Combining somatic mutations present in different in vivo affinity-matured antibodies isolated from immunized Lama glama yields ultra-potent antibody therapeutics

Autor: Nico Ongenae, Anna Hultberg, Christian Cambillau, Christophe Blanchetot, Torsten Dreier, Silvia Spinelli, Wieger Hemrika, John Wijdenes, Ava Sadi, Rob C. Roovers, Alex Klarenbeek, Anke Kretz-Rommel, Hans de Haard, Georg Schragel, Aline Desmyter

Publikováno v: Protein Engineering, Design and Selection
Protein Engineering, Design and Selection, Oxford University Press (OUP), 2016, 29 (4), pp.123-133. ⟨10.1093/protein/gzw003⟩
Protein Engineering, Design and Selection, 2016, 29 (4), pp.123-133. ⟨10.1093/protein/gzw003⟩

Highly potent human antibodies are required to therapeutically neutralize cytokines such as interleukin-6 (IL-6) that is involved in many inflammatory diseases and malignancies. Although a number of mutagenesis approaches exist to perform antibody af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49a6a706c7c5b3a85e8c888687bc7cd
https://hal.archives-ouvertes.fr/hal-01439062