Zobrazeno 1 - 10 of 244 pro vyhledávání: '"George, Just"'
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Akademický článek
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis
Autor: Alastair J. Hayes, Xiaozhong Zheng, James O’Kelly, Lucile P.A. Neyton, Natalia A. Bochkina, Iain Uings, John Liddle, J. Kenneth Baillie, George Just, Margaret Binnie, Natalie Z.M. Homer, Toby B.J. Murray, James Baily, Kris McGuire, Christos Skouras, O. James Garden, Scott P. Webster, John P. Iredale, Sarah E.M. Howie, Damian J. Mole
Publikováno v: Cell Reports, Vol 42, Iss 8, Pp 112763- (2023)
Summary: Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now. Here, we show that the KMO product 3-hydrox
Externí odkaz: https://doaj.org/article/60fcd40d031a4ce4a162a97e4de568a3
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The depth of anaesthesia associated with the administration of isoflurane 2.5% during cardiopulmonary bypass
Autor: Natalie Z.M. Homer, C.J. MacKenzie, Michael Connelly, R. Peter Alston, George Just
Publikováno v: Perfusion. 34:392-398
Background:Administering isoflurane 2.5% into the oxygenator during cardiopulmonary bypass results in no patient movement. However, doing so may result in an excessive depth of anaesthesia particularly, when hypothermia is induced. Bispectral index a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfa0b833e2e7aaffe0e7266cf84d55a
https://doi.org/10.1177/0267659118822946
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3
Automated Supported Liquid Extraction for the analysis of a panel of 12 endogenous steroids in human plasma by LC-MS/MS
Autor: Robert M. Gifford, George Just, Patricia Lee, Joanna Simpson, Rebecca M. Reynolds, Scott Denham, Jennifer Richardson, Ruth Andrew, Catriona Kyle, Natalie Z.M. Homer
Steroid analysis is important in the clinical assessment of endocrine function in health and disease. Although tandem mass spectrometry methods coupled with chromatographic separation are considered the gold standard analytical technique in this sett
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a384ff1133a418160dfbebbf40b851
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4
Coronary Sinus Isoflurane Concentration in Cardiac Surgery
Autor: C. McKenzie, George Just, Ka Ting Ng, R. Peter Alston
Publikováno v: Journal of Cardiothoracic and Vascular Anesthesia. 31:2035-2041
Objective Volatile anesthetic agents such as isoflurane may be associated with fewer adverse myocardial events compared with total intravenous anesthesia in cardiac surgery. The authors aimed to determine whether reasonable isoflurane concentrations
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2563696648a353cc7d1eec4e1610c3
https://doi.org/10.1053/j.jvca.2017.03.014
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Assessing the depth of isoflurane anaesthesia during cardiopulmonary bypass
Autor: C. McKenzie, Ka Ting Ng, George Just, R. Peter Alston
Publikováno v: Perfusion. 33:148-155
Introduction: Bispectral index (BIS) and monitoring of end-tidal concentration may be associated with a reduction in the incidence of awareness during volatile-based general anaesthesia. An analogue of end-tidal concentration during cardiopulmonary b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204a31abda9e63439f4b2ea8643f6f91
https://doi.org/10.1177/0267659117735883
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6
Quantitative analysis of 11-dehydrocorticosterone and corticosterone for preclinical studies by liquid chromatography triple quadrupole mass spectrometry
Autor: Karen E. Chapman, Mark Nixon, Manu Verma, Karen Sooy, Natalie Z.M. Homer, Ruth Morgan, George Just, Ruth Andrew
Publikováno v: Verma, M, Sooy, K, Just, G, Nixon, M, Morgan, R, Andrew, R, Chapman, K & Homer, N 2019, ' Quantitative analysis of 11-dehydrocorticosterone and corticosterone for preclinical studies by liquid chromatography triple quadrupole mass spectrometry ', Rapid communications in mass spectrometry . https://doi.org/10.1002/rcm.8610
Rapid Communications in Mass Spectrometry
Rationale The activity of the glucocorticoid activating enzyme 11β-hydroxysteroid dehydrogenase type-1 (11βHSD1) is altered in diseases such as obesity, inflammation and psychiatric disorders. In rodents 11βHSD1 converts inert 11-dehydrocorticoste
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1601a4f78284b33574363fc769359be
https://hdl.handle.net/20.500.11820/284ffa6d-8d03-4e28-80d3-9874351b4433
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7
Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart
Autor: Karen E. Chapman, Carmel M. Moran, Adrian Garcia-Burgos, Paula J. Brunton, Natalie Z.M. Homer, Emma J Agnew, Hermes Manos, Karen Sooy, Adrian Thomson, George Just, Rachel V. Richardson, Gillian A. Gray
Publikováno v: The Journal of Endocrinology
Agnew, E, Garcia-Burgos, A, Richardson, R, Manos, H, Thomson, A, Sooy, K, Just, G, Homer, N, Moran, C, Brunton, P J, Gray, G A & Chapman, K 2019, ' Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart ', Journal of Endocrinology . https://doi.org/10.1530/JOE-18-0666
Endogenous glucocorticoid action is important in the structural and functional maturation of the fetal heart. In fetal mice, although glucocorticoid concentrations are extremely low before E14.5, glucocorticoid receptor (GR) is expressed in the heart
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c890b5872d50a603eaac5943113c1f6f
https://pubmed.ncbi.nlm.nih.gov/31013474
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8
The Methyl Donor S-Adenosylmethionine Inhibits Active Demethylation of DNA
Autor: Moshe Szyf, J. David Knox, Nancy Detich, George Just, Stefan Hamm
Publikováno v: Journal of Biological Chemistry. 278:20812-20820
S-Adenosylmethionine (AdoMet) is the methyl donor of numerous methylation reactions. The current model is that an increased concentration of AdoMet stimulates DNA methyltransferase reactions, triggering hypermethylation and protecting the genome agai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3fc146a726a5ef6c0de2bf9cd3ed70d
https://doi.org/10.1074/jbc.m211813200
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9
Stereoselective synthesis of dithymidine phosphorothioates using d -xylose derived chiral auxiliaries
Autor: George Just, Yixin Lu
Publikováno v: Tetrahedron. 57:1677-1687
Different sized catalysts 1, 2, 5 and 7 were prepared and used as the activators in the coupling reactions of phosphoramidites with nucleosides. d -Xylose derived chiral auxiliary 22a has been synthesized and applied for the stereoselective synthesis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24bc1afabdbeff2a3755d52325a271a8
https://doi.org/10.1016/s0040-4020(00)01170-4
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