Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Georg F. Beilhack"'
Autor:
Y. Hang, Elizabeth D. Mellins, Judith A. Shizuru, Georg F. Beilhack, Claudia Macaubas, Narendiran Rajasekaran, Cornelia H. Rinderknecht, Nan Wang
Publikováno v:
Clinical and Experimental Immunology. 174:27-37
Summary In BDC2·5 non-obese diabetic (BDC2·5NOD) mice, a spontaneous model of type 1 diabetes, CD4+ T cells express a transgene-encoded T cell receptor (TCR) with reactivity against a pancreatic antigen, chromogranin. This leads to massive infiltra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3473adfc39c36ef0e21049565d9609
https://doi.org/10.1111/cei.12163
https://doi.org/10.1111/cei.12163
Autor:
Judith A. Shizuru, Georg F. Beilhack, Rodolfo José Chaparro, Yueh-hsiu Chien, Hugh O. McDevitt, Yves Konigshofer
Publikováno v:
Proceedings of the National Academy of Sciences. 103:12475-12480
Before the onset of autoimmune destruction, type 1 diabetic patients and an animal model, the nonobese diabetic (NOD) mouse, show morphological and functional abnormalities in target organs, which may act as inciting events for leukocyte infiltration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f50d058f058290c11f20ee0ed467661
https://doi.org/10.1073/pnas.0604317103
https://doi.org/10.1073/pnas.0604317103
Autor:
Sara A. Michie, Shannon J. Turley, Baohui Xu, Georg F. Beilhack, Hugh O. McDevitt, Li-Fen Lee, Tibor Warganich
Publikováno v:
Proceedings of the National Academy of Sciences. 102:15995-16000
TNF-α has been linked to the development of type 1 diabetes (T1D). We previously reported that neonatal treatment of nonobese diabetic (NOD) mice with TNF-α accelerated the onset of T1D, whereas TNF-α blockade in the same time period resulted in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f0dcf242bcc7676c1af0462c39e6f3
https://doi.org/10.1073/pnas.0508122102
https://doi.org/10.1073/pnas.0508122102
Autor:
Yu-An Cao, Robert S. Negrin, Enosh M. Baker, Edward I. Herman, Christopher H. Contag, Andreas Beilhack, Stephan Schulz, C.B. Wieland, Jeanette Baker, Georg F. Beilhack
Publikováno v:
Blood. 106:1113-1122
Graft-versus-host disease (GVHD) is a major obstacle in allogeneic hematopoietic cell transplantation. Given the dynamic changes in immune cell subsets and tissue organization, which occur in GVHD, localization and timing of critical immunological ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6bc37762929bc844a9ae9aafa26b26
https://doi.org/10.1182/blood-2005-02-0509
https://doi.org/10.1182/blood-2005-02-0509
Publikováno v:
Diabetes. 54:1770-1779
Progression to hyperglycemia in young nonobese diabetic (NOD) mice is blocked by the transplantation of hematopoietic cells mismatched at the major histocompatibility complex (MHC). Because the NOD MHC class II allele, I-Ag7, is the primary disease s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f064c9d55386bb682754b855ced756
https://doi.org/10.2337/diabetes.54.6.1770
https://doi.org/10.2337/diabetes.54.6.1770
Autor:
Susan S. Prohaska, David C. Scherer, Georg F. Beilhack, Irving L. Weissman, Amy J. Wagers, Motonari Kondo, Markus G. Manz, Judith A. Shizuru
Publikováno v:
Annual Review of Immunology. 21:759-806
▪ Abstract Stem cell biology is scientifically, clinically, and politically a current topic. The hematopoietic stem cell, the common ancestor of all types of blood cells, is one of the best-characterized stem cells in the body and the only stem cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7566904db949a4fb0bd84213c6e1a4b9
https://doi.org/10.1146/annurev.immunol.21.120601.141007
https://doi.org/10.1146/annurev.immunol.21.120601.141007
Autor:
Tor B. Stuge, Brian Armstrong, Peter P. Lee, Emily S. Andersen, John P. Murad, Brile Chung, Jeffrey S. Weber, Georg F. Beilhack
Publikováno v:
Cell Reports, Vol 8, Iss 3, Pp 871-882 (2014)
SummaryCurrent vaccine conditions predominantly elicit low-avidity cytotoxic T lymphocytes (CTLs), which are non-tumor-cytolytic but indistinguishable by tetramer staining or enzyme-linked immunospot from high-avidity CTLs. Using CTL clones of high o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66c8eb4dbaf4f9ecb51e0e02a6be540
https://pubmed.ncbi.nlm.nih.gov/25088413
https://pubmed.ncbi.nlm.nih.gov/25088413
Autor:
Judith A. Shizuru, Cornelia H. Rinderknecht, Nan Wang, Elizabeth D. Mellins, Claudia Macaubas, Georg F. Beilhack, Phi Truong, Narendiran Rajasekaran
Publikováno v:
Arthritis and rheumatism. 65(3)
Objective In the K/BxN mouse model of inflammatory arthritis, T cells carrying a transgenic T cell receptor initiate disease by helping B cells to produce arthritogenic anti–glucose-6-phosphate isomerase (anti-GPI) autoantibodies. We found that let
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f628858420462bff70f3208c3003f970
https://pubmed.ncbi.nlm.nih.gov/23233229
https://pubmed.ncbi.nlm.nih.gov/23233229
Autor:
Gilad Landan, Jeanette Baker, Eugene C. Butcher, Ryosei Nishimura, Christopher H. Contag, Georg F. Beilhack, Enosh M. Baker, Andreas Beilhack, Edward I. Herman, Stephan Schulz, Robert S. Negrin
Publikováno v:
Blood. 111(5)
In acute graft-versus-host disease (aGVHD), donor T cells attack the recipient's gastrointestinal tract, liver, and skin. We hypothesized that blocking access to distinct lymphoid priming sites may alter the specific organ tropism and prevent aGVHD d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c28b3a6e4d433e4106b99ccaa7b096
https://pubmed.ncbi.nlm.nih.gov/17989315
https://pubmed.ncbi.nlm.nih.gov/17989315
Autor:
Robert S. Negrin, Ryosei Nishimura, Enosh M. Baker, Christopher H. Contag, Andreas Beilhack, Georg F. Beilhack, Eugene C. Butcher, Jeanette Baker, Gilad Landan, Stephan Schulz, Edward I. Herman
Publikováno v:
Biology of Blood and Marrow Transplantation. 12(2)
Acute graft-versus-host disease (aGVHD) results from alloreactive donor derived T cells attacking targets in the gastrointestinal tract, liver and skin. We observed the initiation and rapid kinetics of aGVHD in a murine model [FVB/N (H-2q) into irrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4617390d779c771d8b484adc491aa2a9