Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Georg A Holländer"'
Autor:
Fabian Klein, Clara Veiga-Villauriz, Anastasiya Börsch, Stefano Maio, Sam Palmer, Fatima Dhalla, Adam E. Handel, Saulius Zuklys, Irene Calvo-Asensio, Lucas Musette, Mary E. Deadman, Andrea J. White, Beth Lucas, Graham Anderson, Georg A. Holländer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The network of thymic stromal cells provides essential niches with unique molecular cues controlling T cell development and selection. Recent single-cell RNA sequencing studies have uncovered previously unappreciated transcriptional heteroge
Externí odkaz:
https://doaj.org/article/58106d4dcccf4fdebf3a90d5d836fcdb
Autor:
Bergithe E. Oftedal, Stefano Maio, Adam E. Handel, Madeleine P. J. White, Duncan Howie, Simon Davis, Nicolas Prevot, Ioanna A. Rota, Mary E. Deadman, Benedikt M. Kessler, Roman Fischer, Nikolaus S. Trede, Erdinc Sezgin, Rick M. Maizels, Georg A. Holländer
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Oftedal et al. generate mice lacking the chaperonin subunit CCT8 in T cells. They find that loss of CCT8 leads to reduced formation of nuclear actin filaments, changes in proteostasis, defective Th2 cell polarization and T cell metabolism and a faile
Externí odkaz:
https://doaj.org/article/f3b7f22ef77541f089085a26cdea4934
Autor:
Thomas Barthlott, Adam E. Handel, Hong Ying Teh, Rushika C. Wirasinha, Katrin Hafen, Saulius Žuklys, Benoit Roch, Stuart H. Orkin, Jean-Pierre de Villartay, Stephen R. Daley, Georg A. Holländer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Development of the T cells requires functions from thymic epithelial cells, whose development and function are epigenetically regulated. Here the authors show that inactivation of the polycomb repressive complex 2 (PRC2) alters the H3K27me3 configura
Externí odkaz:
https://doaj.org/article/bea5fbe30e2340e383f4864410b7a2fd
Autor:
Loredana Ruggeri, Elena Urbani, Davide Chiasserini, Federica Susta, Pier Luigi Orvietani, Emanuela Burchielli, Sara Ciardelli, Rosaria Sola, Stefano Bruscoli, Antonella Cardinale, Antonio Pierini, Sander R. Piersma, Stefano Pasquino, Franco Locatelli, Dunia Ramarli, Enrico Velardi, Luciano Binaglia, Connie R. Jimenez, Georg A. Holländer, Andrea Velardi
Publikováno v:
Blood, 140(22), 2323-2334. American Society of Hematology
Ruggeri, L, Urbani, E, Chiasserini, D, Susta, F, Orvietani, P L, Burchielli, E, Ciardelli, S, Sola, R, Bruscoli, S, Cardinale, A, Pierini, A, Piersma, S R, Pasquino, S, Locatelli, F, Ramarli, D, Velardi, E, Binaglia, L, Jimenez, C R, Holländer, G A & Velardi, A 2022, ' Donor natural killer cells trigger production of β-2-microglobulin to enhance post–bone marrow transplant immunity ', Blood, vol. 140, no. 22, pp. 2323-2334 . https://doi.org/10.1182/blood.2021015297
Ruggeri, L, Urbani, E, Chiasserini, D, Susta, F, Orvietani, P L, Burchielli, E, Ciardelli, S, Sola, R, Bruscoli, S, Cardinale, A, Pierini, A, Piersma, S R, Pasquino, S, Locatelli, F, Ramarli, D, Velardi, E, Binaglia, L, Jimenez, C R, Holländer, G A & Velardi, A 2022, ' Donor natural killer cells trigger production of β-2-microglobulin to enhance post–bone marrow transplant immunity ', Blood, vol. 140, no. 22, pp. 2323-2334 . https://doi.org/10.1182/blood.2021015297
Allogeneic hematopoietic transplantation is a powerful treatment for hematologic malignancies. Posttransplant immune incompetence exposes patients to disease relapse and infections. We previously demonstrated that donor alloreactive natural killer (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5d79aebd2e710cbd7d981957024c0f
