Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Georg Sebastian Hönes"'
Autor:
Helena Kerp, Janina Gassen, Susanne Camilla Grund, Georg Sebastian Hönes, Stefanie Dörr, Jens Mittag, Nina Härting, Frank Kaiser, Lars Christian Moeller, Kristina Lorenz, Dagmar Führer
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionThyroid hormones (THs) are known to have various effects on the cardiovascular system. However, the impact of TH levels on preexisting cardiac diseases is still unclear. Pressure overload due to arterial hypertension or aortic stenosis an
Externí odkaz:
https://doaj.org/article/d63a415a73d242b091129ce12f56a6f1
Autor:
Lisa Roth, Kornelia Johann, Georg Sebastian Hönes, Rebecca Oelkrug, Leonie Wagner, Anne Hoffmann, Knut Krohn, Lars C. Moeller, Juliane Weiner, John T. Heiker, Nora Klöting, Anke Tönjes, Michael Stumvoll, Matthias Blüher, Jens Mittag, Kerstin Krause
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112088- (2023)
Summary: The hypothalamic pituitary thyroid axis is a major regulator of many differentiation processes, including adipose tissue. However, it remains unclear whether and how thyroid hormone (TH) signaling contributes to preadipocyte commitment and d
Externí odkaz:
https://doaj.org/article/741b5f21ce0544cda0bc9d999b796c18
Autor:
Helena Kerp, Georg Sebastian Hönes, Elen Tolstik, Judith Hönes-Wendland, Janina Gassen, Lars Christian Moeller, Kristina Lorenz, Dagmar Führer
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Purpose: Thyroid hormones (TH) play a central role for cardiac function. TH influence heart rate and cardiac contractility, and altered thyroid function is associated with increased cardiovascular morbidity and mortality. The precise role of TH in on
Externí odkaz:
https://doaj.org/article/5c8f5d3052414b1fa1475ecb7c337052
Autor:
Helena Rakov, Kathrin Engels, Georg Sebastian Hönes, Klaudia Brix, Josef Köhrle, Lars Christian Moeller, Denise Zwanziger, Dagmar Führer
Publikováno v:
Biology of Sex Differences, Vol 8, Iss 1, Pp 1-11 (2017)
Abstract Background Sex and age play a role in the prevalence of thyroid dysfunction (TD), but their interrelationship for manifestation of hyper- and hypothyroidism is still not well understood. Using a murine model, we asked whether sex impacts the
Externí odkaz:
https://doaj.org/article/7dd0ede2285a4298b38e7be8fd3a0c32
Autor:
Klaudia Brix, Georg Sebastian Hönes, Josef Köhrle, Kostja Renko, Lars C. Moeller, Dagmar Führer, Helena Kerp
Publikováno v:
Journal of Molecular Endocrinology. 67:161-172
Thyroid hormone (TH) metabolism and cellular TH action are influenced by ageing. To investigate the response to thyroxine (T4) overtreatment, a kinetic study was conducted in young and aged mice with chronic hyperthyroidism and hormone withdrawal. Fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9826d491003652a7de9c30b44424f127
https://doi.org/10.1530/jme-21-0109
https://doi.org/10.1530/jme-21-0109
Autor:
Georg Sebastian Hönes, Ramona Gowry Sivakumar, Christoph Hoppe, Jörg König, Dagmar Führer, Lars Christian Moeller
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 13714
Thyroid hormones (THs) and TH receptor-beta (TRβ) reduce hepatic triglycerides, indicating a therapeutic potential for TH analogs in liver steatosis. To avoid adverse extrahepatic, especially TRα-mediated effects such as tachycardia and bone loss,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505a48558b1449ccedaf34953511d341
https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00077964/ijms_2022_23-13714.pdf
https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00077964/ijms_2022_23-13714.pdf
Publikováno v:
International journal of molecular sciences. 23(13)
Thyroid hormones (THs) control a wide range of physiological functions essential for metabolism, growth, and differentiation. On a molecular level, TH action is exerted by nuclear receptors (TRs), which function as ligand-dependent transcription fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db58d1fcf6e5e7c76a37534a8d600b9
https://pubmed.ncbi.nlm.nih.gov/35806002
https://pubmed.ncbi.nlm.nih.gov/35806002
Autor:
Georg Sebastian Hönes, Helena Kerp, Christoph Hoppe, Manuela Kowalczyk, Denise Zwanziger, Hideo Andreas Baba, Dagmar Führer, Lars Christian Moeller
Context 3,5,3’-L-triiodothyronine (T3) is a potent inducer of hepatocyte proliferation via the Wnt/β-catenin signaling pathway. Previous studies suggested the involvement of rapid noncanonical thyroid hormone receptor (TR) β signaling, directly a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5818266567951b52938ff3814c43343b
https://www.ncbi.nlm.nih.gov/pubmed/35038735
https://www.ncbi.nlm.nih.gov/pubmed/35038735
Autor:
Helena Rakov, Dagmar Führer, Meri De Angelis, Georg Sebastian Hönes, Kostja Renko, Karl-Werner Schramm, Lars C. Moeller, Denise Zwanziger
Publikováno v:
Thyroid 29, 1723-1733 (2019)
Background: Serum thyroid state in older adults correlates with extended longevity. We hypothesized that age impacts not only systemic but also organ-specific thyroid state and response to thyroxine (T4). Methods: Young (3 months) and old (23 months)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca712a41a1afc5b6ff70cb79e920582e
https://doi.org/10.1089/thy.2018.0377
https://doi.org/10.1089/thy.2018.0377
Autor:
Janina Pape, Helena Kerp, Helmut R. Lieder, Daniela Geist, Georg Sebastian Hönes, Lars C. Moeller, Petra Kleinbongard, Dagmar Führer
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13340
OA Förderung 2022 Hypothyroidism has been shown to reduce infarct size in rats, but the underlying mechanisms are unclear. We used isolated pressure-constant perfused hearts of control, hypothyroid and hyperthyroid mice and measured infarct size, fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06148b4f1651e2a4cfbc728c460334c7
https://doi.org/10.3390/ijms232113340
https://doi.org/10.3390/ijms232113340