Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Georg A Holländer"'
Autor:
Jeanette Baran-Gale, Michael D Morgan, Stefano Maio, Fatima Dhalla, Irene Calvo-Asensio, Mary E Deadman, Adam E Handel, Ashley Maynard, Steven Chen, Foad Green, Rene V Sit, Norma F Neff, Spyros Darmanis, Weilun Tan, Andy P May, John C Marioni, Chris P Ponting, Georg A Holländer
Publikováno v:
eLife, Vol 9 (2020)
Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the mol
Externí odkaz:
https://doaj.org/article/0801b66fbced40e4a16cb9a6776b1379
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12766 (2010)
Thymopoiesis requires thymocyte-stroma interactions and proteases that promote cell migration by degrading extracellular matrix and releasing essential cytokines and chemokines. A role for several members of the A Disintegrin and Metalloprotease (ADA
Externí odkaz:
https://doaj.org/article/e5ef65c9a1df474e9bfa2b13933af232
Autor:
Elisabeth Fayard, Jason Gill, Magdalena Paolino, Debby Hynx, Georg A Holländer, Brian A Hemmings
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e992 (2007)
The thymus constitutes the primary lymphoid organ for the majority of T cells. The phosphatidyl-inositol 3 kinase (PI3K) signaling pathway is involved in lymphoid development. Defects in single components of this pathway prevent thymocytes from progr
Externí odkaz:
https://doaj.org/article/3dc544cb0930423a9ba6de98559c1531
Autor:
Fabian Klein, Clara Veiga-Villauriz, Anastasiya Börsch, Stefano Maio, Sam Palmer, Fatima Dhalla, Adam E. Handel, Saulius Zuklys, Irene Calvo-Asensio, Lucas Musette, Mary E. Deadman, Andrea J. White, Beth Lucas, Graham Anderson, Georg A. Holländer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The network of thymic stromal cells provides essential niches with unique molecular cues controlling T cell development and selection. Recent single-cell RNA sequencing studies have uncovered previously unappreciated transcriptional heteroge
Externí odkaz:
https://doaj.org/article/58106d4dcccf4fdebf3a90d5d836fcdb
Autor:
Loredana Ruggeri, Elena Urbani, Davide Chiasserini, Federica Susta, Pier Luigi Orvietani, Emanuela Burchielli, Sara Ciardelli, Rosaria Sola, Stefano Bruscoli, Antonella Cardinale, Antonio Pierini, Sander R. Piersma, Stefano Pasquino, Franco Locatelli, Dunia Ramarli, Enrico Velardi, Luciano Binaglia, Connie R. Jimenez, Georg A. Holländer, Andrea Velardi
Publikováno v:
Blood, 140(22), 2323-2334. American Society of Hematology
Ruggeri, L, Urbani, E, Chiasserini, D, Susta, F, Orvietani, P L, Burchielli, E, Ciardelli, S, Sola, R, Bruscoli, S, Cardinale, A, Pierini, A, Piersma, S R, Pasquino, S, Locatelli, F, Ramarli, D, Velardi, E, Binaglia, L, Jimenez, C R, Holländer, G A & Velardi, A 2022, ' Donor natural killer cells trigger production of β-2-microglobulin to enhance post–bone marrow transplant immunity ', Blood, vol. 140, no. 22, pp. 2323-2334 . https://doi.org/10.1182/blood.2021015297
Ruggeri, L, Urbani, E, Chiasserini, D, Susta, F, Orvietani, P L, Burchielli, E, Ciardelli, S, Sola, R, Bruscoli, S, Cardinale, A, Pierini, A, Piersma, S R, Pasquino, S, Locatelli, F, Ramarli, D, Velardi, E, Binaglia, L, Jimenez, C R, Holländer, G A & Velardi, A 2022, ' Donor natural killer cells trigger production of β-2-microglobulin to enhance post–bone marrow transplant immunity ', Blood, vol. 140, no. 22, pp. 2323-2334 . https://doi.org/10.1182/blood.2021015297
Allogeneic hematopoietic transplantation is a powerful treatment for hematologic malignancies. Posttransplant immune incompetence exposes patients to disease relapse and infections. We previously demonstrated that donor alloreactive natural killer (N
Autor:
Angela R. Smith, Ioanna A. Rota, Stefano Maio, Michel J. Massaad, Troy C. Lund, Luigi D. Notarangelo, Georg A. Holländer, Bruce R. Blazar
Publikováno v:
Blood Advances, Vol 1, Iss 23, Pp 2083-2087 (2017)
Externí odkaz:
https://doaj.org/article/aa470d0df7d84daa9a6b15b8d6f8162e
Autor:
Moustafa Attar, Stephen N. Sansom, David Buck, Kathrin Jansen, Maria Lopopolo, Georg A. Holländer, Stefano Maio, Noriko Shikama-Dorn
Publikováno v:
Genome Res
Genome Research, 31 (11)
Genome Research, 31 (11)
Thymic epithelial cells (TEC) control the selection of a T cell repertoire reactive to pathogens but tolerant of self. This process is known to involve the promiscuous expression of virtually the entire protein-coding gene repertoire, but the extent
Autor:
Guangwei Cui, Akihiro Shimba, Jianshi Jin, Taisaku Ogawa, Yukiko Muramoto, Hitoshi Miyachi, Shinya Abe, Takuma Asahi, Shizue Tani-ichi, Johannes M. Dijkstra, Yayoi Iwamoto, Kirill Kryukov, Yuanbo Zhu, Daichi Takami, Takahiro Hara, Satsuki Kitano, Yan Xu, Hajime Morita, Moyu Zhang, Lynn Zreka, Keishi Miyata, Takashi Kanaya, Shinya Okumura, Takashi Ito, Etsuro Hatano, Yoshimasa Takahashi, Hiroshi Watarai, Yuichi Oike, Tadashi Imanishi, Hiroshi Ohno, Toshiaki Ohteki, Nagahiro Minato, Masato Kubo, Georg A. Holländer, Hideki Ueno, Takeshi Noda, Katsuyuki Shiroguchi, Koichi Ikuta
Publikováno v:
Science Immunology. 7
Invariant natural killer T (iNKT) cells are a group of innate-like T lymphocytes that recognize lipid antigens. They are supposed to be tissue resident and important for systemic and local immune regulation. To investigate the heterogeneity of iNKT c
Autor:
Muge Sayitoglu, Raif S. Geha, Luca Maragliano, Carla Borzacchiello, A Worth, Ghassan Dbaibo, Moaffaq Mahdi, Bénédicte Neven, Peter Ciznar, Ioanna A. Rota, Ana E. Sousa, José Gonçalo Marques, Akella Radha Rama Devi, Emilia Cirillo, Rima Hanna-Wakim, E. Graham Davies, Giuliana Giardino, Alexandra Y. Kreins, Janet Chou, Sule Haskologlu, Georg A. Holländer, Fabio Benfenati, Candan Islamoglu, Figen Dogu, Fatima Dhalla, Claudio Pignata, Sinem Firtina, Aydan Ikinciogullari, Svetlana O. Sharapova
Publikováno v:
Journal of Clinical Immunology
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
© The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriat
Autor:
Angeline E Gavard, Adam E. Handel, J.A. Newman, Hazel Aitkenhead, Georg A. Holländer, Opher Gileadi, Ioanna A. Rota
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry, 295 (10)
Journal of Biological Chemistry, 295 (10)
Forkhead box N1 (FOXN1) is a member of the forkhead box family of transcription factors and plays an important role in thymic epithelial cell differentiation and development. FOXN1 mutations in humans and mice give rise to the “nude” phenotype, w