Zobrazeno 1 - 10
of 31
pro vyhledávání: '"George A Heavner"'
Autor:
Basant Sharma, Srinivas R. Gunturi, Mary Ryan, Michael Brigham-Burke, George A. Heavner, Mary F. Shanahan, Frank McMahon, Francis Farrell
Publikováno v:
International Immunopharmacology. 6:647-655
The incidence of pure red cell aplasia (PRCA) in patients with chronic kidney disease associated with the subcutaneous (s.c.) administration of epoetin alfa (EPREX®) began to increase in 1998. As part of an intensive investigation into the reasons f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb648b460264fc97a84148765911183
https://doi.org/10.1016/j.intimp.2005.10.001
https://doi.org/10.1016/j.intimp.2005.10.001
Publikováno v:
Pharmaceutical Research. 22:1186-1194
The cause of antibody positive pure red cell aplasia associated with the subcutaneous administration of EPREX® to patients with chronic kidney failure has been determined to be due to the leaching of weakly adjuvant compounds from the uncoated rubbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6031a515935ef253851128f187bbb3
https://doi.org/10.1007/s11095-005-5356-7
https://doi.org/10.1007/s11095-005-5356-7
Autor:
Natalia N Nashkevich, George A Heavner, Nikolai N. Voitenok, Svetlana Akalovich, Natalia Louneva
Publikováno v:
Journal of Immunological Methods. 270:37-51
Interleukin-8 (IL-8) plays a central role in neutrophil chemotaxis and exerts a wide range of effects on various cells, ranging from tumor angiogenesis to impairment of neuronal signaling. Two main forms of IL-8 exist, one containing 77 amino acids (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31c6e56b2578a42c150a4be2b88c305
https://doi.org/10.1016/s0022-1759(02)00279-x
https://doi.org/10.1016/s0022-1759(02)00279-x
Structure–Function Studies on Synthetic Peptides Derived from the 109–118 Lectin Domain of Selectins
Autor:
Susan H. Tam, Miljenko Mervic, Marian T. Nakada, Alexander H. Taylor, Marian Kruszynski, George A. Heavner, William E. Fieles
Publikováno v:
Biochemical and Biophysical Research Communications. 227:712-717
Previously, we identified several peptides corresponding to amino acid sequences within the lectin domains of selectins that inhibit neutrophil (PMN) adhesion to P-selectin. Here we focused on one of the active regions, 109-118, which contains residu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0c47f0fa0e28c00f416f481d46ec8d
https://doi.org/10.1006/bbrc.1996.1574
https://doi.org/10.1006/bbrc.1996.1574
Autor:
George A. Heavner
Publikováno v:
Drug Discovery Today. 1:295-304
The adhesion of cells to molecules of the extracellular matrix or to other cells is basic to many biological processes, including cell growth, cell trafficking, wound healing, metastasis, formation of tissue architecture, regulation of the immune sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13bf0aec1f4a3e7c599052fa71447034
https://doi.org/10.1016/1359-6446(96)10027-1
https://doi.org/10.1016/1359-6446(96)10027-1
Autor:
George R. Heavner
Publikováno v:
Fresenius' Journal of Analytical Chemistry. 352:19-22
Significant progress has been made with the introduction of new AOAC INTERNATIONAL programs since plans were announced at BERM-5 in Aachen, Germany. The AOAC® Technical Division on Reference Materials has been formed, the AOAC® Peer-Verified Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e5170384467645309d570c907fa3984
https://doi.org/10.1007/bf00322288
https://doi.org/10.1007/bf00322288
Publikováno v:
Journal of molecular recognition : JMR. 25(3)
There are a number of proteins whose active forms are non-covalent multichain complexes. Therapeutic intervention involving such complexes has been proposed through the use of muteins to form heterostructures. These resulting structures would either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0f37ff7382977da6a08abd75acaa17c
https://pubmed.ncbi.nlm.nih.gov/22407981
https://pubmed.ncbi.nlm.nih.gov/22407981
Autor:
David Peritt, Jacqueline Benson, Jill Giles-Komar, Bernard J. Scallon, David J. Shealy, George A. Heavner, Mary Ann Mascelli
Publikováno v:
mAbs. 3(6)
Monoclonal antibody (mAb) therapy was first established upon the approval of a mouse antibody for treatment of human acute organ rejection. However, the high incidence of immune response against the mouse mAb restricted therapeutic utility. Developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124f9a410b7631d3c474d1c004cd74e7
https://pubmed.ncbi.nlm.nih.gov/22123062
https://pubmed.ncbi.nlm.nih.gov/22123062
Autor:
Jinquan Luo, Eilyn R. Lacy, Audrey Baker, Yevgeniya I. Orlovsky, Jacqueline Benson, Galina Obmolova, Alexey Teplyakov, Sheng-Jiun Wu, Hans-Thomas Richter, George A. Heavner
Publikováno v:
Journal of molecular biology. 402(5)
Interleukin (IL)-12 and IL-23 are heterodimeric proinflammatory cytokines that share a common p40 subunit, paired with p35 and p19 subunits, respectively. They represent an attractive class of therapeutic targets for the treatment of psoriasis and ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120efebcc7494bf6ac354986c1869427
https://pubmed.ncbi.nlm.nih.gov/20691190
https://pubmed.ncbi.nlm.nih.gov/20691190
Publikováno v:
Journal of Biological Chemistry. 267:19846-19853
Selectins are receptors that mediate leukocyte adhesion to platelets or endothelial cells through Ca(2+)-dependent interactions with cell surface oligosaccharides. We found that peptides corresponding to residues 23-30, 54-63, and 70-79 of the N-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::551b466fae7029411755b79da1495295
https://doi.org/10.1016/s0021-9258(19)88632-5
https://doi.org/10.1016/s0021-9258(19)88632-5