Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Georg Petkau"'
Autor:
Peter K Jani, Georg Petkau, Yohei Kawano, Uwe Klemm, Gabriela Maria Guerra, Gitta Anne Heinz, Frederik Heinrich, Pawel Durek, Mir-Farzin Mashreghi, Fritz Melchers
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002015 (2023)
Throughout life, hematopoietic stem cells (HSCs), residing in bone marrow (BM), continuously regenerate erythroid/megakaryocytic, myeloid, and lymphoid cell lineages. This steady-state hematopoiesis from HSC and multipotent progenitors (MPPs) in BM c
Externí odkaz:
https://doaj.org/article/f5721978d1074d5487f1c9dc30066fbd
Autor:
Louise S. Matheson, Georg Petkau, Beatriz Sáenz-Narciso, Vanessa D’Angeli, Jessica McHugh, Rebecca Newman, Haydn Munford, James West, Krishnendu Chakraborty, Jennie Roberts, Sebastian Łukasiak, Manuel D. Díaz-Muñoz, Sarah E. Bell, Sarah Dimeloe, Martin Turner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-24 (2022)
Abstract The ZFP36 family of RNA-binding proteins acts post-transcriptionally to repress translation and promote RNA decay. Studies of genes and pathways regulated by the ZFP36 family in CD4+ T cells have focussed largely on cytokines, but their impa
Externí odkaz:
https://doaj.org/article/502be5987af14790b105142b3363eb12
Autor:
Georg Petkau, Twm J. Mitchell, Krishnendu Chakraborty, Sarah E. Bell, Vanessa D´Angeli, Louise Matheson, David J. Turner, Alexander Saveliev, Ozge Gizlenci, Fiamma Salerno, Peter D. Katsikis, Martin Turner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
RNA binding proteins (RBP) have a function in T cell activation and differentiation. Here the authors show that in the absence of two RBPs, ZFP36 and ZFP36L1, T cells acquire more rapidly superior effector capabilities, showing a limiting function fo
Externí odkaz:
https://doaj.org/article/c032f41db1e44009b03c5865b008dfa8
Autor:
Rebecca Cornelis, Stefanie Hahne, Adriano Taddeo, Georg Petkau, Darya Malko, Pawel Durek, Manja Thiem, Lukas Heiberger, Lena Peter, Elodie Mohr, Cora Klaeden, Koji Tokoyoda, Francesco Siracusa, Bimba Franziska Hoyer, Falk Hiepe, Mir-Farzin Mashreghi, Fritz Melchers, Hyun-Dong Chang, Andreas Radbruch
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107982- (2020)
Summary: The persistence of long-lived memory plasma cells in the bone marrow depends on survival factors available in the bone marrow, which are provided in niches organized by stromal cells. Using an ex vivo system in which we supply the known surv
Externí odkaz:
https://doaj.org/article/98a5523b3ebf485e83c35f6851db7f1b
Autor:
David Reismann, Jonathan Stefanowski, Robert Günther, Asylkhan Rakhymzhan, Romano Matthys, Reto Nützi, Sandra Zehentmeier, Katharina Schmidt-Bleek, Georg Petkau, Hyun-Dong Chang, Sandra Naundorf, York Winter, Fritz Melchers, Georg Duda, Anja E. Hauser, Raluca A. Niesner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Longitudinal imaging of bone marrow would shed insight into long-term cellular dynamics within this compartment. Here, the authors develop a multi-photon imaging approach for the mouse femur and reveal extensive vascular plasticity within the bone ma
Externí odkaz:
https://doaj.org/article/5461e2efd91248698ccbbea37bccb7fc
Autor:
Georg Petkau, Twm J. Mitchell, Marian Jones Evans, Louise Matheson, Fiamma Salerno, Martin Turner
How individual T cells compete for and respond to IL2 at the molecular level, and, as a consequence, how this shapes population dynamics and the selection of high affinity clones is still poorly understood. Here we describe how the RNA binding protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::370e2d9f17a519ce44391fdff8552597
https://doi.org/10.1101/2023.05.11.539978
https://doi.org/10.1101/2023.05.11.539978
Autor:
Vanessa D’Angeli, Elisa Monzón-Casanova, Louise S. Matheson, Özge Gizlenci, Georg Petkau, Clare Gooding, Rebecca V. Berrens, Christopher W. J. Smith, Martin Turner
Publikováno v:
European Journal of Immunology. 52:1058-1068
The RNA-binding protein polypyrimidine tract binding protein 1 (PTBP1) has been found to have roles in CD4 T-cell activation, but its function in CD8 T cells remains untested. We show it is dispensable for the development of naïve mouse CD8 T cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6177636ea190a0e34eb80d74763e8212
https://doi.org/10.1002/eji.202149781
https://doi.org/10.1002/eji.202149781
Autor:
Peter K. Jani, Georg Petkau, Yohei Kawano, Uwe Klemm, Gabriela Maria Guerra, Gitta Anne Heinz, Frederik Heinrich, Pawel Durek, Mir-Farzin Mashreghi, Fritz Melchers
The microRNA cluster-221/222 is expressed in hematopoietic stem cells (HSC) and multipotent progenitors (MPP). To study its function in hematopoiesis, we generated mice, in which this cluster is selectively deleted by Vav-cre in HSC and, thus, in all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7700e0686ea238d5b279846330ade0e7
https://doi.org/10.1101/2023.01.30.526397
https://doi.org/10.1101/2023.01.30.526397
Autor:
null Vanessa D'Angeli, null Elisa Monzón‐Casanova, null Louise S. Matheson, null Özge Gizlenci, null Georg Petkau, null Clare Gooding, null Rebecca V. Berrens, null Christopher W. J. Smith, null Martin Turner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36b2140cf08aefb50350ca4671c26ca7
https://doi.org/10.1002/eji.202149781/v3/response1
https://doi.org/10.1002/eji.202149781/v3/response1
Autor:
Georg Petkau, Martin R Turner
Publikováno v:
Biochemical Journal. 476:769-778
In mammals, the B-cell lineage arises from pluripotent progenitors in the bone marrow. During their development, B-cells undergo lineage specification and commitment, followed by expansion and selection. These processes are mediated by regulated chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4839ae945fd8b643961d3f331bdacefb
https://doi.org/10.1042/bcj20180565
https://doi.org/10.1042/bcj20180565