The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional mapping

Autor: Benjamin S. Beresford-Jones, Samuel C. Forster, Mark D. Stares, George Notley, Elisa Viciani, Hilary P. Browne, Daniel J. Boehmler, Amelia T. Soderholm, Nitin Kumar, Kevin Vervier, Justin R. Cross, Alexandre Almeida, Trevor D. Lawley, Virginia A. Pedicord

Publikováno v: Cell Host & Microbe

Summary Human health and disease have increasingly been shown to be impacted by the gut microbiota, and mouse models are essential for investigating these effects. However, the compositions of human and mouse gut microbiotas are distinct, limiting tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b788fd70c50baa6c4e252ed917bbba16

Functional and taxonomic comparison of mouse and human gut microbiotas using extensive culturing and metagenomics

Autor: Virginia A. Pedicord, Trevor D. Lawley, Stares, Elisa Viciani, Samuel C. Forster, Beresford-Jones Bs, Nitin Kumar, Hilary P. Browne, Kevin Vervier, Alexandre Almeida, George Notley

Mouse models are essential for biomedical science and drug discovery, yet it is not known how the bacteria in the mouse microbiota – important determinants of phenotypes of health and disease –affect their relevance to human disease. To interroga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29b60cd1a49c381bf9a1a2736043e0af
https://doi.org/10.1101/2021.02.11.430759

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

Autor: Maria A. Duque Correa, Simon P. Forman, Anneliese O. Speak, Dmitry S. Ushakov, Natasha A. Karp, Susana Caetano, Heather M. Wilson, George X. Song-Zhao, Matthew Edmans, Jacqueline K. White, Adam Laing, Namita Saran, Kevin J. Maloy, Justin Meskas, Sibyl Drissler, Emma L. Cambridge, Anna Chan, William R. Jacobs, Jua Iwasaki, Eleanor Cawthorne, Ramiro Ramirez-Solis, Alice Yue, Markus Pasztorek, Tanya L. Crockford, Richard K. Grencis, Amrutha Meeniga, Adrian Hayday, Cordelia Brandt, Albina Rahim, Terrence F. Meehan, Markus Lux, Leanne Kane, Belén Morón, George Notley, Johannes Abeler, Natasha Strevens, Keng I. Hng, Mark Griffiths, Carmen Ballesteros Reviriego, Katherine Harcourt, Fiona Powrie, Richard J. Cornall, David Melvin, Jeremy Mason, Jonathan Warren, David J. Adams, Simon Clare, Katherine R. Bull, Ryan R. Brinkman, Anna Lorenc, Gillian M. Griffiths, K. O. Babalola, Gordon Dougan, Brian Weinrick, Clare M. Lloyd, Lucie Abeler-Dörner, Philippa R. Barton, Agnieszka Przemska-Kosicka

Publikováno v: Forman, S, Grencis, R & et al. 2019, ' High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation ', Nature Immunology, vol. 21, pp. 86-100 . https://doi.org/10.1038/s41590-019-0549-0
Nat Immunol

By developing a high-density murine immunophenotyping platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation. Specifically, high-throughput phenotyping of 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2af8846d8b60da029e9a0d672bfa60

Sa612 MULTI-FUNCTIONAL LIVE BACTERIAL THERAPEUTIC FOR ULCERATIVE COLITIS DERIVED FROM PRECISION METAGENOMIC ANALYSIS OF CLINICAL FMT STUDY

Autor: Seánín M. McCluskey, Catherine Stevenson, Oliver Rimington, Isobel Whitehead, Trevor D. Lawley, Ghaith Bakdash, Adam Wilkinson, Fernanda Schreiber, Marta Vergara-Irigaray, Simon R. Harris, Dominika Klisko, Matthew Duke, Thomas Mitchell, George Notley, Jacob W. Muckle, Matthew R. Robinson, Anne Six, Anne Neville, Amy Popple

Publikováno v: Gastroenterology. 160:S-573

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c4a06d6f4ca23927b58dbafb0cf72b2
https://doi.org/10.1016/s0016-5085(21)02068-0