Zobrazeno 1 - 10
of 407
pro vyhledávání: '"George, Somlo"'
Autor:
Jeffrey Y.C. Wong, An Liu, Chunhui Han, Savita Dandapani, Timothy Schultheiss, Joycelynne Palmer, Dongyun Yang, George Somlo, Amandeep Salhotra, Susanta Hui, Monzr M. Al Malki, Joseph Rosenthal, Anthony Stein
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
PurposeTMI utilizes IMRT to deliver organ sparing targeted radiotherapy in patients undergoing hematopoietic cell transplantation (HCT). TMI addresses an unmet need, specifically patients with refractory or relapsed (R/R) hematologic malignancies who
Externí odkaz:
https://doaj.org/article/781b27c5914643079ce0c1807c94ff4e
Autor:
Colt A. Egelston, Weihua Guo, Susan E. Yost, Xuan Ge, Jin Sun Lee, Paul H. Frankel, Yujie Cui, Christopher Ruel, Daniel Schmolze, Mireya Murga, Aileen Tang, Norma Martinez, Misagh Karimi, George Somlo, Peter Lee, James Waisman, Yuan Yuan
Publikováno v:
Cancer Research. 83:OT2-08
Background: Combination of immune checkpoint inhibitor pembrolizumab and chemotherapy are standard of care therapy for patients with programmed death-ligand 1 positive (PD-L1+) metastatic triple negative breast cancer (mTNBC). However, a greater unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::544d072e62f00b294a13384ba8ab9cdc
https://doi.org/10.1158/1538-7445.sabcs22-ot2-08-03
https://doi.org/10.1158/1538-7445.sabcs22-ot2-08-03
Autor:
Hitomi Mori, Kohei Saeki, Gregory Chang, Jinhui Wang, Xiwei Wu, Noriko Kanaya, George Somlo, Shiuan Chen
Publikováno v:
Cancer Research. 83:P3-11
Background: While estrogen typically promotes the progression of hormone-dependent breast cancer via the activation of estrogen receptor (ER)-α, estrogen-induced suppression of ER+ breast cancer has been clinically observed. Our previous study demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cab3333fb0678cd35c46bf3dbe2c5e14
https://doi.org/10.1158/1538-7445.sabcs22-p3-11-05
https://doi.org/10.1158/1538-7445.sabcs22-p3-11-05
Autor:
Bihong T. Chen, Sean K. Sethi, Taihao Jin, Sunita K. Patel, Ningrong Ye, Can-Lan Sun, Russell C. Rockne, E. Mark Haacke, James C. Root, Andrew J. Saykin, Tim A. Ahles, Andrei I. Holodny, Neal Prakash, Joanne Mortimer, James Waisman, Yuan Yuan, George Somlo, Daneng Li, Richard Yang, Heidi Tan, Vani Katheria, Rachel Morrison, Arti Hurria
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-11 (2018)
Abstract Background Cognitive decline is among the most feared treatment-related outcomes of older adults with cancer. The majority of older patients with breast cancer self-report cognitive problems during and after chemotherapy. Prior neuroimaging
Externí odkaz:
https://doaj.org/article/f97028d3e0274e60a6cee5856b614605
Autor:
Sayeh M. Lavasani, George Somlo, Susan E. Yost, Paul H. Frankel, Christopher Ruel, Yujie Cui, Mireya Murga, Aileen Tang, Norma Martinez, Laura Kruper, Lusine Tumyan, Daniel Schmolze, Christina Yeon, Yuan Yuan, James R. Waisman, Joanne Mortimer
Publikováno v:
Cancer. 129:740-749
The objective of this study was to evaluate the safety and efficacy of nab-paclitaxel, trastuzumab, and pertuzumab as neoadjuvant therapy (NAT) in patients with human epidermal growth factor receptor 2 HER2+ breast cancer (HER2+ BC) to determine path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cf80e5c152c33037dc84e544cb2d61
https://doi.org/10.1002/cncr.34589
https://doi.org/10.1002/cncr.34589
Autor:
Shaheen S. Sikandar, Angera H. Kuo, Tomer Kalisky, Shang Cai, Maider Zabala, Robert W. Hsieh, Neethan A. Lobo, Ferenc A. Scheeren, Sopheak Sim, Dalong Qian, Frederick M. Dirbas, George Somlo, Stephen R. Quake, Michael F. Clarke
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tu
Externí odkaz:
https://doaj.org/article/f0f50f3b3e2d42029e585ebb81c7168c
Autor:
Yuan Yuan, Nilesh Vora, Can-Lan Sun, Daneng Li, Enrique Soto-Perez-de-Celis, Joanne Mortimer, The-hang Luu, George Somlo, James Waisman, David Smith, Joseph Chao, Vani Katheria, Timothy Synold, Vivi Tran, Shu Mi, Abrahm Levi, Anait Arsenyan, Jennifer Choi, Laura Zavala, Susan Yost, Arti Hurria
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-10 (2017)
Abstract Background Chemotherapy decreases the risk of relapse and mortality in early-stage breast cancer (BC), but it comes with the risk of toxicity. Chemotherapy efficacy depends on relative dose intensity (RDI), and an RDI
Externí odkaz:
https://doaj.org/article/5c139d33dc20478394479753585657cf
Autor:
Paola A. Betancur, Brian J. Abraham, Ying Y. Yiu, Stephen B. Willingham, Farnaz Khameneh, Mark Zarnegar, Angera H. Kuo, Kelly McKenna, Yoko Kojima, Nicholas J. Leeper, Po Ho, Phung Gip, Tomek Swigut, Richard I. Sherwood, Michael F. Clarke, George Somlo, Richard A. Young, Irving L. Weissman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Super-enhancers (SEs) are big DNA regions regulating the transcription of oncogenes. Here the authors identify two SE regions regulating the expression of CD47, a protein expressed by cancer cells to avoid phagocytosis by macrophages, thus suggesting
Externí odkaz:
https://doaj.org/article/78521d1c01db4a828a254b9785273b10
Autor:
Shizhen Emily Wang, Jeremy M. Stark, David K. Ann, Timothy R. O'Connor, Sean Timothy Francis O'Connor, Yang Xu, Yang Yu, Hui Li, Andrew R. Chin, Miranda Y. Fong, George Somlo, Xiubao Ren, Chun-Ting Cheng, Weiying Zhou, Liang Liu
Figure S1. Effect of TGFβ in BT474 and MCF7 BC cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2a453d6734a5dedafef6df68b4659e
https://doi.org/10.1158/1541-7786.22511544.v1
https://doi.org/10.1158/1541-7786.22511544.v1
Autor:
Shizhen Emily Wang, Jeremy M. Stark, David K. Ann, Timothy R. O'Connor, Sean Timothy Francis O'Connor, Yang Xu, Yang Yu, Hui Li, Andrew R. Chin, Miranda Y. Fong, George Somlo, Xiubao Ren, Chun-Ting Cheng, Weiying Zhou, Liang Liu
Transforming growth factor beta (TGFβ) proteins are multitasking cytokines, in which high levels at tumor sites generally correlate with poor prognosis in human patients with cancer. Previously, it was reported that TGFβ downregulates the expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc35296b2e0df6cee806d78a22823a65
https://doi.org/10.1158/1541-7786.c.6539970.v1
https://doi.org/10.1158/1541-7786.c.6539970.v1