Zobrazeno 1 - 10
of 645
pro vyhledávání: '"George, Coukos"'
Autor:
Devanjali Dutta, L. Francisco Lorenzo-Martín, François Rivest, Nicolas Broguiere, Lucie Tillard, Simone Ragusa, Nathalie Brandenberg, Sylke Höhnel, Damien Saugy, Sylvie Rusakiewicz, Krisztian Homicsko, George Coukos, Matthias P. Lutolf
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-7 (2024)
Abstract Immunotherapy has emerged as a new standard of care for certain cancer patients with specific cellular and molecular makeups. However, there is still an unmet need for ex vivo models able to readily assess the effectiveness of immunotherapeu
Externí odkaz:
https://doaj.org/article/500b8010d8694a5e80a921b03b5440e1
Autor:
Yen‐Cheng Liu, Saeid Ansaryan, Jiayi Tan, Nicolas Broguiere, Luis Francisco Lorenzo‐Martín, Krisztian Homicsko, George Coukos, Matthias P. Lütolf, Hatice Altug
Publikováno v:
Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract Organoid tumor models have emerged as a powerful tool in the fields of biology and medicine as such 3D structures grown from tumor cells recapitulate better tumor characteristics, making these tumoroids unique for personalized cancer researc
Externí odkaz:
https://doaj.org/article/7f3287aaf2f046a1b562b7eb9bc79781
Autor:
Nils Graber, Nina Canova, Denise Bryant‐Lukosius, Glenn Robert, Blanca Navarro‐Rodrigo, Lionel Trueb, George Coukos, Manuela Eicher, Tourane Corbière, Sara Colomer‐Lahiguera
Publikováno v:
Health Expectations, Vol 27, Iss 4, Pp n/a-n/a (2024)
Abstract Background Experience‐Based Co‐Design (EBCD) is a multi‐stage participatory action research process which was developed originally to increase patient involvement in service improvement initiatives. This viewpoint article serves as a r
Externí odkaz:
https://doaj.org/article/e5a2fa5990d74831bfb54e5f43fc3ac0
Autor:
Julien Schmidt, Johanna Chiffelle, Marta A. S. Perez, Morgane Magnin, Sara Bobisse, Marion Arnaud, Raphael Genolet, Julien Cesbron, David Barras, Blanca Navarro Rodrigo, Fabrizio Benedetti, Alexandra Michel, Lise Queiroz, Petra Baumgaertner, Philippe Guillaume, Michael Hebeisen, Olivier Michielin, Tu Nguyen-Ngoc, Florian Huber, Melita Irving, Stéphanie Tissot-Renaud, Brian J. Stevenson, Sylvie Rusakiewicz, Denarda Dangaj Laniti, Michal Bassani-Sternberg, Nathalie Rufer, David Gfeller, Lana E. Kandalaft, Daniel E. Speiser, Vincent Zoete, George Coukos, Alexandre Harari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The success of cancer immunotherapy depends in part on the strength of antigen recognition by T cells. Here, we characterize the T cell receptor (TCR) functional (antigen sensitivity) and structural (monomeric pMHC-TCR off-rates) avidities o
Externí odkaz:
https://doaj.org/article/07eeb33e654749ddb84ed54edf7d260f
Autor:
Sandro Anchisi, Anita Wolfer, Bettina Bisig, Edoardo Missiglia, Amine Tiab, Ehab Mohamed Kamel, Olivier Michielin, George Coukos, Krisztian Homicsko
Publikováno v:
Cancer Biology & Therapy, Vol 24, Iss 1 (2023)
The treatment of BRAFV600E mutant melanoma has been revolutionized by BRAF inhibitors. Furthermore, the BRAF/MEK combination has shown further improvement in clinical outcomes in advanced and in adjuvant melanoma patients. In low-grade ovarian tumors
Externí odkaz:
https://doaj.org/article/3a81ea454bf54dd6b4cd935fc04e1029
Autor:
George Coukos, Denis Migliorini, Helen Carrasco Hope, Jana de Sostoa, Pierpaolo Ginefra, Yi-Hsuan Chiang, Cristina Jimenez Luna, Jesús Corria Osorio, Nicola Vannini
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/d29c7a86c27646b684926a5246e95264
Autor:
George Coukos, Helen Carrasco Hope, Pierpaolo Ginefra, Yi-Hsuan Chiang, Nicola Vannini, Sophie Nutten, Stephanie Blum Sperisen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/07eb85d5346a4211a882b73b81d470e7
Autor:
Ute F. Röhrig, Somi Reddy Majjigapu, Pierre Vogel, Aline Reynaud, Florence Pojer, Nahzli Dilek, Patrick Reichenbach, Kelly Ascenção, Melita Irving, George Coukos, Olivier Michielin, Vincent Zoete
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1773-1811 (2022)
The haem enzyme indoleamine 2,3-dioxygenase 1 (IDO1) catalyses the rate-limiting step in the kynurenine pathway of tryptophan metabolism and plays an essential role in immunity, neuronal function, and ageing. Expression of IDO1 in cancer cells result
Externí odkaz:
https://doaj.org/article/cf28d46a56e84bc6b249d5272612f6f4
Autor:
Efthymia-Iliana Matthaiou, Yi Guo, Jaleh Barar, Raphael Sandaltzopoulos, Lana E. Kandalaft, Chunsheng Li, George Coukos, Yadollah Omidi
Publikováno v:
BioImpacts, Vol 12, Iss 1, Pp 65-86 (2022)
Introduction: Tumor endothelial marker 1 (TEM1) is expressed by tumor vascular endothelial cells in various cancers. Methods: Here, we developed poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) PEGylated with polyethylene glycol (PEG) and fun
Externí odkaz:
https://doaj.org/article/070209d9764d4d2a83fad37400193bcc
Autor:
Julie K. Fierle, Johan Abram-Saliba, Vasileios Atsaves, Matteo Brioschi, Mariastella de Tiani, Patrick Reichenbach, Melita Irving, George Coukos, Steven M. Dunn
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Anti-tumor therapies that seek to exploit and redirect the cytotoxic killing and effector potential of autologous or syngeneic T cells have shown extraordinary promise and efficacy in certain clinical settings. Such cells, when engineered to
Externí odkaz:
https://doaj.org/article/5272d46530e645cbb33e011fe7c50336