Zobrazeno 1 - 10
of 13
pro vyhledávání: '"George Doellgast"'
Autor:
Eileen Johnson, Jerry Ryan Holder, Barton H. Manning, Licheng Shi, Kevin Salyers, Michael Stenkilsson, Colin V. Gegg, Marie E. Wright, George Doellgast, Kenneth D. Wild, Les P. Miranda
Publikováno v:
Biopolymers. 100:422-430
Antagonism of the calcitonin gene-related peptide (CGRP) receptor may be a useful approach for migraine treatment. Selective PEGylated peptide antagonists to the CGRP receptor are described, derived from CGRP(8-37) with polymer derivatization at an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ea37007135bf79af7cc0c5558bc94bf
https://doi.org/10.1002/bip.22270
https://doi.org/10.1002/bip.22270
Autor:
Adrian Moore, Yongming Gao, Chris Paszty, Fay Vlasseros, Jianhua Gong, Barbara Tipton, Daniel John Lightwood, Alistair James Henry, Jacquelin Jolette, M. D. Hale, Jin Cao, Susan Y. Smith, Michael S. Ominsky, W. Scott Simonet, George Doellgast, David L. Lacey, Jill Cai, Brian Stouch, Rohini Deshpande, Andrew George Popplewell, Lei Zhou, Martyn K. Robinson, Kevin Graham
Publikováno v:
Journal of Bone and Mineral Research. 25:948-959
The development of bone-rebuilding anabolic agents for treating bone-related conditions has been a long-standing goal. Genetic studies in humans and mice have shown that the secreted protein sclerostin is a key negative regulator of bone formation. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccf634b38a4df943e84067917a54246
https://doi.org/10.1002/jbmr.14
https://doi.org/10.1002/jbmr.14
Autor:
Deanna Mohn, George Doellgast, Kameswara Rao V. Kuchimanchi, Tom Horan, Gerald Siu, Mark E. Dalphin, Frederick W. Jacobsen, Michelle Horner, Helen Kim, Wenyan D. Shen, Daniela Metz, Liana Zhang, Rohini Deshpande, Ming Zhang, James B. Chung, Adimoolam Narayanan
Publikováno v:
European Journal of Pharmacology. 610:110-118
The ICOS (Inducible T cell Co-Stimulator)/B7RP-1 (B7-related protein 1) interaction is critical for the proper activation of a T lymphocyte. In this manuscript we describe a systematic in vivo approach to determine the level of blockade required to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1211ea9af5416b36a6220acaed38d62d
https://doi.org/10.1016/j.ejphar.2009.03.023
https://doi.org/10.1016/j.ejphar.2009.03.023
Autor:
Fergus R. Byrne, Aaron Winters, David Brankow, Sylvia Hu, Todd Juan, Shirley Steavenson, George Doellgast, Kamesh Kuchimanchi, Heather Brown, Sharon Anderson, Sara Smelt, Tim Sullivan, Dina Alcorn, Joel Tocker, Charley Dean, John Macmaster, Jacqueline Kirchner, Janet Buys, Raffi Manoukian, Eric Jiao, Xiaoming Zou, Gabriele S. Campanella, Gerald Siu
Publikováno v:
Autoimmunity. 42:171-182
IP-10 secretion is induced by pro-inflammatory cytokines and mediates the migration of CXCR3+ cells. Its elevation in clinical samples has been associated with multiple inflammatory diseases and its antagonism has been reported to be effective in sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bb11d9e9915a2f393e6d3f20007095
https://doi.org/10.1080/08916930802629547
https://doi.org/10.1080/08916930802629547
Autor:
Licheng Shi, Jennifer Aral, Richard S. Rogers, Violeta G. Valladares, Hongyan Li, Marie E. Wright, Kevin Salyers, Eileen Johnson, Jerry Ryan Holder, Les P. Miranda, Kenneth W. Walker, George Doellgast, Colin V. Gegg, Kenneth D. Wild, Brian D. Bennett
Publikováno v:
Journal of Medicinal Chemistry. 51:7889-7897
Calcitonin gene-related peptide (CGRP) is a 37-residue neuropeptide that can be converted to a CGRP(1) receptor antagonist by the truncation of its first seven residues. CGRP(8-37), 1, has a CGRP(1) receptor K(i) = 3.2 nM but is rapidly degraded in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6e67e4b147d3e6c1d74e860256269e
https://doi.org/10.1021/jm8009298
https://doi.org/10.1021/jm8009298
Autor:
Les P, Miranda, Licheng, Shi, Jerry R, Holder, Marie, Wright, Colin V, Gegg, Eileen, Johnson, Kenneth, Wild, Michael, Stenkilsson, George, Doellgast, Barton H, Manning, Kevin, Salyers
Publikováno v:
Biopolymers. 100(4)
Antagonism of the calcitonin gene-related peptide (CGRP) receptor may be a useful approach for migraine treatment. Selective PEGylated peptide antagonists to the CGRP receptor are described, derived from CGRP(8-37) with polymer derivatization at an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a31b70dedf454786a35ff7d2eadd6074
https://pubmed.ncbi.nlm.nih.gov/23868210
https://pubmed.ncbi.nlm.nih.gov/23868210
Publikováno v:
Blood cells, moleculesdiseases. 45(3)
Anemia in cancer patients can result from a complex interaction of numerous factors including iron deficiency, inflammation, toxicity related to therapy and effect of cancer on the marrow. Determining effective anemia treatment can therefore be compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8879b8f545c2cf421160b017ff39e72a
https://pubmed.ncbi.nlm.nih.gov/20800515
https://pubmed.ncbi.nlm.nih.gov/20800515
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 51(5)
Measurement of the total target ligand can help to provide pharmacokinetic (PK) and pharmacodynamic (PD) informations. However, the presence of monocloncal antibody therapeutics (ThAs) interferes with ELISA determinations of the total target proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87e263b3b38eb74ba7b50fdb5d07891
https://pubmed.ncbi.nlm.nih.gov/20022440
https://pubmed.ncbi.nlm.nih.gov/20022440
Publikováno v:
The journal of investigative dermatology. Symposium proceedings. 12(1)
Immunologic limitations make it difficult to study the pharmacokinetic effects of human tumor necrosis factor (TNF) blockers in murine models. To counter this, we have studied the pharmacokinetics in mice of two murine analogs of human TNF blockers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ad51a8a9039fe1aca0654353a859e3
https://pubmed.ncbi.nlm.nih.gov/17502872
https://pubmed.ncbi.nlm.nih.gov/17502872
Autor:
George Doellgast
The objective of this Phase I effort, was to develop an amplified immunoassay which could detect botulinal neurotoxins A, B, E and F at concentrations equivalent to the mouse toxicity assay (i.e. 5 pg/ml). Reasons for doing this included the likeliho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3977d818004dc17ce8efafde8741729e
https://doi.org/10.21236/adb164360
https://doi.org/10.21236/adb164360
