Rapid tumor DNA analysis of cerebrospinal fluid accelerates treatment of central nervous system lymphoma.

Autor: Gupta M; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA.; Department of Neurosurgery, University of California San Diego, La Jolla, CA., Bradley JD; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Massaad E; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Burns EJ; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Georgantas NZ; Department of Pathology, Massachusetts General Hospital, Boston, MA., Maron GE; Department of Pathology, Massachusetts General Hospital, Boston, MA., Batten JM; Department of Pathology, Massachusetts General Hospital, Boston, MA., Gallagher A; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Thierauf J; Department of Pathology, Massachusetts General Hospital, Boston, MA.; Department of Otorhinolaryngology, Head and Neck Surgery, Experimental Head and Neck Oncology, Heidelberg University Hospital, Heidelberg, Germany., Nayyar N; Cancer Center, Massachusetts General Hospital, Boston, MA., Gordon A; Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA., Jones SS; Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA., Pisapia M; Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA., Sun Y; Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA., Jones PS; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Barker FG 2nd; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Curry WT; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Gupta R; Department of Neuroradiology, Massachusetts General Hospital, Boston, MA., Romero JM; Department of Neuroradiology, Massachusetts General Hospital, Boston, MA., Wang N; Department of Medicine, Massachusetts General Hospital, Boston, MA., Brastianos PK; Cancer Center, Massachusetts General Hospital, Boston, MA.; Department of Neurology, Massachusetts General Hospital, Boston, MA.; Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA., Martinez-Lage M; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Boston, MA., Tateishi K; Department of Neurosurgery, Yokohama City University, Yokohama, Japan., Forst DA; Cancer Center, Massachusetts General Hospital, Boston, MA., Nahed BV; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Batchelor TT; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA., Ritterhouse LL; Department of Pathology, Massachusetts General Hospital, Boston, MA., Iser F; Department of Neurology and Neuro-Oncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Kessler T; Department of Neurology and Neuro-Oncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Jordan JT; Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA., Dietrich J; Cancer Center, Massachusetts General Hospital, Boston, MA.; Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA., Meyerson M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Lennerz JK; Department of Pathology, Massachusetts General Hospital, Boston, MA., Carter BS; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Shankar GM; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA.

Publikováno v: Blood [Blood] 2024 Sep 05; Vol. 144 (10), pp. 1093-1100.

Slide-to-Slide Tissue Transfer and Array Assembly From Limited Samples for Comprehensive Molecular Profiling.

Autor: Weissinger SE; Institute of Pathology, Alb Fils Clinics GmbH, Göppingen, Germany; Institute of Pathology, University Hospital Ulm, Ulm, Germany., Georgantas NZ; Center for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts., Thierauf JC; Center for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts., Pellerin R; Center for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts., Gardecki E; Center for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts., Kühlinger S; Institute of Pathology, Alb Fils Clinics GmbH, Göppingen, Germany., Ritterhouse LL; Center for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts., Möller P; Institute of Pathology, University Hospital Ulm, Ulm, Germany., Lennerz JK; Center for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts. Electronic address: JLennerz@partners.org.

Publikováno v: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2023 May; Vol. 103 (5), pp. 100062. Date of Electronic Publication: 2023 Jan 18.

Development of a qualitative real-time RT-PCR assay for the detection of SARS-CoV-2: a guide and case study in setting up an emergency-use, laboratory-developed molecular microbiological assay.

