Zobrazeno 1 - 8
of 8
pro vyhledávání: '"George, Punkosdy"'
Autor:
Eric Haines, Michael Burke, Rachel Catterall, Victor De Jesus, Bin Li, Joseph D. Manna, George Punkosdy, Oksana Zavidij, Sarah R. Wessel, Grace Werosta, Jill Cavanaugh, Sheila Newhouse, Aravind Basavapathruni, Lan Xu, Sergio Santillana, X. Michelle Zhang, Sabine K. Ruppel
Publikováno v:
Molecular Cancer Research. 21:PR10-PR10
Alterations in the RAS/RAF/MEK/ERK pathway are the most common drivers of oncogenesis. Although MEK is a clinically validated cancer target and several MEK inhibitors have been approved by the FDA, their clinical utility is limited to BRAFV600 mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28f2462c249dd35c7b1ef3c0266b05ea
https://doi.org/10.1158/1557-3125.ras23-pr10
https://doi.org/10.1158/1557-3125.ras23-pr10
Autor:
Nathan Young, George Punkosdy, Jill Cavanaugh, Collin Bantle, Alex Constan, Bin Li, James Conley, Marta Sanchez-Martin, Lan Xu, Karen McGovern, Alfredo Castro, Michelle Zhang, Jeffrey Ecsedy
Publikováno v:
Cancer Research. 83:1646-1646
The Hippo signaling cascade regulates cell proliferation and survival, as well as overall tissue homeostasis. These functions are mediated by the TEAD family of transcription factors which, when bound to the co-activators YAP or TAZ, induce expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0326ec2bbe9360f6bc660d9041ad7bda
https://doi.org/10.1158/1538-7445.am2023-1646
https://doi.org/10.1158/1538-7445.am2023-1646
Autor:
Souheil-Antoine Younes, George Punkosdy, Stephane Caucheteux, Tao Chen, Zvi Grossman, William E Paul
Publikováno v:
PLoS Biology, Vol 9, Iss 10, p e1001171 (2011)
Memory phenotype (CD44(bright), CD25(negative)) CD4 spleen and lymph node T cells (MP cells) proliferate rapidly in normal or germ-free donors, with BrdU uptake rates of 6% to 10% per day and Ki-67 positivity of 18% to 35%. The rapid proliferation of
Externí odkaz:
https://doaj.org/article/15ccd62a1e97471dae43545209843a23
Autor:
Frank O, Richards, Josef, Amann, Byron, Arana, George, Punkosdy, Robert, Klein, Carlos, Blanco, Beatriz, Lopez, Carlos, Mendoza, Alfredo, Domínguez, Jeannette, Guarner, James H, Maguire, Mark, Eberhard
Publikováno v:
The American journal of tropical medicine and hygiene. 77(5)
Endosymbionic Wolbachia bacteria inside adult Onchocerca volvulus worms (causing river blindness) are necessary for female worm fertility. We evaluated whether rifampin and/or azithromycin used in a five-day course could kill Wolbachia. In an open-la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4014369f5942e0f5625df5b592f4cc3f
https://pubmed.ncbi.nlm.nih.gov/17984346
https://pubmed.ncbi.nlm.nih.gov/17984346
Autor:
Kevin L, Winthrop, Roberto, Proaño, Orlando, Oliva, Byron, Arana, Carlos, Mendoza, Alfredo, Dominguez, Josef, Amann, George, Punkosdy, Carlos, Blanco, Robert, Klein, Mauricio, Sauerbrey, Frank, Richards
Publikováno v:
The American journal of tropical medicine and hygiene. 75(6)
World Health Organization certification criteria for onchocerciasis elimination use anterior segment eye lesion prevalence as an indicator of mass ivermectin treatment program success. Lesions either contain visible microfilaria (noninflammatory punc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13a426c0bcf61d0f23f490899a045650
https://pubmed.ncbi.nlm.nih.gov/17172365
https://pubmed.ncbi.nlm.nih.gov/17172365
Autor:
George Punkosdy, Ethan Shevach
Publikováno v:
The Journal of Immunology. 190:50.32-50.32
While Treg exhibit an anergic phenotype in vitro, Treg proliferate in vivo at a rate similar to memory phenotype (MP; defined as CD44hi, CD62Llo) CD4+ T cells. In short-term BrdU labeling experiments, both populations uptake the label at a rate of 6%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::612359e7811d8e7e6694dae72ee0933a
https://doi.org/10.4049/jimmunol.190.supp.50.32
https://doi.org/10.4049/jimmunol.190.supp.50.32
Autor:
Michael Holt, George Punkosdy, Melissa Blain, Deborah Glass, Mary Lozano, Jaquelin Dudley, Ethan Shevach
Publikováno v:
The Journal of Immunology. 188:111.26-111.26
Mounting evidence has demonstrated the presence of a population of thymic CD8+ T cells that share phenotypic and functional similarity to “innate-like” or “memory-like” T cells. Innate CD8+ T cells have increased expression of CD44, CD122, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98143ddf2c582cd2228911087246a860
https://doi.org/10.4049/jimmunol.188.supp.111.26
https://doi.org/10.4049/jimmunol.188.supp.111.26
Autor:
George Punkosdy, Ethan Shevach
Publikováno v:
The Journal of Immunology. 186:168.22-168.22
Regulatory T cells (Treg) maintain immune homeostasis by preventing excessive immune activation. This is clear in neonates since mice lacking Treg (scurfy) develop multi-organ autoimmunity early in life. However, the mechanism by which Treg maintain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e370707aad59432754f94c2b344330c5
https://doi.org/10.4049/jimmunol.186.supp.168.22
https://doi.org/10.4049/jimmunol.186.supp.168.22