Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Georg Kraal"'
Autor:
Katka Franke, Saravanan Y. Pillai, Mark Hoogenboezem, Marion J. J. Gijbels, Hanke L. Matlung, Judy Geissler, Hugo Olsman, Chantal Pottgens, Patrick J. van Gorp, Maria Ozsvar-Kozma, Yasuyuki Saito, Takashi Matozaki, Taco W. Kuijpers, Rudi W. Hendriks, Georg Kraal, Christoph J. Binder, Menno P. J. de Winther, Timo K. van den Berg
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The inhibitory immunoreceptor SIRPα is expressed on myeloid and neuronal cells and interacts with the broadly expressed CD47. CD47-SIRPα interactions form an innate immune checkpoint and its targeting has shown promising results in cancer patients.
Externí odkaz:
https://doaj.org/article/ee6a819bfd8145e18c05d69a81a9717a
SIRPα Controls the Activity of the Phagocyte NADPH Oxidase by Restricting the Expression of gp91phox
Autor:
Ellen M. van Beek, Julian Alvarez Zarate, Robin van Bruggen, Karin Schornagel, Anton T.J. Tool, Takashi Matozaki, Georg Kraal, Dirk Roos, Timo K. van den Berg
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 748-755 (2012)
The phagocyte NADPH oxidase mediates oxidative microbial killing in granulocytes and macrophages. However, because the reactive oxygen species produced by the NADPH oxidase can also be toxic to the host, it is essential to control its activity. Littl
Externí odkaz:
https://doaj.org/article/e8e2a562a66b4926b2827ae201fb8dd2
Autor:
Mathijs Groeneweg, Edwin Kanters, Monique N. Vergouwe, Hilde Duerink, Georg Kraal, Marten H. Hofker, Menno P.J. de Winther
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 10, Pp 2259-2267 (2006)
Uptake of modified lipoproteins by macrophages results in the formation of foam cells. We investigated how foam cell formation affects the inflammatory response of macrophages. Murine bone marrow-derived macrophages were treated with oxidized LDL (ox
Externí odkaz:
https://doaj.org/article/ea62037277284d128a1181159c8ef884
Autor:
Katka Franke, Saravanan Y. Pillai, Mark Hoogenboezem, Marion J. J. Gijbels, Hanke L. Matlung, Judy Geissler, Hugo Olsman, Chantal Pottgens, Patrick J. van Gorp, Maria Ozsvar-Kozma, Yasuyuki Saito, Takashi Matozaki, Taco W. Kuijpers, Rudi W. Hendriks, Georg Kraal, Christoph J. Binder, Menno P. J. de Winther, Timo K. van den Berg
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, 11:570963. Frontiers Media S.A.
Frontiers in Immunology, Vol 11 (2020)
Frontiers in immunology, 11:570963. Frontiers Media S.A.
Frontiers in Immunology, 11:570963. Frontiers Media S.A.
Frontiers in Immunology, Vol 11 (2020)
Frontiers in immunology, 11:570963. Frontiers Media S.A.
The inhibitory immunoreceptor SIRP alpha is expressed on myeloid and neuronal cells and interacts with the broadly expressed CD47. CD47-SIRP alpha interactions form an innate immune checkpoint and its targeting has shown promising results in cancer p
Autor:
Roy L.J. van Wanrooij, Antonie Zwiers, Petula Nijeboer, G. Bouma, Georg Kraal, Tessa Dieckman
Publikováno v:
Gene, 726:144165. Elsevier
Zwiers, A, van Wanrooij, R L J, Dieckman, T, Nijeboer, P, Kraal, G & Bouma, G 2020, ' Celiac disease associated SNP rs17810546 is located in a gene silencing region ', Gene, vol. 726, 144165 . https://doi.org/10.1016/j.gene.2019.144165
Zwiers, A, van Wanrooij, R L J, Dieckman, T, Nijeboer, P, Kraal, G & Bouma, G 2020, ' Celiac disease associated SNP rs17810546 is located in a gene silencing region ', Gene, vol. 726, 144165 . https://doi.org/10.1016/j.gene.2019.144165
GWAS studies have identified variant rs 17810546 in a non-coding region on chromosome 3 as a risk factor for several auto-immune diseases, including Celiac Disease. In silico analysis reveals that this variant is located in a transcription regulatory
Autor:
Gerd Bouma, Lisa C. Laan, Elsenoor J. Klaver, Richard D. Cummings, I. van Die, T C T M van der Pouw Kraan, Helene Kringel, Georg Kraal
Publikováno v:
Genes and Immunity, 16(6), 378-387
Klaver, E J, van der Pouw-Kraan, T C T M, Laan, L C, Kringel, H, Cummings, R D, Bouma, G, Kraal, G & van Die, I 2015, ' Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells ', Genes and Immunity, vol. 16, no. 6, pp. 378-387 . https://doi.org/10.1038/gene.2015.18
Klaver, E J, van der Pouw-Kraan, T C T M, Laan, L C, Kringel, H, Cummings, R D, Bouma, G, Kraal, G & van Die, I 2015, ' Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells ', Genes and Immunity, vol. 16, no. 6, pp. 378-387 . https://doi.org/10.1038/gene.2015.18
