Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Georg Heinkele"'
Autor:
Svitlana Igel, Thomas E. Mürdter, Reinhold Kerb, Matthias Schwab, Patrick Kröner, Georg Heinkele
Publikováno v:
Talanta. 221:121658
Clomiphene citrate is first line therapy of female infertility but is also frequently abused by athletes. Human biotransformation of clomiphene results in numerous phase 1 and phase 2 metabolites. The involvement of the polymorphic cytochrome P450 2D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41f45bced66d30ad73409edc8fa49a1
https://doi.org/10.1016/j.talanta.2020.121658
https://doi.org/10.1016/j.talanta.2020.121658
Autor:
Georg Heinkele, Jana C. Precht, Matthias Schwab, Michel Eichelbaum, Hiltrud Brauch, Werner Schroth, Janina Johänning, Thomas E. Mürdter
Publikováno v:
Analytical and Bioanalytical Chemistry. 407:7497-7502
Tamoxifen is a mainstay in the treatment of estrogen receptor-positive breast cancer and is metabolized to more than 30 different compounds. Little is known about in vivo concentrations of estrogenic metabolites E-metabolite E, Z-metabolite E, and bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d10265cba912937d18a951bab1e5e5e
https://doi.org/10.1007/s00216-015-8907-8
https://doi.org/10.1007/s00216-015-8907-8
Autor:
Stephan Urban, Thomas E. Mürdter, Georg Heinkele, Ute Hofmann, Matthias Schwab, A. Alexandrov, Walter E. Haefeli, Mathias Haag, Antje Blank, Patrick Leuthold
Publikováno v:
Analytical and Bioanalytical Chemistry. 407:6815-6825
A novel analytical approach for the targeted profiling of bile acids (BAs) in human serum/plasma based on liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) is presented. Reversed-phase chromatography enabled the baseline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4786a7582e3cd0989459834657c39e92
https://doi.org/10.1007/s00216-015-8853-5
https://doi.org/10.1007/s00216-015-8853-5
Autor:
Matthias Schwab, Michael Lämmerhofer, Ute Hofmann, Mirjam C. K. Geditz, Michael Ramharter, Reinhold Kerb, Wolfgang Lindner, Georg Heinkele
Publikováno v:
Journal of Chromatography B. 968:32-39
Mefloquine (MQ), a racemic mixture of (+)-(11S,12R)- and (-)-(11R,12S)-MQ, has been used for treatment and prophylaxis of malaria for almost 30 years. MQ is metabolized by the cytochrome P450 3A subfamily to 4-carboxymefloquine (CMQ), which shows no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21eba9fa494d1f066d59cfa686005735
https://doi.org/10.1016/j.jchromb.2013.11.035
https://doi.org/10.1016/j.jchromb.2013.11.035
Autor:
Thomas E. Mürdter, Reinhold Kerb, Georg Heinkele, Boian Ganchev, Mirjam C. K. Geditz, Ute Hofmann
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 57:699-703
A new reaction pathway for the synthesis of a [(2)H]-labelled trichloroacetimidate precursor for the preparation of glucuronides is described. Therewith, stable isotope-labelled drug glucuronides become accessible on a preparative scale, which can fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfd3d15fa85296a371d50ac881eedcb0
https://doi.org/10.1002/jlcr.3243
https://doi.org/10.1002/jlcr.3243
Autor:
Katrin Schöneweis, Matthias Schwab, A. Alexandrov, Thomas E. Mürdter, Ute Hofmann, Mathias Haag, Pavel O. Bogomolov, Stephan Urban, Antje Blank, Georg Heinkele, H. Wedemeyer, Walter-Emil Haefeli
Publikováno v:
Journal of Hepatology. 68:S522-S523
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ab7ba6a9798afbb9e5ee5931f2ac171
https://doi.org/10.1016/s0168-8278(18)31293-5
https://doi.org/10.1016/s0168-8278(18)31293-5
Autor:
Matthias Schwab, Stefan Winter, Peter A. Fasching, Georg Heinkele, Hiltrud Brauch, Thomas E. Mürdter, L Bacchus‐Gerybadze, Werner Schroth, W. Simon, Tanja Fehm, Michel Eichelbaum
Publikováno v:
Clinical Pharmacology & Therapeutics. 89:708-717
The therapeutic effect of tamoxifen depends on active metabolites, e.g., cytochrome P450 2D6 (CYP2D6) mediated formation of endoxifen. To test for additional relationships, 236 breast cancer patients were genotyped for CYP2D6, CYP2C9, CYP2B6, CYP2C19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08057486b74af3ba45820042cacda1e
https://doi.org/10.1038/clpt.2011.27
https://doi.org/10.1038/clpt.2011.27
Fate of the Antibiotic Sulfamethoxazole and Its Two Major Human Metabolites in a Water Sediment Test
Publikováno v:
Environmental Science & Technology. 43:3135-3141
Sulfonamide antibiotics are widely used in human and veterinary medicine. After their application, they are excreted in unchanged as well as in metabolized form. Due to incomplete elimination in wastewater treatment plants, they can be emitted into s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04dc5981748afe1d2458e3345c6cdc8
https://doi.org/10.1021/es900300u
https://doi.org/10.1021/es900300u
Autor:
Georg Heinkele, Thomas E. Mürdter
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:656-659
Sulfamethoxazole was labelled at positions 3, 5, and 4′ by H/D exchange in a mixture of 5% 2H2SO4 and 95% 2H2O (v/v) under reflux for 72h with good isotope incorporation and acceptable yield. Subsequently, [2H3]-sulfamethoxazole-N1-glucuronide and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77bfe3d46432c8773d90dc43c173749b
https://doi.org/10.1002/jlcr.1375
https://doi.org/10.1002/jlcr.1375
Autor:
Martin F. Fromm, Georg Heinkele, Nicolas Simon, Ute Hofmann, Céline Verstuyft, Hartmut Glaeser, Monika Hitzl, Siegfried Drescher, Christian Schaefer, Thomas E. Mürdter, Oliver Burk, Michel Eichelbaum, Laurent Becquemont
Publikováno v:
Clinical Pharmacology & Therapeutics. 79:449-460
Background and Objective On the basis of in vitro studies indicating that ursodeoxycholic acid (UDCA) is a cytochrome P450 (CYP) 3A4 inducer and a pregnane X receptor activator and because the pregnane X receptor is a transcriptional regulator of mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd638350525f5dd52169ddb3cf594f81
https://doi.org/10.1016/j.clpt.2006.01.005
https://doi.org/10.1016/j.clpt.2006.01.005