High-level dietary cadmium exposure is associated with global DNA hypermethylation in the gastropod hepatopancreas.

Autor: Dragos V Nica, Cristina Popescu, George A Draghici, Florina-Maria Andrica, Ionela A Privistirescu, Iosif I Gergen, Reinhard Stöger

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184221 (2017)

5-methylcytosine (5mC) is a key epigenetic mark which influences gene expression and phenotype. In vertebrates, this epigenetic mark is sensitive to Cd exposure, but there is no information linking such an event with changes in global 5mC levels in t

Externí odkaz: https://doaj.org/article/9ca7bca872674d5c868b188cac46cebf

Space Maintainers Used in Pediatric Dentistry: An Insight of Their Biosecurity Profile by Applying In Vitro Methods

Autor: Magda Mihaela Luca, Malina Popa, Claudia G. Watz, Iulia Pinzaru, George Andrei Draghici, Ciprian V. Mihali, Cristina Adriana Dehelean, Roxana Buzatu, Camelia Szuhanek

Publikováno v: Materials, Vol 14, Iss 20, p 6215 (2021)

Space maintainers have presented an increased interest due to their chemical composition which influences the electrochemical and electrolytic processes of the oral cavity, leading to important biological activity. The present study was purported to

Externí odkaz: https://doaj.org/article/359bbd8a0a6c4c9699e3e16151355a38

Insights into the Behavior of Triple-Negative MDA-MB-231 Breast Carcinoma Cells Following the Treatment with 17β-Ethinylestradiol and Levonorgestrel

Autor: Sebastian Simu, Iasmina Marcovici, Amadeus Dobrescu, Daniel Malita, Cristina Adriana Dehelean, Dorina Coricovac, Flavius Olaru, George Andrei Draghici, Dan Navolan

Publikováno v: Molecules, Vol 26, Iss 9, p 2776 (2021)

Oral contraceptives (OCs) are widely used due to their efficiency in preventing unplanned pregnancies and treating several human illnesses. Despite their medical value, the toxicity of OCs remains a public concern. Previous studies indicate the carci

Externí odkaz: https://doaj.org/article/40823f41b64041a99be49756893527d2

Novel Synthesized N-Ethyl-Piperazinyl-Amides of C2-Substituted Oleanonic and Ursonic Acids Exhibit Cytotoxic Effects through Apoptotic Cell Death Regulation

Autor: Alexandra Mioc, Adrian Voicu, I. P. Baikova, C. Soica, Stefana Avram, Irina Smirnova, Marius Mioc, Lavinia Vlaia, Ioana Macașoi, Oxana B. Kazakova, George Andrei Draghici, Cristina Dehelean

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 10967, p 10967 (2021)
Volume 22
Issue 20

A series of novel hybrid chalcone N-ethyl-piperazinyl amide derivatives of oleanonic and ursonic acids were synthesized, and their cytotoxic potential was evaluated in vitro against the NCI-60 cancer cell line panel. Compounds 4 and 6 exhibited the h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdcd8de318b1e9d68a4d15a0487ec6c
http://europepmc.org/articles/PMC8536124

Impact of soil cadmium on land snails: a two-stage exposure approach under semi-field conditions using bioaccumulative and conchological end-points of exposure.

Autor: Dragos V Nica, Marioara Nicoleta Filimon, Despina-Maria Bordean, Monica Harmanescu, George Andrei Draghici, Simona Dragan, Iosif I Gergen

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0116397 (2015)

Land snails are highly tolerant to cadmium exposure and are able to accumulate soil cadmium independently of food ingestion. However, little information exists on the kinetics of cadmium retention in terrestrial gastropods exposed to an increase in t

Externí odkaz: https://doaj.org/article/7332928a6fb347e08cd00de511d72aed