Zobrazeno 1 - 10
of 1 331
pro vyhledávání: '"George, Perry"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionNeurobiological changes in the hippocampus are a common consequence of aging. However, there are differences in the rate of decline and overall volume loss in people with no cognitive impairment compared to those with mild cognitive impai
Externí odkaz:
https://doaj.org/article/320e5fab348443f495da28fecadc93b7
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/2758d4954af8408ca2fce3eb0f829a97
Autor:
Wenzhang Wang, Fanpeng Zhao, Yubing Lu, Sandra L. Siedlak, Hisashi Fujioka, Hao Feng, George Perry, Xiongwei Zhu
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Loss of synapses is the most robust pathological correlate of Alzheimer’s disease (AD)-associated cognitive deficits, although the underlying mechanism remains incompletely understood. Synaptic terminals have abundant mitochondria which pl
Externí odkaz:
https://doaj.org/article/82f66d1de547420abc67f18f0345be0f
Autor:
Ana M. Diaz-Lasprilla, Meagan McKee, Andrea C. Jimenez-Vergara, Swathisri Ravi, Devon Bellamy, Wendy Ortega, Cody O. Crosby, Jennifer Steele, Germán Plascencia-Villa, George Perry, Dany J. Munoz-Pinto
Publikováno v:
Gels, Vol 10, Iss 3, p 203 (2024)
Multicomponent interpenetrating polymer network (mIPN) hydrogels are promising tissue-engineering scaffolds that could closely resemble key characteristics of native tissues. The mechanical and biochemical properties of mIPNs can be finely controlled
Externí odkaz:
https://doaj.org/article/d0bbe3ebb5da4c2584499bc4afc27940
Autor:
Gilberto Ruiz-De-La-Cruz, Ana María Sifuentes-Rincón, Francisco Alejandro Paredes-Sánchez, Gaspar Manuel Parra-Bracamonte, Eduardo Casas, Thomas H. Welsh Jr., David Greg Riley, George Perry, Ronald D. Randel
Publikováno v:
Revista Brasileira de Zootecnia, Vol 52 (2023)
ABSTRACT The objective of this study was to evaluate the effect of intronic single nucleotide polymorphisms (SNP) on temperament traits in a Brahman cattle population. The SNP located in CACNG4, EXOC4, NRXN3, and SLC9A4 candidate genes were genotyped
Externí odkaz:
https://doaj.org/article/864a968af7ce432391e2e9a2ccf15e57
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-14 (2022)
Abstract Alzheimer’s disease (AD), a critical neurodegenerative condition, has a wide range of effects on brain activity. Synaptic plasticity and neuronal circuits are the most vulnerable in Alzheimer’s disease, but the exact mechanism is unknown
Externí odkaz:
https://doaj.org/article/bcdd13a378f24e65a1b49a976ba22dda
Autor:
Parnian Shobeiri, Sanam Alilou, Mehran Jaberinezhad, Farshad Zare, Nastaran Karimi, Saba Maleki, Antonio L. Teixeira, George Perry, Nima Rezaei
Publikováno v:
PLoS ONE, Vol 18, Iss 3 (2023)
Background Long non-coding RNAs (lncRNAs) have been reported to be involved in the pathogenesis of neurodegenerative diseases. It has also been hypothesized that plasma exosomal lncRNAs may be used as Alzheimer’s disease (AD) biomarkers. In this sy
Externí odkaz:
https://doaj.org/article/5b9476986a9d479b8d86445e0fcc6298
Autor:
Kang-Lin Hsieh, German Plascencia-Villa, Ko-Hong Lin, George Perry, Xiaoqian Jiang, Yejin Kim
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105678- (2023)
Summary: Developing drugs for treating Alzheimer’s disease has been extremely challenging and costly due to limited knowledge of underlying mechanisms and therapeutic targets. To address the challenge in AD drug development, we developed a multi-ta
Externí odkaz:
https://doaj.org/article/ebd6ce2e589b4922a4ef151f6d63d9d5
Recent advances in Medicinal Chemistry is a book series focused on leading-edge research on developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural
Autor:
QuanQiu Wang, Pamela B. Davis, Xin Qi, Shu G. Chen, Mark E. Gurney, George Perry, P. Murali Doraiswamy, Rong Xu
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background Interactions between the gut microbiota, microglia, and aging may modulate Alzheimer’s disease (AD) pathogenesis but the precise nature of such interactions is not known. Methods We developed an integrated multi-dimensional, kno
Externí odkaz:
https://doaj.org/article/8e709b3481924b4487ab57ec171a616d