Zobrazeno 1 - 10
of 208
pro vyhledávání: '"George A, Truskey"'
Autor:
Alastair Khodabukus, Neel K. Prabhu, Taylor Roberts, Meghan Buldo, Amber Detwiler, Zachary D. Fralish, Megan E. Kondash, George A. Truskey, Timothy R. Koves, Nenad Bursac
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract Dysferlin is a multi‐functional protein that regulates membrane resealing, calcium homeostasis, and lipid metabolism in skeletal muscle. Genetic loss of dysferlin results in limb girdle muscular dystrophy 2B/2R (LGMD2B/2R) and other dysfer
Externí odkaz:
https://doaj.org/article/6700577ad99f405e9fef15eac55bfc59
Autor:
Kevin L. Shores, George A. Truskey
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disorder that causes severe cardiovascular disease, resulting in the death of patients in their teenage years. The disease pathology is caused by the accumulation of progerin, a mutated
Externí odkaz:
https://doaj.org/article/346de8b83705421aa2998306b993de49
Autor:
Jounghyun H. Lee, Kevin L. Shores, Jason J. Breithaupt, Caleb S. Lee, Daniella M. Fodera, Jennifer B. Kwon, Adarsh R. Ettyreddy, Kristin M. Myers, Benny J. Evison, Alexandra K. Suchowerska, Charles A. Gersbach, Kam W. Leong, George A. Truskey
Publikováno v:
APL Bioengineering, Vol 7, Iss 4, Pp 046103-046103-15 (2023)
Atherosclerosis is a primary precursor of cardiovascular disease (CVD), the leading cause of death worldwide. While proprotein convertase subtilisin/kexin 9 (PCSK9) contributes to CVD by degrading low-density lipoprotein receptors (LDLR) and altering
Externí odkaz:
https://doaj.org/article/f6d0b5cc6b244d04bac23d3123f01c78
Autor:
Nadia O. Abutaleb, Leigh Atchison, Leandro Choi, Akhil Bedapudi, Kevin Shores, Yantenew Gete, Kan Cao, George A. Truskey
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, fatal genetic disease that accelerates atherosclerosis. With a limited pool of HGPS patients, clinical trials face unique challenges and require reliable preclinical testing. We previous
Externí odkaz:
https://doaj.org/article/795072a3654d418481cb34a30863502b
Autor:
Qiao Zhang, Ren‐Zhi Zhan, Marisa Patsy, Binjie Li, Yifan Chen, Barbara D. Lipes, Nenad Bursac, George A. Truskey
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/f2661d05231448598b09fc547fc38fbb
Autor:
Maria J. Torres, Xu Zhang, Dorothy H. Slentz, Timothy R. Koves, Hailee Patel, George A. Truskey, Deborah M. Muoio
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105189- (2022)
Summary: Two prominent frontline breast cancer (BC) chemotherapies commonly used in combination, doxorubicin (DOX) and docetaxel (TAX), are associated with long-lasting cardiometabolic and musculoskeletal side effects. Whereas DOX has been linked to
Externí odkaz:
https://doaj.org/article/c8925c5ae8554c5e8f3c1c0d1e770e8d
Autor:
George A. Truskey
Publikováno v:
Bioengineering, Vol 10, Iss 9, p 1066 (2023)
When combined with patient information provided by advanced imaging techniques, computational biomechanics can provide detailed patient-specific information about stresses and strains acting on tissues that can be useful in diagnosing and assessing t
Externí odkaz:
https://doaj.org/article/8aa9fd52b16a4d4799984fec1e04cdbc
Autor:
Christopher G Vann, Xin Zhang, Alastair Khodabukus, Melissa C. Orenduff, Yu-Hsiu Chen, David L. Corcoran, George A. Truskey, Nenad Bursac, Virginia B. Kraus
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Exercise affects the expression of microRNAs (miR/s) and muscle-derived extracellular vesicles (EVs). To evaluate sarcoplasmic and secreted miR expression in human skeletal muscle in response to exercise-mimetic contractile activity, we utilized a th
Externí odkaz:
https://doaj.org/article/01b3dc9dd88a468698e95c74c8051b9e
Autor:
Muath Bishawi, Franklin H. Lee, Dennis M. Abraham, Carolyn Glass, Stephanie J. Blocker, Daniel J. Cox, Zachary D. Brown, Howard A. Rockman, Lan Mao, Tony C. Slaba, Mark W. Dewhirst, George A. Truskey, Dawn E. Bowles
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104086- (2022)
Summary: The complex and inaccessible space radiation environment poses an unresolved risk to astronaut cardiovascular health during long-term space exploration missions. To model this risk, healthy male c57BL/6 mice aged six months (corresponding to
Externí odkaz:
https://doaj.org/article/43a2ac87251e41e4a3c21bafd33ba469
Autor:
Xu Zhang, Muath Bishawi, Ge Zhang, Varun Prasad, Ellen Salmon, Jason J. Breithaupt, Qiao Zhang, George A. Truskey
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Human microphysiological systems (MPS) have some advantages over animal models to study the mechanisms of disease. Here the authors use a tissue-engineered blood vessel MPS to create a model of early stage atherosclerosis and assess the effect of sev
Externí odkaz:
https://doaj.org/article/8d57cac5f23b4a1ca7ed71c83c025052