Inflammatory immune disorders such as inflammatory bowel disease and multiple sclerosis are major health problems. Currently, the intestinal whipworm Trichuris suis is being explored in clinical trials to reduce inflammation in these diseases; howeve
Autor:
Timo K. van den Berg, Katka Szilagyi, Georg Kraal, Marion J.J. Gijbels, Sigrid E.M. Heinsbroek, Saskia van der Velden, Menno P.J. de Winther
Publikováno v:
Szilagyi, K, Gijbels, M J J, van der Velden, S, Heinsbroek, S E M, Kraal, G, de Winther, M P J & van den Berg, T K 2015, ' Dectin-1 deficiency does not affect atherosclerosis development in mice ', Atherosclerosis, vol. 239, no. 2, pp. 318-321 . https://doi.org/10.1016/j.atherosclerosis.2015.02.005
Atherosclerosis, 239(2), 318-321. Elsevier Ireland Ltd
Atherosclerosis, 239(2), 318-321. Elsevier Ireland Ltd
Objective Recent data suggest the involvement of dectin-1 in atherosclerosis through regulation of local reactive oxygen species production. The aim of the current study was to assess the effect of dectin-1 deficiency on atherosclerotic plaque develo
Antigen targeting reveals splenic CD169+macrophages as promoters of germinal center B-cell responses
Autor:
Ellen G F Borg, Joke M. M. den Haan, Yvette van Kooyk, Henrike Veninga, Georg Kraal, Hakan Kalay, Luisa Martinez-Pomares, Kyle Vreeman, Philip R. Taylor
Publikováno v:
European Journal of Immunology. 45:747-757
Ag delivery to specific APCs is an attractive approach in developing strategies for vaccination. CD169+ macrophages in the marginal zone of the spleen represent a suitable target for delivery of Ag because of their strategic location, which is optima
Autor:
Gerd Bouma, Joke M. M. den Haan, Marye M. Hogenboom, Georg Kraal, Ida H. Hiemstra, Kim Vrijland
Publikováno v:
Hiemstra, I H, Vrijland, K, Hogenboom, M M, Bouma, G, Kraal, G & den Haan, J M M 2015, ' Intestinal epithelial cell transported TLR2 ligand stimulates Ly6C(+) monocyte differentiation in a G-CSF dependent manner ', Immunobiology, vol. 220, no. 11, pp. 1255-1265 . https://doi.org/10.1016/j.imbio.2015.06.015
Immunobiology, 220(11), 1255-1265. Urban und Fischer Verlag GmbH und Co. KG
Immunobiology, 220(11), 1255-1265. Urban und Fischer Verlag GmbH und Co. KG
Microflora-induced TLR signaling in the intestinal epithelium is essential for a proper intestinal barrier function. Because of the close interactions of this epithelial layer with underlying mononuclear phagocytes, we hypothesized that epithelial TL
Autor:
Lilian F. de Ruiter, Michiel Kleerebezem, Pieter P. E. van Lierop, Sahar El Aidy, Johan C. de Jongste, Beatrix E Elink-Schuurman, Michael Groeneweg, Janneke N. Samsom, Jeroen Hol, Y. Simons-Oosterhuis, Georg Kraal, Celia L Menckeberg, H Rolien C Raatgeep, Anita M. Korteland-van Male, Edward E. S. Nieuwenhuis, Dicky J. Lindenbergh-Kortleve
Publikováno v:
Gut 64 (2015)
ResearcherID
Gut, 64(6), 884-893. BMJ PUBLISHING GROUP
Gut, 64(6), 884-893. BMJ Publishing Group
Menckeberg, C, Hol, J, Simons-Oosterhuis, Y, Raatgeep, H, de Ruiter, L, Lindenbergh-Kortleve, D, Korteland-van Male, A, El Aidy, S, van Lierop, P, Kleerebezem, M, Groeneweg, M, Kraal, G, Elink-Schuurman, B, de Jongste, J, Nieuwenhuis, E & Samsom, J 2015, ' Human buccal epithelium acquires microbial hyporesponsiveness at birth, a role for secretory leukocyte protease inhibitor ', Gut, vol. 64, no. 6, pp. 884-893 . https://doi.org/10.1136/gutjnl-2013-306149
Gut, 64, 884-893
ResearcherID
Gut, 64(6), 884-893. BMJ PUBLISHING GROUP
Gut, 64(6), 884-893. BMJ Publishing Group
Menckeberg, C, Hol, J, Simons-Oosterhuis, Y, Raatgeep, H, de Ruiter, L, Lindenbergh-Kortleve, D, Korteland-van Male, A, El Aidy, S, van Lierop, P, Kleerebezem, M, Groeneweg, M, Kraal, G, Elink-Schuurman, B, de Jongste, J, Nieuwenhuis, E & Samsom, J 2015, ' Human buccal epithelium acquires microbial hyporesponsiveness at birth, a role for secretory leukocyte protease inhibitor ', Gut, vol. 64, no. 6, pp. 884-893 . https://doi.org/10.1136/gutjnl-2013-306149
Gut, 64, 884-893
Objective Repetitive interaction with microbial stimuli renders epithelial cells (ECs) hyporesponsive to microbial stimulation. Previously, we have reported that buccal ECs from a subset of paediatric patients with Crohn9s disease are not hyporespons