Perioperative complications and oncological outcomes of post-chemotherapy retroperitoneal lymph node dissection in patients with germ cell cancer at two high-volume university centres in Switzerland – a retrospective chart review

Autor: Marco Notarfrancesco, Christian D. Fankhauser, Anja Lorch, Davide Ardizzone, Simon Helnwein, Dennis Hoch, Thomas Hermanns, George Thalmann, Jörg Beyer

Publikováno v: Swiss Medical Weekly, Vol 153, Iss 4 (2023)

BACKGROUND: Post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) is an integral part of the management of patients with metastatic non-seminoma and residual masses >1 cm after chemotherapy. AIMS: To assess perioperative complications

Externí odkaz: https://doaj.org/article/54bb01449a7c40feb5fcb11c8694d9e2

Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression

Autor: Marco Bolis, Daniela Bossi, Arianna Vallerga, Valentina Ceserani, Manuela Cavalli, Daniela Impellizzieri, Laura Di Rito, Eugenio Zoni, Simone Mosole, Angela Rita Elia, Andrea Rinaldi, Ricardo Pereira Mestre, Eugenia D’Antonio, Matteo Ferrari, Flavio Stoffel, Fernando Jermini, Silke Gillessen, Lukas Bubendorf, Peter Schraml, Arianna Calcinotto, Eva Corey, Holger Moch, Martin Spahn, George Thalmann, Marianna Kruithof-de Julio, Mark A. Rubin, Jean-Philippe P. Theurillat

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Transcriptional changes during prostate cancer progression are not yet fully understood. Here, the authors integrate a transcriptomics atlas of prostate cancer and validate it with preclinical models and single-cell RNA-seq, revealing the role of EZH

Externí odkaz: https://doaj.org/article/6a080edb8c7340f18674ce8c5a8eaff3

Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors

Autor: Alessandro Alaimo, Marco Lorenzoni, Paolo Ambrosino, Arianna Bertossi, Alessandra Bisio, Alice Macchia, Eugenio Zoni, Sacha Genovesi, Francesco Cambuli, Veronica Foletto, Dario De Felice, Maria Virginia Soldovieri, Ilaria Mosca, Francesco Gandolfi, Matteo Brunelli, Gianluca Petris, Anna Cereseto, Alvaro Villarroel, George Thalmann, Francesco Giuseppe Carbone, Marianna Kruithof-de Julio, Mattia Barbareschi, Alessandro Romanel, Maurizio Taglialatela, Andrea Lunardi

Publikováno v: Cell Death and Disease, Vol 11, Iss 12, Pp 1-17 (2020)

Abstract Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer

Externí odkaz: https://doaj.org/article/df6bf34ea7084a21b91211d2e2dccd09

Data from DNA Methylation Landscapes of Prostate Cancer Brain Metastasis Are Shaped by Early Driver Genetic Alterations

Autor: Salvatore Piscuoglio, Mark A. Rubin, Charlotte K.Y. Ng, Silke Gillessen, Felix Y. Feng, George Thalmann, Holger Moch, Lukas Bubendorf, Adeboye O. Osunkoya, Gieri Cathomas, Wolfram Jochum, Ingeborg Fischer, Rainer Grobholz, Elisabeth J. Rushing, Achim Fleischmann, Vera Genitsch, Ekkehard Hewer, Ursula Amstutz, Sina Maletti, Dilara Akhoundova, Andrej Benjak, Antonio Rodriguez-Calero, John Gallon

Metastases from primary prostate cancers to rare locations, such as the brain, are becoming more common due to longer life expectancy resulting from improved treatments. Epigenetic dysregulation is a feature of primary prostate cancer, and distinct D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c01e91a2e85cb1dd840d1e92384f00
https://doi.org/10.1158/0008-5472.c.6599642.v1

DNA methylation landscapes of prostate cancer brain metastasis are shaped by early driver genetic alterations

Autor: John Gallon, Antonio Rodriguez-Calero, Andrej Benjak, Dilara Akhoundova, Sina Maletti, Ursula Amstutz, Ekkehard Hewer, Vera Genitsch, Achim Fleischmann, Elisabeth J. Rushing, Rainer Grobholz, Ingeborg Fischer, Wolfram Jochum, Gieri Cathomas, Adeboye O. Osunkoya, Lukas Bubendorf, Holger Moch, George Thalmann, Felix Y. Feng, Silke Gillessen, Charlotte K.Y. Ng, Mark A. Rubin, Salvatore Piscuoglio

Publikováno v: Gallon, John; Rodríguez-Calero, Antonio; Benjak, Andrej; Akhoundova, Dilara; Maletti, Sina; Amstutz, Ursula; Hewer, Ekkehard; Genitsch, Vera; Fleischmann, Achim; Rushing, Elisabeth J; Grobholz, Rainer; Fischer, Ingeborg; Jochum, Wolfram; Cathomas, Gieri; Osunkoya, Adeboye O; Bubendorf, Lukas; Moch, Holger; Thalmann, George; Feng, Felix Y; Gillessen, Silke; ... (2023). DNA methylation landscapes of prostate cancer brain metastasis are shaped by early driver genetic alterations. Cancer research, 83(8), pp. 1203-1213. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-22-2236
Cancer research, vol. 83, no. 8, pp. 1203-1213

Metastases from primary prostate cancers to rare locations, such as the brain, are becoming more common due to longer life expectancy resulting from improved treatments. Epigenetic dysregulation is a feature of primary prostate cancer, and distinct D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce9031aefed757cc227ffba65be48c1
https://boris.unibe.ch/178505/1/can-22-2236.pdf