Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Georg, Pongratz"'
Autor:
Rebecca Sohn, Tina Assar, Isabelle Kaufhold, Marco Brenneis, Sebastian Braun, Marius Junker, Frank Zaucke, Georg Pongratz, Zsuzsa Jenei-Lanzl
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Osteoarthritis (OA) is a chronic degenerative joint disease causing limited mobility and pain, with no curative treatment available. Recent in vivo studies suggested autonomic alterations during OA progression in patients, yet cli
Externí odkaz:
https://doaj.org/article/3902426297cc4f8d90fc5e644e8f9e6c
Autor:
Bruno Fautrel, Peter Nash, Arthur Kavanaugh, Peter C Taylor, René Westhovens, Rieke Alten, Janet Pope, Dick de Vries, Chris Watson, Georg Pongratz, Pieter-Jan Stiers, Ken Hasegawa, Shangbang Rao
Publikováno v:
RMD Open, Vol 10, Iss 1 (2024)
Objective This post hoc analysis of the FINCH 1–3 (NCT02889796, NCT02873936 and NCT02886728) studies assessed specific effects of filgotinib on pain control and their relationship with other aspects of efficacy in patients with rheumatoid arthritis
Externí odkaz:
https://doaj.org/article/1d73e4d9b70646f5a6466193ed608507
Publikováno v:
Journal of Inflammation, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Catecholamines are major neurotransmitters of the sympathetic nervous system (SNS) and they are of pivotal importance in regulating numerous physiological and pathological processes. Rheumatoid arthritis (RA) is influenced by the
Externí odkaz:
https://doaj.org/article/f70e8e10a92c4e6a8e7b2a6c8392d999
Autor:
Nadine Honke, Torsten Lowin, Birgit Opgenoorth, Namir Shaabani, Alexander Lautwein, John R. Teijaro, Matthias Schneider, Georg Pongratz
Publikováno v:
PLoS Biology, Vol 20, Iss 1 (2022)
The sympathetic nervous system (SNS) contributes to immune balance by promoting anti-inflammatory B cells. However, whether B cells possess a self-regulating mechanism by which they modulate regulatory B cell (Breg) function is not well understood. I
Externí odkaz:
https://doaj.org/article/9a8cde83436a4dcabfaf3c891add29ec
Autor:
Julia Hesse, Magdalena Siekierka-Harreis, Bodo Steckel, Christina Alter, Merle Schallehn, Nadine Honke, Marie-Laure Schnieringer, Madita Wippich, Rebekka Braband, Matthias Schneider, Harald Surowy, Dagmar Wieczorek, Jürgen Schrader, Georg Pongratz
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103616- (2021)
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that leads to a breakdown of tolerance to self-antigens resulting in inflammation and organ damage. The anti-inflammatory activity of CD73-derived adenosine is well docume
Externí odkaz:
https://doaj.org/article/3a3c067855944da7a11f780ad0c8a810
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 1950 (2022)
The sympathetic nervous system (SNS) has either a pro-inflammatory or anti-inflammatory effect, depending on the stage of arthritis. In the past, treatment of arthritic B cells with a β2-adrenergic receptor (β2-ADR) agonist has been shown to attenu
Externí odkaz:
https://doaj.org/article/d38142b306b0418ebd8e0ec977d8d56d
Autor:
Silvia Piantoni, Francesca Regola, Stefania Masneri, Michele Merletti, Torsten Lowin, Paolo Airò, Angela Tincani, Franco Franceschini, Laura Andreoli, Georg Pongratz
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Patients with systemic lupus erythematosus (SLE) show increased serum levels of tumor necrosis factor (TNF)/TNF receptor (R) superfamily member, e.g. BAFF (B lymphocyte stimulator). Belimumab, a monoclonal antibody against soluble BAFF, i
Externí odkaz:
https://doaj.org/article/a3820d5e7a8f427ea9c50a3b3ff310c5
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1118 (2022)
δ9-Tetrahydrocannabinol (THC) has demonstrated anti-inflammatory effects in animal models of arthritis, but its mechanism of action and cellular targets are still unclear. The purpose of this study is to elucidate the effects of THC (0.1–25 µM) o
Externí odkaz:
https://doaj.org/article/bd04a7a9b83843b9b0351f7790982be6
Publikováno v:
Bio-Protocol, Vol 9, Iss 24 (2019)
In recent years, the role of sympathetic nervous fibers in chronic inflammation has become increasingly evident. At the onset of inflammation, sympathetic activity is increased in the affected tissue. However, sympathetic fibers are largely absent fr
Externí odkaz:
https://doaj.org/article/020668454e45497ba2b96950e2bef138
Autor:
Francesca Regola, Silvia Piantoni, Torsten Lowin, Silvia Archetti, Rossella Reggia, Rajesh Kumar, Franco Franceschini, Paolo Airò, Angela Tincani, Laura Andreoli, Georg Pongratz
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Introduction: Belimumab is a monoclonal antibody against soluble BLyS used for treatment of refractory Systemic Lupus Erythematosus (SLE). Although B cells are the main target of this therapy, a BLyS-dependent T cell activation pathway has also been
Externí odkaz:
https://doaj.org/article/4071a9122a604a739cf044eede64af12