Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40

Autor: Nicol Kruska, Georg Reiser

Publikováno v: Neurobiology of Disease, Vol 43, Iss 2, Pp 465-472 (2011)

The accumulation of the two branched-chain fatty acids phytanic acid and pristanic acid is known to play an important role in several diseases with peroxisomal impairment, like Refsum disease, Zellweger syndrome and α-methylacyl-CoA racemase deficie

Externí odkaz: https://doaj.org/article/e83a8b62c67f437cb89e586a103a60fd

The Refsum disease marker phytanic acid, a branched chain fatty acid, affects Ca2+ homeostasis and mitochondria, and reduces cell viability in rat hippocampal astrocytes

Autor: Stefan Kahlert, Peter Schönfeld, Georg Reiser

Publikováno v: Neurobiology of Disease, Vol 18, Iss 1, Pp 110-118 (2005)

The saturated branched chain fatty acid, phytanic acid, a degradation product of chlorophyll, accumulates in Refsum disease, an inherited peroxisomal disorder with neurological clinical features. To elucidate the pathogenic mechanism, we investigated

Externí odkaz: https://doaj.org/article/767fde3c60574a00a9ea0b0083bae4b3

The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases

Autor: Georg Reiser, Zhihui Zhu

Publikováno v: Neurochemistry International. 115:69-79

Small heat shock proteins (sHsps) are a group of proteins with molecular mass between 12 and 43 kDa. Currently, 11 members of this family have been classified, namely HspB1 to HspB11. HspB1, HspB2, HspB5, HspB6, HspB7, and HspB8, which are expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f2522db0d13c7287bc75774abfdc56
https://doi.org/10.1016/j.neuint.2018.02.006

Neurons and astrocytes in an infantile neuroaxonal dystrophy (INAD) mouse model show characteristic alterations in glutamate-induced Ca 2+ signaling

Autor: Mikhail Strokin, Georg Reiser

Publikováno v: Neurochemistry International. 108:121-132

INAD (infantile neuroaxonal dystrophy, OMIM#256600), an autosomal recessive inherited degenerative disease, is associated with PLA2G6 mutations. PLA2G6 encodes Ca2+-independent phospholipase A2 (VIA iPLA2). However, it is unclear how the PLA2G6-mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::443c7f7ee1a4df4c2d0446896bac9468
https://doi.org/10.1016/j.neuint.2017.03.004

Contributors

Autor: Fayeza S. Ahmed, Abit Aktas, Eyad M.T. Ali, Gamze Altun, Belmira Lara da Silveira Andrade-da-Costa, Ruth H. Asch, Ricielle Lopes Augusto, Graciela Avitia, Mario Barbagallo, Olivia E. Bogucki, John William Capps, Sabrina Castellano, Carol L. Cheatham, Andrea J. Connor, Lisette C.P.G.M. de Groot, Ricardo Augusto de Melo Reis, Raphael Fabricio de Souza, Peter J. Dearborn, Ligia J. Dominguez, Andrew Elagizi, Merrill F. Elias, H.M. Francis, Hércules Rezende Freitas, Fabio Galvano, Grace E. Giles, Justyna Godos, Jacqueline F. Gould, Giuseppe Grosso, Christine Heberden, Alinny Rosendo Isaac, Hiroyasu Iso, Luigi Janiri, Corinne Joffre, Semra Kaçar, Robin B. Kanarek, Arife Ahsen Kaplan, Süleyman Kaplan, Junhwan Kim, Elfide Gizem Kıvrak, M. Yulianto Kurniawan, Cyrus E. Kuschner, Carl J. Lavie, Sophie Layé, Rafael Longhi, Yolanda Loya Méndez, Caroline R. Mahoney, Gisele Gus Manfro, Giuseppe Marano, Tomislav Mašek, Elise Maximin, Marianna Mazza, Salvatore Mazza, Robert K. McNamara, Humberto Milani, Robert R. Miller, Utako Murai, Agnès Nadjar, Daniela Velasquez Oliveira, Marissa Owen, Georg Reiser, Charlotte Rey, Veronica Portillo Reyes, Gilberto Reyes Leal, Danitsa Marcos Rodrigues, Erika Rodriguez-Guzman, Christine Scanlan, Peter Schönfeld, Kelly W. Sheppard, Patrícia Pelufo Silveira, Vikas Singh, Lisa G. Smithers, R.J. Stevenson, Vasanti Suvarna, Gianandrea Traversi, Rie Usuki, Ondine van de Rest, Kathryn VanEgmond, Jennifer L. Watts, Taylor K. Wessel, Tsukasa Yagi, Kazumasa Yamagishi, Kıymet Kübra Yurt, Charles N. Zawatsky

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d47efeeac620635c8a3fcae174e78163
https://doi.org/10.1016/b978-0-12-815238-6.09991-0