Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Georg L, Goebel"'
Publikováno v:
JACS Au, Vol 4, Iss 4, Pp 1436-1449 (2024)
Externí odkaz:
https://doaj.org/article/daf34c1e07fe4dec99751c6fc3a64d97
Publikováno v:
Trends in Pharmacological Sciences. 43:866-881
Kinases are among the most successful drug targets. To date, 72 small-molecule kinase inhibitors (SMKIs) have been approved by the US FDA, together with ~500 SMKIs in clinical trials. Although the topic has been heavily reviewed in recent years, an o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e3b1c2e25d962d9890ec1c8d797882
https://doi.org/10.1016/j.tips.2022.04.006
https://doi.org/10.1016/j.tips.2022.04.006
Publikováno v:
ChemBioChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325d95ed377de7ed93e721def7bc25bb
https://doi.org/10.1002/cbic.202300168
https://doi.org/10.1002/cbic.202300168
Autor:
Pascal Hommen, Jimin Hwang, Peng Wu, Lydia Borgelt, Sonja Sievers, Georg L. Goebel, Fu Li, Philipp Lampe
Publikováno v:
ACS Medicinal Chemistry Letters. 12:893-898
Modulation of protein-RNA interaction (PRI) using small molecules is a promising strategy to develop therapeutics. LIN28 is an RNA-binding protein that blocks the maturation of the tumor suppressor let-7 microRNAs. Herein, we performed a fluorescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7b7b073d51cec684d57ed902e5a7c4a
https://doi.org/10.1021/acsmedchemlett.0c00546
https://doi.org/10.1021/acsmedchemlett.0c00546
Autor:
Xiaqiu Qiu, Lydia Borgelt, Georg L. Goebel, Peng Wu, Helen L. Lightfoot, Pascal Hommen, Lisa Hohnen
Publikováno v:
European journal of medicinal chemistry. 228
Inhibition of the RNA-binding protein LIN28 and disruption of the protein–RNA interaction of LIN28–let-7 with small molecules holds great potential to develop new anticancer therapeutics. Herein, we report the LIN28 inhibitory activities of a ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f83d1854ff09891f0c7be3b1544a453
https://pubmed.ncbi.nlm.nih.gov/34883291
https://pubmed.ncbi.nlm.nih.gov/34883291
Autor:
Lydia, Borgelt, Fu, Li, Pascal, Hommen, Philipp, Lampe, Jimin, Hwang, Georg L, Goebel, Sonja, Sievers, Peng, Wu
Publikováno v:
ACS Medicinal Chemistry Letters
Modulation of protein–RNA interaction (PRI) using small molecules is a promising strategy to develop therapeutics. LIN28 is an RNA-binding protein that blocks the maturation of the tumor suppressor let-7 microRNAs. Herein, we performed a fluorescen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd1c4bdb465d01c8581dd39d5c095fac
https://pubmed.ncbi.nlm.nih.gov/34136077
https://pubmed.ncbi.nlm.nih.gov/34136077