Výsledky vyhledávání - "Georg, Sager"

Akademický článek

Pharmacodynamic properties for inhibition of cAMP- and cGMP elimination by pentoxifylline remain unaltered in vitro during hypothermia

Autor: Anders Lund Selli, Adrina Kalasho Kuzmiszyn, Natalia Smaglyukova, Timofey Kondratiev, Ole-Martin Fuskevåg, Georg Sager, Erik Sveberg Dietrichs

Publikováno v: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol 30, Iss 1, Pp 1-10 (2022)

Abstract Background Rewarming from hypothermia is associated with severe complications, one of which is hypothermia-induced cardiac dysfunction. This condition is characterized by decreased cardiac output accompanied by increased total peripheral res

Externí odkaz: https://doaj.org/article/4f4d3e3c244c46e3a908d3c35c339073

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Akademický článek

Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia—Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate

Autor: Adrina Kalasho Kuzmiszyn, Anders Lund Selli, Natalia Smaglyukova, Timofei Kondratiev, Ole-Martin Fuskevåg, Roy Andre Lyså, Aina Westrheim Ravna, Torkjel Tveita, Georg Sager, Erik Sveberg Dietrichs

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Introduction: Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiovascular dysfunction, which could lead to shock. Current guidelines do not recommend any pharmacological treatment at core temperatures below 30°C,

Externí odkaz: https://doaj.org/article/218ba614aef944caa6c5b774dba33ce7

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Akademický článek

Treatment of Cardiovascular Dysfunction With PDE5-Inhibitors – Temperature Dependent Effects on Transport and Metabolism of cAMP and cGMP

Autor: Anders L. Selli, Adrina K. Kuzmiszyn, Natalia Smaglyukova, Timofei V. Kondratiev, Ole-Martin Fuskevåg, Roy A. Lyså, Aina W. Ravna, Torkjel Tveita, Georg Sager, Erik S. Dietrichs

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

IntroductionCardiovascular dysfunction is a potentially lethal complication of hypothermia. Due to a knowledge gap, pharmacological interventions are not recommended at core temperatures below 30°C. Yet, further cooling is induced in surgical proced

Externí odkaz: https://doaj.org/article/221ca9ad18974ef38a7755998301474a

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Moderate but not severe hypothermia increases intracellular cyclic AMP through preserved production and reduced elimination

Autor: Adrina Kalasho Kuzmiszyn, Anders Lund Selli, Markus Furuholmen, Natalia Smaglyukova, Timofei Kondratiev, Ole-Martin Fuskevåg, Georg Sager, Erik Sveberg Dietrichs

Publikováno v: Cryobiology. 110:18-23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::daa0c4cddb22f28351660a367696389b
https://doi.org/10.1016/j.cryobiol.2023.01.005

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Akademický článek

Data on RT-qPCR assay of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) from human uterine endometrial tissue and cancer cells of the Uterine Cervix

Autor: Natalia Smaglyukova, Elise Thoresen Sletten, Anne Ørbo, Georg Sager

Publikováno v: Data in Brief, Vol 31, Iss , Pp 105923- (2020)

A previous investigation showed that the endometrium normalized in women with endometrial hyperplasia after three months treatment with high dose levonorgestrel IUS (intrauterine system) [1]. The effect was maintained even if immunohistochemical anal

Externí odkaz: https://doaj.org/article/e2be6fa3514e4342bd580a4383231593

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Corrigendum to 'Identification and experimental confirmation of novel cGMP efflux inhibitors by virtual ligand screening of vardenafil-analogues' [Biomed. Pharmacother. 126 (2020) 110109]

Autor: Farzane Kuresh Kashgari, Aina Ravna, Georg Sager, Roy Lyså, Istvan Enyedy, Erik Sveberg Dietrichs

Publikováno v: Biomedicine & Pharmacotherapy. 152:113228

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0835394a906428073d400ffe6da16a3
https://doi.org/10.1016/j.biopha.2022.113228

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Inhibition of ABCC5-mediated cGMP transport by progesterone, testosterone and their analogues

Autor: Aina Westrheim Ravna, Sondre Ulstein Odland, Georg Sager, Erik Sveberg Dietrichs, Natalia Smaglyukova

The biodynamics and biokinetics of sex hormones are complex. In addition to the classical steroid receptors (nuclear receptors), these hormones act through several non-genomic mechanisms. Modulation of ABC-transporters by progesterone represents a no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f222463944499df04f4d813683fb0a4
https://hdl.handle.net/10037/23293

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Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding

Autor: Ole-Martin Fuskevåg, Hedvig Nordeng, Siri Amundsen, Olav Spigset, Georg Sager, Elisabet Nordmo

Publikováno v: Basic & Clinical Pharmacology & Toxicology

Clinical data on the transfer of triptans into human breast milk remain scarce. In a lactation study including 19 breastfeeding women with migraine, we examined the excretion of six different triptans into milk. Following intake of a single dose, eac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d1b48b370d999308aaa30106cf3eb5
http://hdl.handle.net/10852/87420

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Molecular modeling study of the testosterone metabolizing enzyme UDP-glucuronosyltransferase 2B17

Autor: Aina Westrheim Ravna, Georg Sager, Ingmar Trane, Erik Sveberg Dietrichs

Publikováno v: Bioorganicmedicinal chemistry. 36

The dominant sex hormone testosterone is mainly metabolized by liver enzymes belonging to the uridine-diphospho (UDP) glucuronosyltransferase (UGT) family. These enzymes are the main phase II enzymes, and they have an important role in the detoxifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c19b280bd6397fa22424f1ca4accbef
https://pubmed.ncbi.nlm.nih.gov/33691270

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