Stacked mutations in wheat homologues of rice SEMI-DWARF1 confer a novel semi-dwarf phenotype

Autor: Barbora Ndreca, Alison Huttly, Sajida Bibi, Carlos Bayon, George Lund, Joshua Ham, Rocío Alarcón-Reverte, John Addy, Danuše Tarkowská, Stephen Pearce, Peter Hedden, Stephen G. Thomas, Andrew L. Phillips

Publikováno v: BMC Plant Biology, Vol 24, Iss 1, Pp 1-15 (2024)

Abstract Background Semi-dwarfing alleles are used widely in cereals to confer improved lodging resistance and assimilate partitioning. The most widely deployed semi-dwarfing alleles in rice and barley encode the gibberellin (GA)-biosynthetic enzyme

Externí odkaz: https://doaj.org/article/d49aad68e6d34f639e77ec1521d14a32

Land Management Legacy Affects Abundance and Function of the acdS Gene in Wheat Root Associated Pseudomonads

Autor: Heather L. Ruscoe, Rodrigo G. Taketani, Ian M. Clark, George Lund, David Hughes, Ian C. Dodd, Penny R. Hirsch, Tim H. Mauchline

Publikováno v: Frontiers in Microbiology, Vol 12 (2021)

Land management practices can vastly influence belowground plant traits due to chemical, physical, and biological alteration of soil properties. Beneficial Pseudomonas spp. are agriculturally relevant bacteria with a plethora of plant growth promotin

Externí odkaz: https://doaj.org/article/b8c24772854242a5842518f12a7347da

MIBiG 3.0:: a community-driven effort to annotate experimentally validated biosynthetic gene clusters

Autor: Barbara R Terlouw, Kai Blin, Jorge C Navarro-Muñoz, Nicole E Avalon, Marc G Chevrette, Susan Egbert, Sanghoon Lee, David Meijer, Michael J J Recchia, Zachary L Reitz, Jeffrey A van Santen, Nelly Selem-Mojica, Thomas Tørring, Liana Zaroubi, Mohammad Alanjary, Gajender Aleti, César Aguilar, Suhad A A Al-Salihi, Hannah E Augustijn, J Abraham Avelar-Rivas, Luis A Avitia-Domínguez, Francisco Barona-Gómez, Jordan Bernaldo-Agüero, Vincent A Bielinski, Friederike Biermann, Thomas J Booth, Victor J Carrion Bravo, Raquel Castelo-Branco, Fernanda O Chagas, Pablo Cruz-Morales, Chao Du, Katherine R Duncan, Athina Gavriilidou, Damien Gayrard, Karina Gutiérrez-García, Kristina Haslinger, Eric J N Helfrich, Justin J J van der Hooft, Afif P Jati, Edward Kalkreuter, Nikolaos Kalyvas, Kyo Bin Kang, Satria Kautsar, Wonyong Kim, Aditya M Kunjapur, Yong-Xin Li, Geng-Min Lin, Catarina Loureiro, Joris J R Louwen, Nico L L Louwen, George Lund, Jonathan Parra, Benjamin Philmus, Bita Pourmohsenin, Lotte J U Pronk, Adriana Rego, Devasahayam Arokia Balaya Rex, Serina Robinson, L Rodrigo Rosas-Becerra, Eve T Roxborough, Michelle A Schorn, Darren J Scobie, Kumar Saurabh Singh, Nika Sokolova, Xiaoyu Tang, Daniel Udwary, Aruna Vigneshwari, Kristiina Vind, Sophie P J M Vromans, Valentin Waschulin, Sam E Williams, Jaclyn M Winter, Thomas E Witte, Huali Xie, Dong Yang, Jingwei Yu, Mitja Zdouc, Zheng Zhong, Jérôme Collemare, Roger G Linington, Tilmann Weber, Marnix H Medema

