Zobrazeno 1 - 10
of 76
pro vyhledávání: '"George, Flouret"'
Publikováno v:
International Journal of Peptide and Protein Research. 38:169-175
We synthesized 10 analogs (1-10) derived from the sequence of [Pmp1,D-Trp2,Arg8]oxytocin, (parent antagonist or PA), (Pmp = beta,beta-pentamethylene-beta-mercaptopropionic acid) which is a potent antagonist (pA2 = 7.77) of the uterotonic effect of ox
Publikováno v:
Journal of Peptide Science. 12:412-419
Eleven new analogues were synthesized by modification of the potent oxytocin antagonist (OTA) [(S)Pmp(1), D-Trp(2), Pen(6), Arg(8)]-Oxytocin, or PA (parent antagonist), in which (S)Pmp = beta,beta-(3-thiapentamethylene)-beta-mercapto-propionic acid.
Publikováno v:
Journal of Peptide Science. 9:393-401
Twelve analogues were synthesized, their structure derived from modifications of [(S)Pmp1, D-Trp2, Pen6, Arg8]oxytocin, PA, in which (S)Pmp = β,β-(3-thiapentamethylene-β-mercaptopropionic acid). PA is a potent antagonist of the uterotonic effect o
Publikováno v:
Gynecologic and Obstetric Investigation. 56:213-217
The purpose of the present study was to develop a radioreceptor assay to monitor the pharmacokinetics of the oxytocin antagonist, TT-235, in the blood of the pregnant rat and baboon. The receptors used for this assay were prepared from the pregnant r
Autor:
Lajos Balaspiri, Kevin Mahan, Laird Wilson, Olivier Chaloin, George Flouret, T. Majewski, William M Brieher, Jirina Slaninova
Publikováno v:
Journal of Peptide Science. 8:314-326
Twenty analogues were synthesized of [Pmp1, D-Trp2, Arg8]oxytocin, PA, (Pmp = beta,beta-pentamethylene-beta-mercaptopropionic acid), a potent antagonist of the uterotonic effect of oxytocin in the rat (uterotonic test in vitro, pA2 = 7.77) and in the
Publikováno v:
Gynecological Endocrinology. 16:173-178
TT-235 is a potent oxytocin (OT) antagonist that blocks the action of OT at the receptor level. Previous studies have shown that pregnant baboons demonstrate nocturnal uterine contractions induced by OT as they near delivery. The purpose of this stud
Publikováno v:
Journal of the Society for Gynecologic Investigation. 5:251-254
OBJECTIVE: To ascertain the relative activity of five oxytocin antagonists (OTAs) in vivo in a tethered pregnant baboon model and compare these results to previously reported affinities in human and rat oxytocin receptor assays and median effective d