Autor: Anahtar MN; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Shaw BM; Infectious Disease and Microbiome Program, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA., Slater D; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA., Byrne EH; Infectious Disease and Microbiome Program, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Botti-Lodovico Y; Infectious Disease and Microbiome Program, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Adams G; Infectious Disease and Microbiome Program, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA., Schaffner SF; Infectious Disease and Microbiome Program, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA., Eversley J; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., McGrath GEG; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA., Gogakos T; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Lennerz J; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Marble HD; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Ritterhouse LL; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Batten JM; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Georgantas NZ; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Pellerin R; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Signorelli S; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Thierauf J; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Otorhinolaryngology, University Hospital Heidelberg, Heidelberg, Baden-Württemberg, Germany., Kemball M; Infectious Disease and Microbiome Program, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA., Happi C; Department of Biological Sciences, Redeemer's University, Ede, Osun, Nigeria.; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun, Nigeria., Grant DS; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Ndiaye D; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun, Nigeria.; Department of Mycology and Pharmacology, Universite Cheikh Anta Diop, Dakar, Senegal., Siddle KJ; Infectious Disease and Microbiome Program, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA., Mehta SB; Infectious Disease and Microbiome Program, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Harris JB; Department of Pediatrics, Massachusetts General Hospital for Children, Boston, Massachusetts, USA., Ryan ET; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA., Pierce VM; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Pediatrics, Massachusetts General Hospital for Children, Boston, Massachusetts, USA., LaRocque RC; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA., Lemieux JE; Infectious Disease and Microbiome Program, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA pardis@broadinstitute.org lemieux@broadinstitute.org Branda.John@mgh.harvard.edu Turbett.Sarah@mgh.harvard.edu.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA., Sabeti PC; Infectious Disease and Microbiome Program, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA pardis@broadinstitute.org lemieux@broadinstitute.org Branda.John@mgh.harvard.edu Turbett.Sarah@mgh.harvard.edu.; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.; Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA., Rosenberg ES; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA., Branda JA; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA pardis@broadinstitute.org lemieux@broadinstitute.org Branda.John@mgh.harvard.edu Turbett.Sarah@mgh.harvard.edu., Turbett SE; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA pardis@broadinstitute.org lemieux@broadinstitute.org Branda.John@mgh.harvard.edu Turbett.Sarah@mgh.harvard.edu.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.

Publikováno v: Journal of clinical pathology [J Clin Pathol] 2021 Aug; Vol. 74 (8), pp. 496-503. Date of Electronic Publication: 2021 May 28.

Development of a qualitative real-time RT-PCR assay for the detection of SARS-CoV-2: A guide and case study in setting up an emergency-use, laboratory-developed molecular assay.

Autor: Anahtar MN; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts., Shaw B; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Slater D; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Byrne E; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Botti-Lodovico Y; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Adams G; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Schaffner S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA., Eversley J; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts., McGrath G; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Gogakos T; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts., Lennerz J; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts., Desai Marble H; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts., Ritterhouse LL; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts., Batten J; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts., Georgantas NZ; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts., Pellerin R; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts., Signorelli S; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts., Thierauf J; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.; Department of Otorhinolaryngology, Head and Neck Surgery, Experimental Head and Neck Oncology, Heidelberg University Hospital, Heidelberg, Germany., Kemball M; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA., Happi C; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria.; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria., Grant DS; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, 1 Combema Road, Kenema, Sierra Leone.; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Ndiaye D; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Université Cheikh Anta Diop, BP 5005, Dakar, Sénégal., Siddle KJ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA., Mehta SB; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA., Harris J; Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA, USA., Ryan ET; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Pierce V; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.; Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA, USA., LaRocque R; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Lemieux JE; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Sabeti P; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Rosenberg E; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Branda J; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts., Turbett SE; Department of Pathology and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2020 Sep 01. Date of Electronic Publication: 2020 Sep 01.

Preoperative Corticosteroids Reduce Diagnostic Accuracy of Stereotactic Biopsies in Primary Central Nervous System Lymphoma: A Systematic Review and Meta-Analysis.

Autor: Tosefsky, Kira, Rebchuk, Alexander D., Chornenka Martin, Karina, Chen, David W., Yip, Stephen, Makarenko, Serge

Publikováno v: Neurosurgery; Oct2024, Vol. 95 Issue 4, p740-750, 11p