Zobrazeno 1 - 10
of 284
pro vyhledávání: '"George A, Kuchel"'
Autor:
Ben Kirk, Chia‐Ling Kuo, Peiran Liu, Meiruo Xiang, Jacob E. Earp, Jatupol Kositsawat, George A. Kuchel, Gustavo Duque
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 3, Pp 1157-1166 (2024)
Abstract Background Telomere attrition may share common biological mechanisms with bone and muscle loss with aging. Here, we investigated the association between these hallmarks of aging using data from UK Biobank, a large observational study. Method
Externí odkaz:
https://doaj.org/article/a8abbe64191943fb8c04ae9e17d6a44f
Autor:
Dominique E. Martin, Andreia N. Cadar, Hunter Panier, Blake L. Torrance, George A. Kuchel, Jenna M. Bartley
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Aging is associated with progressive declines in immune responses leading to increased risk of severe infection and diminished vaccination responses. Influenza (flu) is a leading killer of older adults despite availability of seas
Externí odkaz:
https://doaj.org/article/174196bb8f364bd0ae00e27a3165f380
Autor:
Chris P. Verschoor, Daniel W. Belsky, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, Janet E. McElhaney, George A. Kuchel
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Background Biological aging represents a loss of integrity and functionality of physiological systems over time. While associated with an enhanced risk of adverse outcomes such as hospitalization, disability and death following infection, it
Externí odkaz:
https://doaj.org/article/b31517b3e7594943be5d302e6a7cabc9
Autor:
Emilie Picard, Sarah Armstrong, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, George A. Kuchel, Janet E. McElhaney, Chris P. Verschoor
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background With increasing age, overall health declines while systemic levels of inflammatory mediators tend to increase. Although the underlying mechanisms are poorly understood, there is a wealth of data suggesting that this so-called “i
Externí odkaz:
https://doaj.org/article/7ebbef19822844c38fada3f9ca189613
Autor:
Chris P. Verschoor, Emilie Picard, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, George A. Kuchel
Publikováno v:
Frontiers in Aging, Vol 3 (2023)
Granzymes are a family of serine-proteases that act as critical mediators in the cytolytic and immunomodulatory activities of immune cells such as CD8+ T-cells and natural killer (NK) cells. Previous work indicates that both granzyme B (GZB) and K (G
Externí odkaz:
https://doaj.org/article/01483b3e1f824e2f8aff87686c52a556
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 3, Pp 344-349 (2022)
Background and Aims: Fatty infiltration of the pancreas has been shown to be associated with both precancerous pancreatic lesions and pancreatic ductal adenocarcinoma. We aim to determine predictors of fatty infiltration of the pancreas in United Sta
Externí odkaz:
https://doaj.org/article/6e83c1d73a464c9ea1ed2711b5fc9950
Autor:
Xin Zhou, Baohong Wang, Patrick C. Demkowicz, Jethro S. Johnson, Yanfei Chen, Daniel J. Spakowicz, Yanjiao Zhou, Yair Dorsett, Lei Chen, Erica Sodergren, George A. Kuchel, George M. Weinstock
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Growing evidence has linked an altered host fecal microbiome composition with health status, common chronic diseases, and institutionalization in vulnerable older adults. However, fewer studies have described microbiome changes in healthy older adult
Externí odkaz:
https://doaj.org/article/c92ee11682d3496aaa13091b78272114
Autor:
Asa Thibodeau, Alper Eroglu, Christopher S. McGinnis, Nathan Lawlor, Djamel Nehar-Belaid, Romy Kursawe, Radu Marches, Daniel N. Conrad, George A. Kuchel, Zev J. Gartner, Jacques Banchereau, Michael L. Stitzel, A. Ercument Cicek, Duygu Ucar
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Detecting multiplets in single nucleus (sn)ATAC-seq data is challenging due to data sparsity and limited dynamic range. AMULET (ATAC-seq MULtiplet Estimation Tool) enumerates regions with greater than two uniquely aligned reads across the ge
Externí odkaz:
https://doaj.org/article/16ab6a3786b04036bf43b168af964002
Publikováno v:
Nutrients, Vol 15, Iss 12, p 2679 (2023)
The endocannabinoid system (ECS) participates in regulating whole body energy balance. Overactivation of the ECS has been associated with the negative consequence of obesity and type 2 diabetes. Since activators of the ECS rely on lipid-derived ligan
Externí odkaz:
https://doaj.org/article/6ee6514b1dc64f63ae36bdea68aef636
Autor:
Manish Kumar, Shivaraj Patil, Lucas Da Cunha Godoy, Chia-Ling Kuo, Helen Swede, George A. Kuchel, Kai Chen
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
IntroductionThe impact of demand ischemia on clinical outcomes in patients with delirium remains largely unexplored. This study aims to evaluate the effects of demand ischemia in older patients with delirium on in-hospital mortality and length of sta
Externí odkaz:
https://doaj.org/article/af2d77c3a4a745c984a28f7379ec301d