Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Georg A Hollander"'
Autor:
Heather E Stefanski, Yan Xing, Jemma Nicholls, Leslie Jonart, Emily Goren, Patricia A Taylor, Alea A Mills, Megan Riddle, John McGrath, Jakub Tolar, Georg A Hollander, Bruce R Blazar
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0261770 (2022)
Progressive immune deficiency of aging is characterized by severe thymic atrophy, contracted T cell repertoire, and poor immune function. p63 is critical for the proliferative potential of embryonic and adult stem cells, as well as thymic epithelial
Externí odkaz:
https://doaj.org/article/af94951caa154d9f82419de6d5c1d623
Autor:
Heather E Stefanski, Yan Xing, Patricia A Taylor, Stefano Maio, Jorge Henao-Meija, Adam Williams, Richard A Flavell, Georg A Hollander, Bruce R Blazar
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198871 (2018)
MicroRNAs (miRNAs) have been shown to be key modulators of post-transcriptional gene silencing in many cellular processes. In previous studies designed to understand the role of miRNAs in thymic development, we globally deleted miRNA exclusively in t
Externí odkaz:
https://doaj.org/article/7de7bba981144c9ab0dfb029f8947626
Autor:
Rumi Satoh, Kiyokazu Kakugawa, Takuwa Yasuda, Hisahiro Yoshida, Maria Sibilia, Yoshimoto Katsura, Ben Levi, Jakub Abramson, Yoko Koseki, Haruhiko Koseki, Willem van Ewijk, Georg A Hollander, Hiroshi Kawamoto
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005776 (2016)
Thymic medullary regions are formed in neonatal mice as islet-like structures, which increase in size over time and eventually fuse a few weeks after birth into a continuous structure. The development of medullary thymic epithelial cells (TEC) is dep
Externí odkaz:
https://doaj.org/article/25c10f01c498447a99c4308b6a476f54
Autor:
Alexandria C. Wells, Kaito A. Hioki, Constance C. Angelou, Adam C. Lynch, Xueting Liang, Daniel J. Ryan, Iris Thesmar, Saule Zhanybekova, Saulius Zuklys, Jacob Ullom, Agnes Cheong, Jesse Mager, Georg A. Hollander, Elena L. Pobezinskaya, Leonid A. Pobezinsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The success of the CD8 T cell-mediated immune response against infections and tumors depends on the formation of a long-lived memory pool, and the protection of effector cells from exhaustion. The advent of checkpoint blockade therapy has si
Externí odkaz:
https://doaj.org/article/91894239e4cb479a9f76d823674243ce
Autor:
Beth Lucas, Andrea J. White, Fabian Klein, Clara Veiga-Villauriz, Adam Handel, Andrea Bacon, Emilie J. Cosway, Kieran D. James, Sonia M. Parnell, Izumi Ohigashi, Yousuke Takahama, William E. Jenkinson, Georg A. Hollander, Wei-Yu Lu, Graham Anderson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The thymus medulla is a key site for immunoregulation and tolerance, and its functional specialisation is achieved through the complexity of medullary thymic epithelial cells (mTEC). While the importance of the medulla for thymus function is
Externí odkaz:
https://doaj.org/article/2a0c9868ae7e45eaa4dd7a3a89e0aac1
Autor:
Abdulvasey Mohammed, Benjamin D. Solomon, Priscila F. Slepicka, Kelsea M. Hubka, Hanh Dan Nguyen, Michael G. Chavez, Christine Y. Yeh, Doo Kyung Kim, Vittorio Sebastiano, Kenneth I Weinberg, Virginia Winn, Casey A. Gifford, Veronika Kedlian, Jong-Eun Park, Georg A. Hollander, Purvesh Khatri, Sarah A. Teichmann, Andrew J. Gentles, Katja G. Weinacht
The thymus is essential in directing T cell immunity and central tolerance, yet the signals that drive thymic ontogeny beyond the anterior foregut remain incompletely understood. Here we elucidate key pathways instructing commitment and specializatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dbf17997206a7cd63c10e68263f9eaa
https://doi.org/10.1101/2022.10.02.510339
https://doi.org/10.1101/2022.10.02.510339
Autor:
Ryan Kelly, Emily Goren, Patricia Taylor, Hamish S Scott, Elena Komarova, Andrei Gudkov, Georg A. Hollander, Bruce R. Blazar
Publikováno v:
Blood. 114:4485-4485
Abstract 4485 Myeloablative conditioning prior to bone marrow transplantation (BMT) results in thymic epithelial cell (TEC) injury, T cell immune deficiency, and susceptibility to opportunistic infections. Conditioning regimen-induced TEC damage dire
Autor:
S. Rhiannon Jenkinson, Saulius Zuklys, Georg A Hollander, Pandelakis A Koni, Boris Reizis, Richard J Hodes
Publikováno v:
The Journal of Immunology. 182:138.28-138.28
Development of T cells from T cell precursors occurs in the thymus through interactions of T lineage cells with thymic stromal populations. These stromal populations are distributed in an ordered fashion that defines thymic architecture and provides
Autor:
Jeanette Baran-Gale, Michael D Morgan, Stefano Maio, Fatima Dhalla, Irene Calvo-Asensio, Mary E Deadman, Adam E Handel, Ashley Maynard, Steven Chen, Foad Green, Rene V Sit, Norma F Neff, Spyros Darmanis, Weilun Tan, Andy P May, John C Marioni, Chris P Ponting, Georg A Holländer
Publikováno v:
eLife, Vol 9 (2020)
Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the mol
Externí odkaz:
https://doaj.org/article/0801b66fbced40e4a16cb9a6776b1379
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12766 (2010)
Thymopoiesis requires thymocyte-stroma interactions and proteases that promote cell migration by degrading extracellular matrix and releasing essential cytokines and chemokines. A role for several members of the A Disintegrin and Metalloprotease (ADA
Externí odkaz:
https://doaj.org/article/e5ef65c9a1df474e9bfa2b13933af232