Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Georg Kustatscher"'
Autor:
Natalia Y. Kochanova, Petra Vizjak, Maria Alba Abad, William C. Earnshaw, A. Arockia Jeyaprakash, Georg Kustatscher
Publikováno v:
Wellcome Open Research, Vol 8 (2024)
Background Unicorn™ software on Äkta liquid chromatography instruments outputs chromatography profiles of purified biological macromolecules. While the plots generated by the instrument software are very helpful to inspect basic chromatogram prope
Externí odkaz:
https://doaj.org/article/ee935080b91b48e3bb133dcad9ca0ad1
Autor:
Georg Kustatscher, Martina Hödl, Edward Rullmann, Piotr Grabowski, Emmanuel Fiagbedzi, Anja Groth, Juri Rappsilber
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 5, Pp 1-14 (2023)
Abstract Operons are transcriptional modules that allow bacteria to adapt to environmental changes by coordinately expressing the relevant set of genes. In humans, biological pathways and their regulation are more complex. If and how human cells coor
Externí odkaz:
https://doaj.org/article/ffe5da9b79184787931496bfe0793bde
Autor:
Natalia Y. Kochanova, Petra Vizjak, Maria Alba Abad, William C. Earnshaw, A. Arockia Jeyaprakash, Georg Kustatscher
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: UnicornTM software on Äkta liquid chromatography instruments outputs chromatography profiles of purified biological macromolecules. While the plots generated by the instrument software are very helpful to inspect basic chromatogram prope
Externí odkaz:
https://doaj.org/article/e04a79c7246140bdb577940e882246dc
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 8, Pp 1-14 (2017)
Abstract Genes are not randomly distributed in the genome. In humans, 10% of protein‐coding genes are transcribed from bidirectional promoters and many more are organised in larger clusters. Intriguingly, neighbouring genes are frequently coexpress
Externí odkaz:
https://doaj.org/article/e2943f44803e47ba9a9b5bfb7009ddd7
Autor:
Christoph B. Messner, Vadim Demichev, Julia Muenzner, Simran K. Aulakh, Natalie Barthel, Annika Röhl, Lucía Herrera-Domínguez, Anna-Sophia Egger, Stephan Kamrad, Jing Hou, Guihong Tan, Oliver Lemke, Enrica Calvani, Lukasz Szyrwiel, Michael Mülleder, Kathryn S. Lilley, Charles Boone, Georg Kustatscher, Markus Ralser
Publikováno v:
Cell
Messner, C B, Demichev, V, Muenzner, J, Aulakh, S K, Barthel, N, Röhl, A, Herrera-Domínguez, L, Egger, A, Kamrad, S, Hou, J, Tan, G, Lemke, O, Calvani, E, Szyrwiel, L, Mülleder, M, Lilley, K S, Boone, C, Kustatscher, G & Ralser, M 2023, ' The proteomic landscape of genome-wide genetic perturbations ', Cell, vol. 186, no. 9 . https://doi.org/10.1016/j.cell.2023.03.026
Messner, C B, Demichev, V, Muenzner, J, Aulakh, S K, Barthel, N, Röhl, A, Herrera-Domínguez, L, Egger, A, Kamrad, S, Hou, J, Tan, G, Lemke, O, Calvani, E, Szyrwiel, L, Mülleder, M, Lilley, K S, Boone, C, Kustatscher, G & Ralser, M 2023, ' The proteomic landscape of genome-wide genetic perturbations ', Cell, vol. 186, no. 9 . https://doi.org/10.1016/j.cell.2023.03.026
Functional genomic strategies have become fundamental for annotating gene function and regulatory networks. Here, we combined functional genomics with proteomics by quantifying protein abundances in a genome-scale knockout library in Saccharomyces ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2d60b8045d42b55731221ebbf452f9
https://hdl.handle.net/21.11116/0000-000D-2B00-321.11116/0000-000D-2B02-1
https://hdl.handle.net/21.11116/0000-000D-2B00-321.11116/0000-000D-2B02-1
Autor:
Georg Kustatscher, Tom Collins, Anne-Claude Gingras, Tiannan Guo, Henning Hermjakob, Trey Ideker, Kathryn S. Lilley, Emma Lundberg, Edward M. Marcotte, Markus Ralser, Juri Rappsilber
Publikováno v:
