Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Georg, Vogler"'
Autor:
Cristiana Dondi, Georg Vogler, Anjali Gupta, Stanley M. Walls, Anaïs Kervadec, James Marchant, Michaela R. Romero, Soda Diop, Jason Goode, John B. Thomas, Alex R. Colas, Rolf Bodmer, Marc Montminy, Karen Ocorr
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114549- (2024)
Summary: CREB-regulated transcription co-activator (CRTC) is activated by Calcineurin (CaN) to regulate gluconeogenic genes. CaN also has roles in cardiac hypertrophy. Here, we explore a cardiac-autonomous role for CRTC in cardiac hypertrophy. In Dro
Externí odkaz:
https://doaj.org/article/c996134180b94600beaae178614fec84
Autor:
Katja Birker, Shuchao Ge, Natalie J Kirkland, Jeanne L Theis, James Marchant, Zachary C Fogarty, Maria A Missinato, Sreehari Kalvakuri, Paul Grossfeld, Adam J Engler, Karen Ocorr, Timothy J Nelson, Alexandre R Colas, Timothy M Olson, Georg Vogler, Rolf Bodmer
Publikováno v:
eLife, Vol 12 (2023)
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited. We performed whole genome seq
Externí odkaz:
https://doaj.org/article/295c6b7f92104c7bb7e08f101b5ff3af
Autor:
Saswati Saha, Lionel Spinelli, Jaime A Castro Mondragon, Anaïs Kervadec, Michaela Lynott, Laurent Kremmer, Laurence Roder, Sallouha Krifa, Magali Torres, Christine Brun, Georg Vogler, Rolf Bodmer, Alexandre R Colas, Karen Ocorr, Laurent Perrin
Publikováno v:
eLife, Vol 11 (2022)
Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlying complexity is a major hurdle. We investigated the natural variation of cardiac performance in the sequenced inbred lines of the Drosophi
Externí odkaz:
https://doaj.org/article/35f1c5c43e764e80af9403e2933094a5
Autor:
Analyne M Schroeder, Tanja Nielsen, Michaela Lynott, Georg Vogler, Alexandre R Colas, Rolf Bodmer
Publikováno v:
PLoS Genetics, Vol 18, Iss 10, p e1010448 (2022)
Establishing a catalog of Congenital Heart Disease (CHD) genes and identifying functional networks would improve our understanding of its oligogenic underpinnings. Our studies identified protein biogenesis cofactors Nascent polypeptide-Associated Com
Externí odkaz:
https://doaj.org/article/d1dece93db3b499cad8f2aa82f483b61
Autor:
Elia Smeir, Sarah Leberer, Annelie Blumrich, Georg Vogler, Anastasia Vasiliades, Sandra Dresen, Carsten Jaeger, Yoann Gloaguen, Christian Klose, Dieter Beule, P. Christian Schulze, Rolf Bodmer, Anna Foryst-Ludwig, Ulrich Kintscher
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103314- (2021)
Summary: Cardiolipin (CL) is a major cardiac mitochondrial phospholipid maintaining regular mitochondrial morphology and function in cardiomyocytes. Cardiac CL production includes its biosynthesis and a CL remodeling process. Here we studied the impa
Externí odkaz:
https://doaj.org/article/495faf1d987c41ec8b93ea96ff9681f2
Autor:
Annelie Blumrich, Georg Vogler, Sandra Dresen, Soda Balla Diop, Carsten Jaeger, Sarah Leberer, Jana Grune, Eva K. Wirth, Beata Hoeft, Kostja Renko, Anna Foryst-Ludwig, Joachim Spranger, Stephan Sigrist, Rolf Bodmer, Ulrich Kintscher
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102288- (2021)
Summary: The cross talk between adipose tissue and the heart has an increasing importance for cardiac function under physiological and pathological conditions. This study characterizes the role of fat body lipolysis for cardiac function in Drosophila
Externí odkaz:
https://doaj.org/article/44d9abc00f5c4236a1b2cc5ddfbcc027
Autor:
Emilie Auxerre-Plantié, Tanja Nielsen, Marcel Grunert, Olga Olejniczak, Andreas Perrot, Cemil Özcelik, Dennis Harries, Faramarz Matinmehr, Cristobal Dos Remedios, Christian Mühlfeld, Theresia Kraft, Rolf Bodmer, Georg Vogler, Silke R. Sperling
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 12 (2020)
The causal genetic underpinnings of congenital heart diseases, which are often complex and multigenic, are still far from understood. Moreover, there are also predominantly monogenic heart defects, such as cardiomyopathies, with known disease genes f
Externí odkaz:
https://doaj.org/article/3ad5653fc6794cb9940a877a8adecd22
Autor:
Jeanne L Theis, Georg Vogler, Maria A Missinato, Xing Li, Tanja Nielsen, Xin-Xin I Zeng, Almudena Martinez-Fernandez, Stanley M Walls, Anaïs Kervadec, James N Kezos, Katja Birker, Jared M Evans, Megan M O'Byrne, Zachary C Fogarty, André Terzic, Paul Grossfeld, Karen Ocorr, Timothy J Nelson, Timothy M Olson, Alexandre R Colas, Rolf Bodmer
Publikováno v:
eLife, Vol 9 (2020)
Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically complex and poorly understood. Here, a multidisciplinary platform was established to functionally evaluate novel CHD gene candidates, based on whole-g
Externí odkaz:
https://doaj.org/article/7b02a3ed48a047c4bd8549ffe623c1c1
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 7, Iss 2, p 22 (2020)
Left-sided congenital heart defects (CHDs) are among the most common forms of congenital heart disease, but a disease-causing gene has only been identified in a minority of cases. Here, we identified a candidate gene for CHDs, KIF1A, that was associa
Externí odkaz:
https://doaj.org/article/2884066d6d1f47eb9dde89a56175c542
Autor:
Georg Vogler, Rolf Bodmer
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 2, Iss 1, Pp 2-16 (2015)
Many of the major discoveries in the fields of genetics and developmental biology have been made using the fruit fly, Drosophila melanogaster. With regard to heart development, the conserved network of core cardiac transcription factors that underlie
Externí odkaz:
https://doaj.org/article/b57c7411af8c447cb230178b0e974b11