Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Georg Steffes"'
A Residual N-Terminal Peptide Enhances Signaling of Depalmitoylated Hedgehog to the Patched Receptor
Autor:
Sophia F. Ehlers, Dominique Manikowski, Georg Steffes, Kristina Ehring, Fabian Gude, Kay Grobe
Publikováno v:
Journal of Developmental Biology, Vol 12, Iss 2, p 11 (2024)
During their biosynthesis, Sonic hedgehog (Shh) morphogens are covalently modified by cholesterol at the C-terminus and palmitate at the N-terminus. Although both lipids initially anchor Shh to the plasma membrane of producing cells, it later translo
Externí odkaz:
https://doaj.org/article/187aca1451a64b67b6f17cfb26846c26
Autor:
Fabian Gude, Jurij Froese, Dominique Manikowski, Daniele Di Iorio, Jean-Noël Grad, Seraphine Wegner, Daniel Hoffmann, Melissa Kennedy, Ralf P. Richter, Georg Steffes, Kay Grobe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The Hedgehog morphogen creates gradients during development, but diffusion alone cannot explain its spatiotemporal dynamics. Hedgehog transport requires binding heparan sulfate sugar chains, and the authors now show that Hedgehogs can spread by inter
Externí odkaz:
https://doaj.org/article/716e902b0b7e4784b0dc71931f62a5e0
Autor:
Dominique Manikowski, Georg Steffes, Jurij Froese, Sebastian Exner, Kristina Ehring, Fabian Gude, Daniele Di Iorio, Seraphine V. Wegner, Kay Grobe
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Morphogens determine cellular differentiation in many developing tissues in a concentration dependent manner. As a central model for gradient formation during animal development, Hedgehog (Hh) morphogens spread away from their source to direct growth
Externí odkaz:
https://doaj.org/article/448be748097d4105af3606a9394999ef
Autor:
Gaurav Goyal, Junfeng Zheng, Elisabeth Adam, Georg Steffes, Mamta Jain, Kristaps Klavins, Thomas Hummel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Little is known about the initial segregation of axonal and dendritic proteins during the differentiation of newly generated neurons. Here authors use a forward genetic screen to identify the role of sphingolipids in regulating the sub-cellular distr
Externí odkaz:
https://doaj.org/article/dac65b4ee54f4d37850c41772c6a9f87
Autor:
Dominique Manikowski, Philipp Kastl, Sabine Schürmann, Kristina Ehring, Georg Steffes, Petra Jakobs, Kay Grobe
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Hedgehog (Hh) morphogens are involved in embryonic development and stem cell biology and, if misregulated, can contribute to cancer. One important post-translational modification with profound impact on Hh biofunction is its C-terminal cholesteroylat
Externí odkaz:
https://doaj.org/article/1948601f900e4a108549ae9bc7bf2a90
Autor:
Sabine Schürmann, Georg Steffes, Dominique Manikowski, Philipp Kastl, Ursula Malkus, Shyam Bandari, Stefanie Ohlig, Corinna Ortmann, Rocio Rebollido-Rios, Mandy Otto, Harald Nüsse, Daniel Hoffmann, Christian Klämbt, Milos Galic, Jürgen Klingauf, Kay Grobe
Publikováno v:
eLife, Vol 7 (2018)
Cell fate determination during development often requires morphogen transport from producing to distant responding cells. Hedgehog (Hh) morphogens present a challenge to this concept, as all Hhs are synthesized as terminally lipidated molecules that
Externí odkaz:
https://doaj.org/article/6a0f74376f5b4faab692c9a25021d50d
Autor:
Sven Niehues, Julia Bussmann, Georg Steffes, Ines Erdmann, Caroline Köhrer, Litao Sun, Marina Wagner, Kerstin Schäfer, Guangxia Wang, Sophia N. Koerdt, Morgane Stum, Sumit Jaiswal, Uttam L. RajBhandary, Ulrich Thomas, Hermann Aberle, Robert W. Burgess, Xiang-Lei Yang, Daniela Dieterich, Erik Storkebaum
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications 6: Article number: 7520 (2015); Published: 3 July 2015; Updated: 21 January 2016. The authors inadvertently omitted Sumit Jaiswal, who was originally included in the Acknowledgements section of this Article and contributed to th
Externí odkaz:
https://doaj.org/article/d78a9b87a531477386b0c8affd38d9a5
Autor:
Georg Steffes, Beatriz Lorente-Cánovas, Selina Pearson, Rachael H Brooker, Sarah Spiden, Amy E Kiernan, Jean-Louis Guénet, Karen P Steel
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e51065 (2012)
Mutanlallemand (mtl) and Belly Spot and Deafness (bsd) are two new spontaneous alleles of the Lmx1a gene in mice. Homozygous mutants show head tossing and circling behaviour, indicative of vestibular defects, and they have short tails and white belly
Externí odkaz:
https://doaj.org/article/463643acdb0c45af869718d1e1c8efc9
Publikováno v:
Biochemical Society Transactions.
Patterns of gene expression, cell growth and cell-type specification during development are often regulated by morphogens. Morphogens are signalling molecules produced by groups of source cells located tens to hundreds of micrometers distant from the
Autor:
Kristina Ehring, Georg Steffes, Kay Grobe, Sabine Schürmann, Dominique Manikowski, Philipp Kastl, Petra Jakobs
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Hedgehog (Hh) morphogens are involved in embryonic development and stem cell biology and, if misregulated, can contribute to cancer. One important post-translational modification with profound impact on Hh biofunction is its C-terminal cholesteroylat