Publikováno v: Nucleic Acids Research, 51(D1), D603-D610. Oxford University Press
Terlouw, B R, Blin, K, Navarro-Muñoz, J C, Avalon, N E, Chevrette, M G, Egbert, S, Lee, S, Meijer, D, Recchia, M J J, Reitz, ZL, van Santen, JA, Selem-Mojica, N, Tørring, T, Zaroubi, L, Alanjary, M, Aleti, G, Aguilar, C, Al-Salihi, S A A, Augustijn, HE, Avelar-Rivas, JA, Avitia-Domínguez, LA, Barona-Gómez, F, Bernaldo-Agüero, J, Bielinski, V A, Biermann, F, Booth, TJ, Carrion Bravo, VJ, Castelo-Branco, R, Chagas, FO, Cruz-Morales, P, Du, C, Duncan, KR, Gavriilidou, A, Gayrard, D, Gutiérrez-García, K, Haslinger, K, Helfrich, E J N, van der Hooft, J J J, Jati, AP, Kalkreuter, E, Kalyvas, N, Kang, KB, Kautsar, S, Kim, W, Kunjapur, AM, Li, Y-X, Lin, G-M, Loureiro, C, Louwen, J J R, Louwen, N L L, Lund, G, Parra, J, Philmus, B, Pourmohsenin, B, Pronk, L J U, Rego, A, Rex, DAB, Robinson, S, Rosas-Becerra, LR, Roxborough, ET, Schorn, MA, Scobie, DJ, Singh, KS, Sokolova, N, Tang, X, Udwary, D, Vigneshwari, A, Vind, K, Vromans, S P J M, Waschulin, V, Williams, SE, Winter, JM, Witte, TE, Xie, H, Yang, D, Yu, J, Zdouc, M, Zhong, Z, Collemare, J, Linington, RG, Weber, T & Medema, MH 2023, ' MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters ', Nucleic Acids Research, vol. 51, no. D1, gkac1049, pp. D603-D610 . https://doi.org/10.1093/nar/gkac1049
Terlouw, B R, Blin, K, Navarro-Muñoz, J C, Avalon, N E, Chevrette, M G, Egbert, S, Lee, S, Meijer, D, Recchia, M J J, Reitz, Z L, van Santen, J A, Selem-Mojica, N, Tørring, T, Zaroubi, L, Alanjary, M, Aleti, G, Aguilar, C, Al-Salihi, S A A, Augustijn, H E, Avelar-Rivas, J A, Avitia-Domínguez, L A, Barona-Gómez, F, Bernaldo-Agüero, J, Bielinski, V A, Biermann, F, Booth, T J, Carrion Bravo, V J, Castelo-Branco, R, Chagas, F O, Cruz-Morales, P, Du, C, Duncan, K R, Gavriilidou, A, Gayrard, D, Gutiérrez-García, K, Haslinger, K, Helfrich, E J N, van der Hooft, J J J, Jati, A P, Kalkreuter, E, Kalyvas, N, Kang, K B, Kautsar, S, Kim, W, Kunjapur, A M, Li, Y-X, Lin, G-M, Loureiro, C, Louwen, J J R, Louwen, N L L, Lund, G, Parra, J, Philmus, B, Pourmohsenin, B, Pronk, L J U, Rego, A, Rex, D A B, Robinson, S, Rosas-Becerra, L R, Roxborough, E T, Schorn, M A, Scobie, D J, Singh, K S, Sokolova, N, Tang, X, Udwary, D, Vigneshwari, A, Vind, K, Vromans, S P J M, Waschulin, V, Williams, S E, Winter, J M, Witte, T E, Xie, H, Yang, D, Yu, J, Zdouc, M, Zhong, Z, Collemare, J, Linington, R G, Weber, T & Medema, M H 2023, ' MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters ', Nucleic Acids Research, vol. 51, no. D1, pp. D603–D610 . https://doi.org/10.1093/nar/gkac1049
Terlouw, B R, Blin, K, Navarro-Muñoz, J C, Avalon, N E, Chevrette, M G, Egbert, S, Lee, S, Meijer, D, Recchia, M J J, Reitz, Z L, van Santen, J A, Selem-Mojica, N, Tørring, T, Zaroubi, L, Alanjary, M, Aleti, G, Aguilar, C, Al-Salihi, S A A, Augustijn, H E, Avelar-Rivas, J A, Avitia-Domínguez, L A, Barona-Gómez, F, Bernaldo-Agüero, J, Bielinski, V A, Biermann, F, Booth, T J, Carrion Bravo, V J, Castelo-Branco, R, Chagas, F O, Cruz-Morales, P, Du, C, Duncan, K R, Gavriilidou, A, Gayrard, D, Gutiérrez-García, K, Haslinger, K, Helfrich, E J N, van der Hooft, J J J, Jati, A P, Kalkreuter, E, Kalyvas, N, Kang, K B, Kautsar, S, Kim, W, Kunjapur, A M, Li, Y-X, Lin, G-M, Loureiro, C, Louwen, J J R, Louwen, N L L, Lund, G, Parra, J, Philmus, B, Pourmohsenin, B, Pronk, L J U, Rego, A, Rex, D A B, Robinson, S, Rosas-Becerra, L R, Roxborough, E T, Schorn, M A, Scobie, D J, Singh, K S, Sokolova, N, Tang, X, Udwary, D, Vigneshwari, A, Vind, K, Vromans, S P J M, Waschulin, V, Williams, S E, Winter, J M, Witte, T E, Xie, H, Yang, D, Yu, J, Zdouc, M, Zhong, Z, Collemare, J, Linington, R G, Weber, T & Medema, M H 2023, ' MIBiG 3.0 : a community-driven effort to annotate experimentally validated biosynthetic gene clusters ', Nucleic Acids Research, vol. 51, no. D1, pp. D603–D610 . https://doi.org/10.1093/nar/gkac1049
Nucleic acids research, 51(D1), D603-D610
Nucleic acids research 51 (2023) D1

