Zobrazeno 1 - 10
of 106
pro vyhledávání: '"George, Simos"'
Autor:
Kreon Koukoulas, Antonis Giakountis, Angeliki Karagiota, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3468-3489 (2021)
The hypoxia‐inducible factor HIF‐1 is essential for oxygen homeostasis. Despite its well‐understood oxygen‐dependent expression, regulation of its transcriptional activity remains unclear. We show that phosphorylation by extracellular signal
Externí odkaz:
https://doaj.org/article/96b5fdc018014ecb9f0b7ff7a70f7dfc
Autor:
Chrysa Taze, Sotiria Drakouli, Martina Samiotaki, George Panayotou, George Simos, Eleni Georgatsou, Ilias Mylonis
Publikováno v:
Redox Biology, Vol 58, Iss , Pp 102545- (2022)
The cellular response to hypoxia, in addition to HIF-dependent transcriptional reprogramming, also involves less characterized transcription-independent processes, such as alternative splicing of the VEGFA transcript leading to the production of the
Externí odkaz:
https://doaj.org/article/c2aac6436ca34230b1d797e213c692b8
Autor:
Angelos Yfantis, Ilias Mylonis, Georgia Chachami, Marios Nikolaidis, Grigorios D. Amoutzias, Efrosyni Paraskeva, George Simos
Publikováno v:
Cells, Vol 12, Iss 5, p 798 (2023)
The Hypoxia Inducible Factor 1 (HIF-1) plays a major role in the cellular response to hypoxia by regulating the expression of many genes involved in adaptive processes that allow cell survival under low oxygen conditions. Adaptation to the hypoxic tu
Externí odkaz:
https://doaj.org/article/6ab1181c8ed842868f85a0a7a71d80e0
Autor:
Kreon Koukoulas, Vasiliki Lygoura, Philip Kartalidis, Nikolaos K. Gatselis, Efthymia Petinaki, George N. Dalekos, George Simos
Publikováno v:
Diagnostics, Vol 12, Iss 6, p 1404 (2022)
Hepcidin regulates iron metabolism by inhibiting intestinal iron absorption and iron release from iron stores. In addition to iron overload, inflammatory conditions also up-regulate hepcidin synthesis, which may serve as an antimicrobial defense by r
Externí odkaz:
https://doaj.org/article/c0bde628847b42d3b9fcd9fc36e1d3d9
Autor:
Antonis E. Koromilas, George Simos, Kostas Pantopoulos, Leda Raptis, Suiyang Li, Hala Muaddi, Philippos Peidis, Efrosyni Paraskeva, Andreas I. Papadakis
Hypoxia within the tumor microenvironment promotes angiogenesis, metabolic reprogramming, and tumor progression. In addition to activating hypoxia-inducible factor-1α (HIF-1α), cells also respond to hypoxia by globally inhibiting protein synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57156bbabc712aa29041c821dad319b9
https://doi.org/10.1158/0008-5472.c.6501158.v1
https://doi.org/10.1158/0008-5472.c.6501158.v1
Autor:
Antonis E. Koromilas, George Simos, Kostas Pantopoulos, Leda Raptis, Suiyang Li, Hala Muaddi, Philippos Peidis, Efrosyni Paraskeva, Andreas I. Papadakis
Supplementary Figures 1-6 from eIF2α Kinase PKR Modulates the Hypoxic Response by Stat3-Dependent Transcriptional Suppression of HIF-1α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47573ca9101fac0210e6bb2ea7403d9
https://doi.org/10.1158/0008-5472.22385231
https://doi.org/10.1158/0008-5472.22385231
Publikováno v:
The FEBS Journal.
Publikováno v:
Cells, Vol 9, Iss 11, p 2359 (2020)
Sumoylation is the covalent attachment of the small ubiquitin-related modifier (SUMO) to a vast variety of proteins in order to modulate their function. Sumoylation has emerged as an important modification with a regulatory role in the cellular respo
Externí odkaz:
https://doaj.org/article/c4521f209043449bbd4de439d9022000
Autor:
George Panayotou, Antonis Giakountis, Kreon Koukoulas, Angeliki Karagiota, Ilias Mylonis, George Simos, Martina Samiotaki
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 15, Iss 12, Pp 3468-3489 (2021)
Molecular Oncology, Vol 15, Iss 12, Pp 3468-3489 (2021)
The hypoxia‐inducible factor HIF‐1 is essential for oxygen homeostasis. Despite its well‐understood oxygen‐dependent expression, regulation of its transcriptional activity remains unclear. We show that phosphorylation by extracellular signal