Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Georg, Kochs"'
Autor:
Valter Bergant, Daniel Schnepf, Niklas de Andrade Krätzig, Philipp Hubel, Christian Urban, Thomas Engleitner, Ronald Dijkman, Bernhard Ryffel, Katja Steiger, Percy A. Knolle, Georg Kochs, Roland Rad, Peter Staeheli, Andreas Pichlmair
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Changes of mRNA 3’UTRs by alternative polyadenylation (APA) have been associated to numerous pathologies, but the mechanisms and consequences often remain enigmatic. By combining transcriptomics, proteomics and recombinant viruses we show
Externí odkaz:
https://doaj.org/article/41b117276b3642cfa472a74a5a5f4522
Autor:
Lena Jaki, Sebastian Weigang, Lisa Kern, Stefanie Kramme, Antoni G. Wrobel, Andrea B. Grawitz, Philipp Nawrath, Stephen R. Martin, Theo Dähne, Julius Beer, Miriam Disch, Philipp Kolb, Lisa Gutbrod, Sandra Reuter, Klaus Warnatz, Martin Schwemmle, Steven J. Gamblin, Elke Neumann-Haefelin, Daniel Schnepf, Thomas Welte, Georg Kochs, Daniela Huzly, Marcus Panning, Jonas Fuchs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Monoclonal antibodies (mAbs) directed against the spike of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are effective therapeutic options to combat infections in high-risk patients. Here, we report the adaptation of SARS-CoV-
Externí odkaz:
https://doaj.org/article/d61edc8bae2d4d3c8f29f4fd3b6b89ba
Autor:
Martina Anzaghe, Marc A. Niles, Eugenia Korotkova, Monica Dominguez, Stefanie Kronhart, Samira Ortega Iannazzo, Ingo Bechmann, Malte Bachmann, Heiko Mühl, Georg Kochs, Zoe Waibler
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Type I interferons (IFN) are pro-inflammatory cytokines which can also exert anti-inflammatory effects via the regulation of interleukin (IL)-1 family members. Several studies showed that interferon receptor (IFNAR)-deficient mice develop severe live
Externí odkaz:
https://doaj.org/article/1ddca19e91e5403ebf5404802d5f9fbd
Autor:
Matthias Reinscheid, Hendrik Luxenburger, Vivien Karl, Anne Graeser, Sebastian Giese, Kevin Ciminski, David B. Reeg, Valerie Oberhardt, Natascha Roehlen, Julia Lang-Meli, Kathrin Heim, Nina Gross, Christina Baum, Siegbert Rieg, Claudius Speer, Florian Emmerich, Susanne Breisinger, Daniel Steinmann, Bertram Bengsch, Tobias Boettler, Georg Kochs, Martin Schwemmle, Robert Thimme, Christoph Neumann-Haefelin, Maike Hofmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Vaccines induce beneficial immunity for COVID-19, but immune waning prompts boosting vaccination. Here, the authors show that a third, boosting dose of COVID-19 mRNA vaccine induces transient CD8 + T effector cell response while conserving the CD8 me
Externí odkaz:
https://doaj.org/article/fca8aca08c224586bb686b0fe9b5ffd3
Autor:
Adriano Taddeo, Inês Berenguer Veiga, Christelle Devisme, Renate Boss, Philippe Plattet, Sebastian Weigang, Georg Kochs, Volker Thiel, Charaf Benarafa, Gert Zimmer
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-15 (2022)
Abstract Immunization with vesicular stomatitis virus (VSV)-vectored COVID-19 vaccine candidates expressing the SARS-CoV-2 spike protein in place of the VSV glycoprotein relies implicitly on expression of the ACE2 receptor at the muscular injection s
Externí odkaz:
https://doaj.org/article/716d465de78146a48f5a2e2fd99ad5f7
Autor:
Tamara Kaleta, Lisa Kern, Samuel Leandro Hong, Martin Hölzer, Georg Kochs, Julius Beer, Daniel Schnepf, Martin Schwemmle, Nena Bollen, Philipp Kolb, Magdalena Huber, Svenja Ulferts, Sebastian Weigang, Gytis Dudas, Alice Wittig, Lena Jaki, Abdou Padane, Adamou Lagare, Mounerou Salou, Egon Anderson Ozer, Ndodo Nnaemeka, John Kofi Odoom, Robert Rutayisire, Alia Benkahla, Chantal Akoua-Koffi, Abdoul-Salam Ouedraogo, Etienne Simon-Lorière, Vincent Enouf, Stefan Kröger, Sébastien Calvignac-Spencer, Guy Baele, Marcus Panning, Jonas Fuchs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The A.27 SARS-CoV-2 lineage spread globally in 2021 but did not become dominant. Here, the authors show that A.27 shares some mutations in the spike gene that are present in variants of concern, but lacks the D614G mutation, indicating independent ev
Externí odkaz:
https://doaj.org/article/95413bc995ee4d938afb0a7f4c3cfaa7
Autor:
Sebastian Weigang, Jonas Fuchs, Gert Zimmer, Daniel Schnepf, Lisa Kern, Julius Beer, Hendrik Luxenburger, Jakob Ankerhold, Valeria Falcone, Janine Kemming, Maike Hofmann, Robert Thimme, Christoph Neumann-Haefelin, Svenja Ulferts, Robert Grosse, Daniel Hornuss, Yakup Tanriver, Siegbert Rieg, Dirk Wagner, Daniela Huzly, Martin Schwemmle, Marcus Panning, Georg Kochs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, in a longitudinal case study, Weigang et al. demonstrate that evolution of SARS-CoV-2 within a persistently infected immunosuppressed patient can result in the emergence of novel variants with reduced sensitivity to antibody neutralization.
Externí odkaz:
https://doaj.org/article/fb1ea91842db4a2381c73359e44031ee
Autor:
Manutea C Serrero, Virginie Girault, Sebastian Weigang, Todd M Greco, Ana Ramos-Nascimento, Fenja Anderson, Antonio Piras, Ana Hickford Martinez, Jonny Hertzog, Anne Binz, Anja Pohlmann, Ute Prank, Jan Rehwinkel, Rudolf Bauerfeind, Ileana M Cristea, Andreas Pichlmair, Georg Kochs, Beate Sodeik
Publikováno v:
eLife, Vol 11 (2022)
Host proteins sense viral products and induce defence mechanisms, particularly in immune cells. Using cell-free assays and quantitative mass spectrometry, we determined the interactome of capsid-host protein complexes of herpes simplex virus and iden
Externí odkaz:
https://doaj.org/article/b040d0b00f5e4a9dbd3a033d775dd1a5
Autor:
Marc A. Niles, Patricia Gogesch, Stefanie Kronhart, Samira Ortega Iannazzo, Georg Kochs, Zoe Waibler, Martina Anzaghe
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The exact role of innate immune cells upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their contribution to the formation of the corona virus-induced disease (COVID)-19 associated cytokine storm is not yet fully u
Externí odkaz:
https://doaj.org/article/f63d7aa6893349199e5e2e511cd772da
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 7, Pp 1304-1313 (2019)
Bourbon virus (BRBV) is a recently discovered tick-transmitted viral pathogen that is prevalent in the Midwest and southern United States. Since 2014, zoonotic BRBV infections have been verified in several human cases of severe febrile illness, occas
Externí odkaz:
https://doaj.org/article/e4524df3d8554fcdadbcd5a374bd83f8