With an ever-increasing amount of (meta)genomic data being deposited in sequence databases, (meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs, crop protection agents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e557bd5c3d2ddd7d6574fc9d08027c2
https://pure.knaw.nl/portal/en/publications/4e99309a-6840-4150-801f-070cfa20d40c

Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain

Autor: Shirish, Shukla, Weijiang, Ying, Felicia, Gray, Yiwu, Yao, Miranda L, Simes, Qingjie, Zhao, Hongzhi, Miao, Hyo Je, Cho, Paula, González-Alonso, Alyssa, Winkler, George, Lund, Trupta, Purohit, EunGi, Kim, Xiaotian, Zhang, Joshua M, Ray, Shihan, He, Caroline, Nikolaidis, Juliano, Ndoj, Jingya, Wang, Łukasz, Jaremko, Mariusz, Jaremko, Russell J H, Ryan, Monica L, Guzman, Jolanta, Grembecka, Tomasz, Cierpicki

Publikováno v: Nature chemical biology. 17(7)

Polycomb repressive complex 1 (PRC1) is an essential chromatin-modifying complex that monoubiquitinates histone H2A and is involved in maintaining the repressed chromatin state. Emerging evidence suggests PRC1 activity in various cancers, rationalizi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a253d998755f3560046fc8e6a7b49a1
https://pubmed.ncbi.nlm.nih.gov/34155403

Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein–Ligand Complexes

Autor: Trupta Purohit, George Lund, Tomasz Cierpicki, Dmitry Borkin, Jonathan Pollock, Jolanta Grembecka, Edyta Dyguda-Kazimierowicz

Publikováno v: Journal of Medicinal Chemistry

Multipolar interactions involving fluorine and the protein backbone have been frequently observed in protein-ligand complexes. Such fluorine-backbone interactions may substantially contribute to the high affinity of small molecule inhibitors. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1edaa4ace380db1050e40a07594366b
http://europepmc.org/articles/PMC4584387