Zobrazeno 1 - 10
of 15
pro vyhledávání: '"George, Painter"'
Autor:
Sébastien Bihorel, Youfang Cao, Akshita Chawla, Ruthie Birger, Brian M. Maas, Wei Gao, Stefan Roepcke, Susanne Sardella, Rebecca Humphrey, Sindhuri Kondragunta, Bhuvana Jayaraman, Monika Martinho, Wendy Painter, George Painter, Wayne Holman, Carisa De Anda, Michelle L. Brown, Matthew G. Johnson, Amanda Paschke, Matthew L. Rizk, Julie A. Stone
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 1859-1871 (2023)
Abstract Effective antiviral treatments for coronavirus disease 2019 (COVID‐19) are needed to reduce the morbidity and mortality associated with severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) infection, particularly in patients
Externí odkaz:
https://doaj.org/article/8cddadd8bcca434f80fe87480a247f8a
Autor:
Wendy Holman, Wayne Holman, Stacy McIntosh, Wendy Painter, George Painter, Jim Bush, Oren Cohen
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-7 (2021)
Abstract A recently published article described the safety, tolerability, and pharmacokinetic profile of molnupiravir (Painter et al. 2021), a novel antiviral agent with potent activity against severe acute respiratory syndrome coronavirus 2 (SARS-Co
Externí odkaz:
https://doaj.org/article/d1e53963604f46b1972249643a11a389
Autor:
Scott Foster, Randall Lanier, Alice Robertson, Richard W. Moyer, George Painter, Bernhard Lampert, Brandi R. Manning, Stacey A. Gray, Daniele Swetnam, Andrew J. Smith, Mathew M. Adams, Greg Wallace, Scott F. Lindsey, Andrew M. Burrage, Amanda D. Rice
Publikováno v:
Viruses, Vol 3, Iss 1, Pp 47-62 (2011)
CMX001, a lipophilic nucleotide analog formed by covalently linking 3-(hexdecyloxy)propan-1-ol to cidofovir (CDV), is being developed as a treatment for smallpox. In the absence of human cases of smallpox, new treatments must be tested for efficacy i
Externí odkaz:
https://doaj.org/article/bf0ed56610444bce8a4cd6d67495c2a4
Autor:
Richard W. Moyer, George Painter, Randall Lanier, Amanda D. Rice, Scott Foster, Bernhard Lampert, Mathew M. Adams, Alice Robertson
Publikováno v:
Viruses, Vol 3, Iss 2, Pp 63-82 (2011)
CMX001, a lipophilic nucleotide analog formed by covalently linking 3‑(hexdecyloxy)propan-1-ol to cidofovir (CDV), is being developed as a treatment for smallpox. CMX001 has dramatically increased potency versus CDV against all dsDNA viruses and, i
Externí odkaz:
https://doaj.org/article/5abde05a4aab44b9a015981bb33c74d5
Autor:
George Painter, Merrick Almond, Rose O’Mahony, Wendy Painter, Michelle Rose, Scott Foster, Alice Robertson, Bernhard Lampert, Tim Tippin, Lawrence Trost, Randall Lanier
Publikováno v:
Viruses, Vol 2, Iss 12, Pp 2740-2762 (2010)
CMX001 (phosphonic acid, [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]mono[3-(hexadecyloxy)propyl] ester) is a lipid conjugate of the acyclic nucleotide phosphonate, cidofovir (CDV). CMX001 is currently in Phase II clinica
Externí odkaz:
https://doaj.org/article/8bb528dacb8942f9af22a56489437ab8
Publikováno v:
Viruses, Vol 2, Iss 9, Pp 1918-1932 (2010)
The absence of herd immunity to orthopoxviruses and the concern that variola or monkeypox viruses could be used for bioterroristic activities has stimulated the development of therapeutics and safer prophylactics. One major limitation in this process
Externí odkaz:
https://doaj.org/article/08c1c16d5f5d4d2b967be153cfba6450
Autor:
Oren Cohen, Wendy Holman, Wayne Holman, Wendy Painter, Stacy McIntosh, George Painter, Jim Bush
A recently published article described the safety, tolerability and pharmacokinetic profile of molnupiravir, a novel antiviral agent with potent activity against SARS-CoV-2, the causative agent of COVID-19. Here, we report an unprecedented collaborat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fc40362b03eb6f794da2430076d60d5
https://doi.org/10.21203/rs.3.rs-477300/v1
https://doi.org/10.21203/rs.3.rs-477300/v1
Autor:
George, Painter
Publikováno v:
Science (New York, N.Y.). 354(6316)
Autor:
Scott, Parker, Jill, Schriewer, Christina, Oberle, Alice, Robertson, Randall, Lanier, George, Painter, R Mark, Buller
Publikováno v:
Antiviral Therapy. 13:863-873
Background The emergence of human monkeypox and the potential use of recombinant variola and monkey-pox viruses as biological terrorist agents have necessitated the development of therapeutic and prophylactic therapies. The primary, or index, cases o
Autor:
Berton C. Pressman, George Painter
Publikováno v:
Biochemical and Biophysical Research Communications. 97:1268-1275
Summary Circular dichroism (CD) was utilized to probe two discrete loci of the ionophore lasalocid A during conformational perturbations associated with complex formation. This required deconvolution of the observed CD spectrum into components arisin