Zobrazeno 1 - 10
of 74
pro vyhledávání: '"George A Garinis"'
Publikováno v:
Frontiers in Genetics, Vol 7 (2016)
To lessen the wear and tear of existence, cells have evolved mechanisms that continuously sense DNA lesions, repair DNA damage and restore the compromised genome back to its native form. Besides genome maintenance pathways, multi-cellular organisms m
Externí odkaz:
https://doaj.org/article/64853ace23f24b35885d07caa57f8ca9
Autor:
W Edward Visser, Cíntia R Bombardieri, Chantal Zevenbergen, Sander Barnhoorn, Alexandre Ottaviani, Ingrid van der Pluijm, Renata Brandt, Ellen Kaptein, Ramona van Heerebeek, Hans van Toor, George A Garinis, Robin P Peeters, Marco Medici, Willy van Ham, Wilbert P Vermeij, Monique C de Waard, Ronald R de Krijger, Anita Boelen, Joan Kwakkel, John J Kopchick, Edward O List, Joost P M Melis, Veerle M Darras, Martijn E T Dollé, Gijsbertus T J van der Horst, Jan H J Hoeijmakers, Theo J Visser
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149941 (2016)
DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key regulator of
Externí odkaz:
https://doaj.org/article/ca420b0d4f254e4db9aa43c0a8d08565
Autor:
Athanasios Siametis, Kalliopi Stratigi, Despoina Giamaki, Georgia Chatzinikolaou, Alexia Akalestou-Clocher, Evi Goulielmaki, Brian Luke, Björn Schumacher, George A. Garinis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Transcription stress has been linked to DNA damage -driven aging, yet the underlying mechanism remains unclear. Here, we demonstrate that Tcea1 −/− cells, which harbor a TFIIS defect in transcription elongation, exhibit RNAPII stalling a
Externí odkaz:
https://doaj.org/article/2f9a3ba235c547c3a40c9057511756df
Autor:
Ingrid van der Pluijm, George A Garinis, Renata M. C Brandt, Theo G. M. F Gorgels, Susan W Wijnhoven, Karin E. M Diderich, Jan de Wit, James R Mitchell, Conny van Oostrom, Rudolf Beems, Laura J Niedernhofer, Susana Velasco, Errol C Friedberg, Kiyoji Tanaka, Harry van Steeg, Jan H. J Hoeijmakers, Gijsbertus T. J van der Horst
Publikováno v:
PLoS Biology, Vol 6, Iss 11 (2008)
Externí odkaz:
https://doaj.org/article/2ccd9740047843849d12820a3da5e1fb
Autor:
Björn Schumacher, Ingrid van der Pluijm, Michael J Moorhouse, Theodore Kosteas, Andria Rasile Robinson, Yousin Suh, Timo M Breit, Harry van Steeg, Laura J Niedernhofer, Wilfred van Ijcken, Andrzej Bartke, Stephen R Spindler, Jan H J Hoeijmakers, Gijsbertus T J van der Horst, George A Garinis
Publikováno v:
PLoS Genetics, Vol 4, Iss 8, p e1000161 (2008)
Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity,
Externí odkaz:
https://doaj.org/article/eca5369f81bc4ad7bedd0952aee33ca6
Autor:
Ingrid van der Pluijm, George A Garinis, Renata M C Brandt, Theo G M F Gorgels, Susan W Wijnhoven, Karin E M Diderich, Jan de Wit, James R Mitchell, Conny van Oostrom, Rudolf Beems, Laura J Niedernhofer, Susana Velasco, Errol C Friedberg, Kiyoji Tanaka, Harry van Steeg, Jan H J Hoeijmakers, Gijsbertus T J van der Horst
Publikováno v:
PLoS Biology, Vol 5, Iss 1, p e2 (2007)
Cockayne syndrome (CS) is a photosensitive, DNA repair disorder associated with progeria that is caused by a defect in the transcription-coupled repair subpathway of nucleotide excision repair (NER). Here, complete inactivation of NER in Csb(m/m)/Xpa
Externí odkaz:
https://doaj.org/article/e01574a8f78b49088291bb604cfb7cb5
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Persistent DNA lesions build up with aging triggering inflammation, the body’s first line of immune defense strategy against foreign pathogens and irritants. Once established, DNA damage-driven inflammation takes on a momentum of its own, due to th
Externí odkaz:
https://doaj.org/article/32683dcba8ab4cf6bb434a98c214baef
Autor:
Arturo Bujarrabal-Dueso, Georg Sendtner, David H. Meyer, Georgia Chatzinikolaou, Kalliopi Stratigi, George A. Garinis, Björn Schumacher
Publikováno v:
Nature Structural & Molecular Biology. 30:475-488
The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has remained unknown whether not only lesion-type-specific, but overall repair capacities could be improved. Here we show that the DREAM repressor complex curbs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da356922b6d09b1f6e99497d36a8446c
https://doi.org/10.1038/s41594-023-00942-8
https://doi.org/10.1038/s41594-023-00942-8
Publikováno v:
Trends in Molecular Medicine. 27:907-922
Progeroid syndromes (PSs) are characterized by the premature onset of age-related pathologies. The genetic mutations underlying PSs are functionally linked to genome maintenance and repair, supporting the causative role of DNA damage accumulation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0378e4b488063f75968ad7022a9db901
https://doi.org/10.1016/j.molmed.2021.06.011
https://doi.org/10.1016/j.molmed.2021.06.011
Publikováno v:
BMC Bioinformatics. 23
Background In fluorescence microscopy, co-localization refers to the spatial overlap between different fluorescent labels in cells. The degree of overlap between two or more channels in a microscope may reveal a physical interaction or topological fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8f1e4c1b1ae53b348fd5f91c53dd99
https://doi.org/10.1186/s12859-022-04988-1
https://doi.org/10.1186/s12859-022-04988-1