Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Georg Halder"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Hyperactivation of YAP/TAZ, the Hippo pathway downstream effectors, is common in human cancer. The requirement of YAP/TAZ for cancer cell survival in preclinical models, prompted the development of pharmacological inhibitors that suppress th
Externí odkaz:
https://doaj.org/article/81918d5ba10342318d2b7e11ec28ad7f
Autor:
Swann Floc'hlay, Ramya Balaji, Dimitrije Stanković, Valerie M Christiaens, Carmen Bravo González-Blas, Seppe De Winter, Gert J Hulselmans, Maxime De Waegeneer, Xiaojiang Quan, Duygu Koldere, Mardelle Atkins, Georg Halder, Mirka Uhlirova, Anne-Kathrin Classen, Stein Aerts
Publikováno v:
eLife, Vol 12 (2023)
Wound response programs are often activated during neoplastic growth in tumors. In both wound repair and tumor growth, cells respond to acute stress and balance the activation of multiple programs, including apoptosis, proliferation, and cell migrati
Externí odkaz:
https://doaj.org/article/466fad16d6af41f0a02156a24ebcaa84
Autor:
Vincent De Smet, Nathalie Eysackers, Vincent Merens, Mina Kazemzadeh Dastjerd, Georg Halder, Stefaan Verhulst, Inge Mannaerts, Leo A. van Grunsven
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-10 (2021)
Abstract Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently, HSC-based therapeutic candidates largely focus o
Externí odkaz:
https://doaj.org/article/8ea65b2a9036464990e291a1c81feff9
Autor:
Carmen Vicente, Rocco Stirparo, Sofie Demeyer, Charles E. de Bock, Olga Gielen, Mardelle Atkins, Jiekun Yan, Georg Halder, Bassem A. Hassan, Jan Cools
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-16 (2018)
Abstract Background The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in patients with T-cell acute lymphoblastic leukemia (T-ALL). Methods Here, we
Externí odkaz:
https://doaj.org/article/d2b4f3970332452b81f7d13001aa3d14
Autor:
Bram Lesaffer, Elisabeth Verboven, Leen Van Huffel, Iván M. Moya, Leo A. van Grunsven, Isabelle A. Leclercq, Frédéric P. Lemaigre, Georg Halder
Publikováno v:
Cells, Vol 8, Iss 4, p 380 (2019)
Inducible cyclization recombinase (Cre) transgenic mouse strains are powerful tools for cell lineage tracing and tissue-specific knockout experiments. However, low efficiency or leaky expression can be important pitfalls. Here, we compared the effici
Externí odkaz:
https://doaj.org/article/92621a6794e94aaf8c029bbd47c489fc
YAP and TAZ Heterogeneity in Primary Liver Cancer: An Analysis of Its Prognostic and Diagnostic Role
Autor:
Matthias Van Haele, Iván M. Moya, Ruçhan Karaman, Guy Rens, Janne Snoeck, Olivier Govaere, Frederik Nevens, Chris Verslype, Baki Topal, Diethard Monbaliu, Georg Halder, Tania Roskams
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 638 (2019)
Primary liver cancer comprises a diverse group of liver tumors. The heterogeneity of these tumors is seen as one of the obstacles to finding an effective therapy. The Hippo pathway, with its downstream transcriptional co-activator Yes-associated prot
Externí odkaz:
https://doaj.org/article/8f505ec69e11441aa97db28902c1be84
Autor:
Kristofer Davie, Jelle Jacobs, Mardelle Atkins, Delphine Potier, Valerie Christiaens, Georg Halder, Stein Aerts
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004994 (2015)
Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs). When TFs are bound to active regulatory regions, they displace canonical nucleosomes, making these regions biochemically de
Externí odkaz:
https://doaj.org/article/06c04a5555414c05a03f1378b8b54139
Autor:
Mardelle Atkins, Yuwei Jiang, Leticia Sansores-Garcia, Barbara Jusiak, Georg Halder, Graeme Mardon
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003731 (2013)
Organ development is directed by selector gene networks. Eye development in the fruit fly Drosophila melanogaster is driven by the highly conserved selector gene network referred to as the "retinal determination gene network," composed of approximate
Externí odkaz:
https://doaj.org/article/f771c912e3464b82a3325fac430245ab
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37615 (2012)
In Drosophila imaginal epithelia, cells mutant for the endocytic neoplastic tumor suppressor gene vps25 stimulate nearby untransformed cells to express Drosophila Inhibitor-of-Apoptosis-Protein-1 (DIAP-1), conferring resistance to apoptosis non-cell
Externí odkaz:
https://doaj.org/article/e25f05380edc4c4a8026f8a22e830e56
Autor:
Brian A Counterman, Felix Araujo-Perez, Heather M Hines, Simon W Baxter, Clay M Morrison, Daniel P Lindstrom, Riccardo Papa, Laura Ferguson, Mathieu Joron, Richard H Ffrench-Constant, Christopher P Smith, Dahlia M Nielsen, Rui Chen, Chris D Jiggins, Robert D Reed, Georg Halder, Jim Mallet, W Owen McMillan
Publikováno v:
PLoS Genetics, Vol 6, Iss 2, p e1000796 (2010)
Wing pattern evolution in Heliconius butterflies provides some of the most striking examples of adaptation by natural selection. The genes controlling pattern variation are classic examples of Mendelian loci of large effect, where allelic variation c
Externí odkaz:
https://doaj.org/article/a91d6ef2816e457dbb0d13c731ac4454