Výsledky vyhledávání - "Georg Haecker"

Checkpoint kinase 1 is essential for establishing fetal haematopoiesis and hematopoietic stem and progenitor cell survival

Autor: Georg Haecker, Fabian Schuler, Sehar Afreen, Andreas Villunger, Miriam Erlacher, Claudia Manzl

Checkpoint kinase 1 is critical for S-phase fidelity and preventing premature mitotic entry in the presence of DNA damage. Tumour cells have developed a strong dependence on CHK1 for survival and hence this kinase has developed into a popular drug-ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e59e929edf1f2bf06a23cd7f33ab364
https://doi.org/10.1101/413310

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Elektronická kniha

Biology of Chlamydia

Autor: Georg Häcker

The genus Chlamydia encompasses a number of species of obligate intracellular bacteria, including important human pathogens like the most common bacterial agent of sexually transmitted disease. This volume reviews current knowledge of chlamydial biol

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Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics

Autor: Jens Mayer, Melanie Niemer, Dewey G. McCafferty, Bettina Mayer, Boris Turk, Guenther Fritz, Pitter F. Huesgen, Kenneth R. Maksimchuk, Oliver Schilling, Martin L. Biniossek, Julian E. Fuchs, Georg Haecker, Lukas Mach

Publikováno v: Molecular & cellular proteomics 15(7), 2515-2524 (2016). doi:10.1074/mcp.O115.056671

We present protease specificity profiling based on quantitative proteomics in combination with proteome-derived peptide libraries. Peptide libraries are generated by endoproteolytic digestion of proteomes without chemical modification of primary amin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fdd4871c26655b160214e62361b8be3
https://hdl.handle.net/2128/18670

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NPM-ALK Induces Tumour Development in a Murine Model of Anaplastic Large Cell Lymphoma (ALCL) Independently of Bcl-3 Expression

Autor: Falco Fend, Rebekka Grundler, Georg Haecker, Christian Peschel, Charlotte Gruber, Justus Duyster

Publikováno v: Blood. 110:460-460

Anaplastic large cell lymphomas (ALCLs) define a subgroup of aggressive non-Hodgkin’s lymphomas. In 40–60% of systemic ALCLs, a t(2;5) (p23;q35) translocation is found, which generates a fusion gene between nucleophosmin (NPM) and the receptor ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d2b94a708fcf0170dfa5858139bbc64
https://doi.org/10.1182/blood.v110.11.460.460

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