Kustatscher, G, Collins, T, Gingras, A-C, Guo, T, Hermjakob, H, Ideker, T, Lilley, K S, Lundberg, E, Marcotte, E M, Ralser, M & Rappsilber, J 2022, ' An open invitation to the understudied proteins initiative ', Nature Biotechnology, vol. 40, no. 6, pp. 815-817 . https://doi.org/10.1038/s41587-022-01316-z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b969d80ebe318cc7261269dc1ef3a48f
https://doi.org/10.1038/s41587-022-01316-z
https://doi.org/10.1038/s41587-022-01316-z
Autor:
Georg Kustatscher, Tom Collins, Anne-Claude Gingras, Tiannan Guo, Henning Hermjakob, Trey Ideker, Kathryn S. Lilley, Emma Lundberg, Edward M. Marcotte, Markus Ralser, Juri Rappsilber
Publikováno v:
Kustatscher, G, Collins, T, Gingras, A-C, Guo, T, Hermjakob, H, Ideker, T, Lilley, K S, Lundberg, E, Marcotte, E M, Ralser, M & Rappsilber, J 2022, ' Understudied proteins : Opportunities and challenges for functional proteomics ', Nature Methods, vol. 19, pp. 774-779 . https://doi.org/10.1038/s41592-022-01454-x
Most research aiming at understanding the molecular foundations of life and disease has focused on a limited set of increasingly well-known proteins while the biological functions of many others remain poorly understood. We propose to form the Unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b622a67bd39711fa1b70b183550e8c
https://pubmed.ncbi.nlm.nih.gov/35534633
https://pubmed.ncbi.nlm.nih.gov/35534633
Autor:
Kumiko Samejima, Christos Spanos, Samejima I, Georg Kustatscher, Juri Rappsilber, William C. Earnshaw
Publikováno v:
Samejima, I, Spanos, C, Samejima, K, Rappsilber, J, Kustatscher, G & Earnshaw, W C 2022, ' Mapping the invisible chromatin transactions of prophase chromosome remodelling ', Molecular Cell, vol. 82, no. 3, pp. 696-708.E4 . https://doi.org/10.1016/j.molcel.2021.12.039
Samejima, I, Spanos, C, Samejima, K, Rappsilber, J, Kustatscher, G & Earnshaw, W C 2022, ' Mapping the invisible chromatin transactions of prophase chromosome remodeling ', Molecular Cell, vol. 82, no. 3, pp. 696-708.e4 . https://doi.org/10.1016/j.molcel.2021.12.039
Samejima, I, Spanos, C, Samejima, K, Rappsilber, J, Kustatscher, G & Earnshaw, W C 2022, ' Mapping the invisible chromatin transactions of prophase chromosome remodeling ', Molecular Cell, vol. 82, no. 3, pp. 696-708.e4 . https://doi.org/10.1016/j.molcel.2021.12.039
SUMMARYWe have used a combination of chemical genetics, chromatin proteomics and imaging to map the earliest chromatin transactions during vertebrate cell entry into mitosis. Chicken DT40 CDK1as cells undergo synchronous mitotic entry within 15 minut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6b91f29925b8a924603ca40190a2aa
https://doi.org/10.2139/ssrn.3882890
https://doi.org/10.2139/ssrn.3882890
Autor:
Georg Kustatscher
Publikováno v:
Futurum Careers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::875fec4844a9b4c2a6468732b92794ad
https://doi.org/10.33424/futurum174
https://doi.org/10.33424/futurum174
Publikováno v:
Kelly, V, Al-Rawi, A, Lewis, D, Kustatscher, G & Ly, T 2022, ' Low cell number proteomic analysis using in-cell protease digests reveals a robust signature for cell cycle state classification ', Molecular and Cellular Proteomics, vol. 21, no. 1, 100169 . https://doi.org/10.1016/j.mcpro.2021.100169
Molecular & Cellular Proteomics : MCP
Molecular & Cellular Proteomics : MCP
Comprehensive proteome analysis of rare cell phenotypes remains a significant challenge. We report a method for low cell number MS-based proteomics using protease digestion of mildly formaldehyde-fixed cells in cellulo, which we call the “in-cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9f08dd143b45d961982ffdce6ad432
https://doi.org/10.1016/j.mcpro.2021.100169
https://doi.org/10.1016/j.mcpro.2021.100169