Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Georg Langlhofer"'
Autor:
Ulrike Breitinger, Kristina Weinländer, Yvonne Pechmann, Georg Langlhofer, Ralf Enz, Cord-Michael Becker, Heinrich Sticht, Matthias Kneussel, Carmen Villmann, Hans-Georg Breitinger
Publikováno v:
Journal of Advanced Research, Vol 29, Iss , Pp 95-106 (2021)
Introduction: The inhibitory glycine receptor (GlyR), a mediator of fast synaptic inhibition, is located and held at neuronal synapses through the anchoring proteins gephyrin and collybistin. Stable localization of neurotransmitter receptors is essen
Externí odkaz:
https://doaj.org/article/b4853887700343baa11b04360ae43b22
Autor:
Matthias Kneussel, Ralf Enz, Ulrike Breitinger, Kristina Weinländer, Cord-Michael Becker, Heinrich Sticht, Yvonne Pechmann, Carmen Villmann, Hans-Georg Breitinger, Georg Langlhofer
Publikováno v:
Journal of Advanced Research, Vol 29, Iss, Pp 95-106 (2021)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Introduction The inhibitory glycine receptor (GlyR), a mediator of fast synaptic inhibition, is located and held at neuronal synapses through the anchoring proteins gephyrin and collybistin. Stable localization of neurotransmi
Introduction The inhibitory glycine receptor (GlyR), a mediator of fast synaptic inhibition, is located and held at neuronal synapses through the anchoring proteins gephyrin and collybistin. Stable localization of neurotransmi
Publikováno v:
Cell calcium. 99
Electrical activity and oscillations of cytosolic Ca2+ concentrations ([Ca2+]i) that trigger insulin release in response to glucose are key functions of pancreatic β cells. Although oscillatory Ca2+ signals have been intensively studied in β cells,
Autor:
Britta Wachter, Patrick Lüningschrör, Camelia M. Monoranu, Jochen Kuper, Elena Bady, Dennis Segebarth, Gisela Wohlleben, Bülent Polat, Rohini Gupta, Robert Blum, Melanie Bauer, Vanessa Luzak, Carmen Villmann, Steven Havlicek, Vanessa Wegat, Georg Langlhofer
Trk receptors and gene fusions of NTRK are targets in precision oncology. Classical Trk signalling concepts fail to explain ligand-independent signalling of intracellular TrkB or NTRK fusion proteins. Here, we show that abundance of the intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409f5e480533197bebb221e91ef20742
https://doi.org/10.1101/2020.09.11.292565
https://doi.org/10.1101/2020.09.11.292565
Autor:
Carmen Villmann, Dennis Koch, Natascha Schaefer, Britta Qualmann, Hans Michael Maric, Angelo Keramidas, Yan Zhang, Hans-Georg Breitinger, Michael M. Kessels, Peter Baumann, Ulrike Breitinger, Andreas Schlosser, Joseph W. Lynch, Georg Langlhofer, Kristian Strømgaard, Robert Blum
Publikováno v:
J Neurosci
Langlhofer, G, Schaefer, N, Maric, H M, Keramidas, A, Zhang, Y, Baumann, P, Blum, R, Breitinger, U, Strømgaard, K, Schlosser, A, Kessels, M M, Koch, D, Qualmann, B, Breitinger, H G, Lynch, J W & Villmann, C 2020, ' A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition ', Journal of Neuroscience, vol. 40, no. 25, pp. 4954-4969 . https://doi.org/10.1523/JNEUROSCI.2490-19.2020
Langlhofer, G, Schaefer, N, Maric, H M, Keramidas, A, Zhang, Y, Baumann, P, Blum, R, Breitinger, U, Strømgaard, K, Schlosser, A, Kessels, M M, Koch, D, Qualmann, B, Breitinger, H G, Lynch, J W & Villmann, C 2020, ' A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition ', Journal of Neuroscience, vol. 40, no. 25, pp. 4954-4969 . https://doi.org/10.1523/JNEUROSCI.2490-19.2020
Glycine receptors (GlyRs) are the major mediators of fast synaptic inhibition in the adult human spinal cord and brainstem. Hereditary mutations to GlyRs can lead to the rare, but potentially fatal, neuromotor disorder hyperekplexia. Most mutations l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9b1e86a6fa1c62abae0839fc058d1c
https://europepmc.org/articles/PMC7326357/
https://europepmc.org/articles/PMC7326357/
Publikováno v:
Neuroscience Letters. 600:176-181
Recent studies on the molecular determinants important for glycine receptor biogenesis and function mechanisms indicate an important role of basic residues within the intracellular loop between transmembrane domains (TM) 3 and 4. We investigate the r
Autor:
Carmen Villmann, Georg Langlhofer
Publikováno v:
Journal of neurochemistry. 142(1)
Glycine receptor (GlyR) truncations in the intracellular TM3-4 loop, documented in patients suffering from hyperekplexia and in the mouse mutant oscillator, lead to non-functionality of GlyRs. The missing part that contains the TM3-4 loop, TM4 and C-
Publikováno v:
British Journal of Pharmacology. 170:933-952
Human hyperekplexia is a neuromotor disorder caused by disturbances in inhibitory glycine-mediated neurotransmission. Mutations in genes encoding for glycine receptor subunits or associated proteins, such as GLRA1, GLRB, GPHN and ARHGEF9, have been d
Autor:
Carmen Villmann, Georg Langlhofer
Publikováno v:
Frontiers in Molecular Neuroscience
The family of Cys-loop receptors (CLRs) shares a high degree of homology and sequence identity. The overall structural elements are highly conserved with a large extracellular domain (ECD) harboring an α-helix and 10 β-sheets. Following the ECD, fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fb52b49ad80e503859e675aadfe7a2
https://opus.bibliothek.uni-wuerzburg.de/files/16539/Langlhofer_Frontiers_Molecular_Neuroscience_2016.pdf
https://opus.bibliothek.uni-wuerzburg.de/files/16539/Langlhofer_Frontiers_Molecular_Neuroscience_2016.pdf
Autor:
Stephan Schwarzinger, Natascha Schaefer, Christoph J. Kluck, Sarah C. R. Lummis, Solveig Schulz, Cord-Michael Becker, Nadine Vornberger, Georg Langlhofer, Carmen Villmann, Kerry L. Price, Bryan Lynch, Knut Brockmann, Nadja Schlegel, Stephanie Hartmann, Heike Meiselbach
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(1)
Recent studies on the pathogenic mechanisms of recessive hyperekplexia indicate disturbances in glycine receptor (GlyR) α1 biogenesis. Here, we examine the properties of a range of novel glycine receptor mutants identified in human hyperekplexia pat