1db33755f
https://doi.org/10.1128/jb.02372-14
https://doi.org/10.1128/jb.02372-14
Autor:
George A. Mackie
Publikováno v:
Molecular Microbiology. 89:388-402
RNase E plays a central role in processing virtually all classes of cellular RNA in many bacterial species. A characteristic feature of RNase E and its paralogue RNase G, as well as several other unrelated ribonucleases, is their preference for 5'-mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::744569231e4e976a50d7860f270c24ca
https://doi.org/10.1111/mmi.12283
https://doi.org/10.1111/mmi.12283
Publikováno v:
Canadian Journal of Zoology. 90:172-181
Contact of food with the manubrial lips in the genus Polyorchis A. Agassiz, 1862 evokes trains of electrical impulses (E potentials) that propagate to the margin. E potentials are also produced by food stimuli at the margin and tentacle bases. E pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6e93e6ea7515a37fb9e92e62c6a865a
https://doi.org/10.1139/z11-124
https://doi.org/10.1139/z11-124
Autor:
Stephen M. Garrey, George A. Mackie
Publikováno v:
Molecular Microbiology. 80:1613-1624
Viable mutations affecting the 5'-phosphate sensor of RNase E, including R169Q or T170A, become lethal when combined with deletions removing part of the non-catalytic C-terminal domain of RNase E. The phosphate sensor is required for efficient autore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a806a01e7934ce2f91ccf91fbfc84b13
https://doi.org/10.1111/j.1365-2958.2011.07670.x
https://doi.org/10.1111/j.1365-2958.2011.07670.x
Autor:
Stephen M. Garrey, Jenna L. Riffell, Janet S. Hankins, Ying-Han Roger Hsu, George A. Mackie, Melinda M. Diver, Michaela Blech, Vitharani Kunanithy, Leigh M. Stickney
Publikováno v:
Journal of Biological Chemistry. 284:31843-31850
The paralogous endoribonucleases, RNase E and RNase G, play major roles in intracellular RNA metabolism in Escherichia coli and related organisms. To assay the relative importance of the principal RNA binding sites identified by crystallographic anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afc2c31468b4234e17d75213fd38c37b
https://doi.org/10.1074/jbc.m109.063263
https://doi.org/10.1074/jbc.m109.063263
Autor:
Robert W Meech, George O. Mackie
Publikováno v:
Invertebrate Neuroscience. 8:199-209
N eoturris breviconis (Anthomedusae) has a nerve plexus in the walls of its endodermal canals. The plexus is distinct from the ectodermal nerve plexuses supplying the radial and circular muscles in the ectoderm and no connections have been observed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48c857f1f43be83dd36216581f069bb
https://doi.org/10.1007/s10158-008-0082-6
https://doi.org/10.1007/s10158-008-0082-6
Publikováno v:
Journal of Bacteriology. 189:4353-4358
Degradation of the cspA mRNA in vivo is very rapid at temperatures greater than 30°C and is moderately dependent on RNase E. Investigations in vitro show that degradosomes prepared from normal or cold-shocked cultures cleave the cspA mRNA preferenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af574ff98154a5ac7a06f7c193eaac47
https://doi.org/10.1128/jb.00193-07
https://doi.org/10.1128/jb.00193-07
Publikováno v:
Journal of Bacteriology. 187:7214-7221
We have examined the roles of the conserved S1 and KH RNA binding motifs in the widely dispersed prokaryotic exoribonuclease polynucleotide phosphorylase (PNPase). These domains can be released from the enzyme by mild proteolysis or by truncation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5620b496d9dd28c2582a555cd31b8f
https://doi.org/10.1128/jb.187.21.7214-7221.2005
https://doi.org/10.1128/jb.187.21.7214-7221.2005