https://doi.org/10.1182/blood.2021015297
https://doi.org/10.1182/blood.2021015297
Autor:
Jeanette Baran-Gale, Michael D Morgan, Stefano Maio, Fatima Dhalla, Irene Calvo-Asensio, Mary E Deadman, Adam E Handel, Ashley Maynard, Steven Chen, Foad Green, Rene V Sit, Norma F Neff, Spyros Darmanis, Weilun Tan, Andy P May, John C Marioni, Chris P Ponting, Georg A Holländer
Publikováno v:
eLife, Vol 9 (2020)
Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the mol
Externí odkaz:
https://doaj.org/article/0801b66fbced40e4a16cb9a6776b1379
Autor:
Qianxin Wu, Quentin R. V. Ferry, Toni A. Baeumler, Yale S. Michaels, Dimitrios M. Vitsios, Omer Habib, Roland Arnold, Xiaowei Jiang, Stefano Maio, Bruno R. Steinkraus, Marta Tapia, Paolo Piazza, Ni Xu, Georg A. Holländer, Thomas A. Milne, Jin-Soo Kim, Anton J. Enright, Andrew R. Bassett, Tudor A. Fulga
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
RNA regulatory elements (RREs) are important post-transcriptional control features but studying them requires disrupting their activity without disturbing cellular homeostasis. Here the authors present GenERA, a CRISPR-Cas9 screening platform of in s
Externí odkaz:
https://doaj.org/article/db4eb21f42e2466d9fc7c9b4e4aa2f37
Autor:
Angela R. Smith, Ioanna A. Rota, Stefano Maio, Michel J. Massaad, Troy C. Lund, Luigi D. Notarangelo, Georg A. Holländer, Bruce R. Blazar
Publikováno v:
Blood Advances, Vol 1, Iss 23, Pp 2083-2087 (2017)
Externí odkaz:
https://doaj.org/article/aa470d0df7d84daa9a6b15b8d6f8162e
Autor:
Joannah R. Fergusson, Michael D. Morgan, Melanie Bruchard, Leonie Huitema, Balthasar A. Heesters, Vincent van Unen, Jan Piet van Hamburg, Nicole N. van der Wel, Daisy Picavet, Frits Koning, Sander W. Tas, Mark S. Anderson, John C. Marioni, Georg A. Holländer, Hergen Spits
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Expression of the Autoimmune regulator (AIRE) outside of the thymus has long been suggested in both humans and mice, but the cellular source in humans has remained undefined. Here we identify AIRE expression in human tonsils and extensively analyzed
Externí odkaz:
https://doaj.org/article/5a82ce720c14415a91015c3f54818c7a
Autor:
Adam E. Handel, Noriko Shikama-Dorn, Saule Zhanybekova, Stefano Maio, Annina N. Graedel, Saulius Zuklys, Chris P. Ponting, Georg A. Holländer
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Thymic epithelial cells (TEC) effect crucial roles in thymopoiesis including the control of negative thymocyte selection. This process depends on their capacity to express promiscuously genes encoding tissue-restricted antigens. This competence is ac
Externí odkaz:
https://doaj.org/article/60171e438a3e41e1b78f9e333d9ba87b
Autor:
Moustafa Attar, Stephen N. Sansom, David Buck, Kathrin Jansen, Maria Lopopolo, Georg A. Holländer, Stefano Maio, Noriko Shikama-Dorn
Publikováno v:
Genome Res
Genome Research, 31 (11)
Genome Research, 31 (11)
Thymic epithelial cells (TEC) control the selection of a T cell repertoire reactive to pathogens but tolerant of self. This process is known to involve the promiscuous expression of virtually the entire protein-coding gene repertoire, but the extent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a46136aa97aad671b1982ba0d683f7
https://doi.org/10.1101/gr.275245.121
https://doi.org/10.1101/gr.275245.121