Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Georg, Gasteiger"'
Autor:
Abdallah Gaballa, Anneli Gebhardt-Wolf, Bastian Krenz, Greta Mattavelli, Mara John, Giacomo Cossa, Silvia Andreani, Christina Schülein-Völk, Francisco Montesinos, Raphael Vidal, Carolin Kastner, Carsten P. Ade, Burkhard Kneitz, Georg Gasteiger, Peter Gallant, Mathias Rosenfeldt, Angela Riedel, Martin Eilers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase progression and escape from immune surveillance. Here we show that MYC in PDAC cells is needed for the recruitment of the PAF1c transcription elongation compl
Externí odkaz:
https://doaj.org/article/8a9d10af203b42eb8a6cbb3a3a12d74d
Autor:
Hao Wu, Xiufeng Zhao, Sophia M. Hochrein, Miriam Eckstein, Gabriela F. Gubert, Konrad Knöpper, Ana Maria Mansilla, Arman Öner, Remi Doucet-Ladevèze, Werner Schmitz, Bart Ghesquière, Sebastian Theurich, Jan Dudek, Georg Gasteiger, Alma Zernecke, Sebastian Kobold, Wolfgang Kastenmüller, Martin Vaeth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity. Terminally exhausted T cells are steadily replenished by a precu
Externí odkaz:
https://doaj.org/article/8569ec630ff141898b05f8e21eb43d82
Autor:
Knud Esser, Xiaoming Cheng, Jochen M. Wettengel, Julie Lucifora, Lea Hansen-Palmus, Katharina Austen, Armando A. Roca Suarez, Sarah Heintz, Barbara Testoni, Firat Nebioglu, Minh Tu Pham, Shangqing Yang, Alma Zernecke, Dirk Wohlleber, Marc Ringelhan, Mathias Broxtermann, Daniel Hartmann, Norbert Hüser, Julia Mergner, Andreas Pichlmair, Wolfgang E. Thasler, Mathias Heikenwalder, Georg Gasteiger, Andreas Blutke, Axel Walch, Percy A. Knolle, Ralf Bartenschlager, Ulrike Protzer
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 2, Pp 201-221 (2023)
Background & Aims: A single hepatitis B virus (HBV) particle is sufficient to establish chronic infection of the liver after intravenous injection, suggesting that the virus targets hepatocytes via a highly efficient transport pathway. We therefore i
Externí odkaz:
https://doaj.org/article/9fd675743fc64b5f93ebf586a31ab2ba
Autor:
Manuel O. Jakob, Daniel Spari, Daniel Sànchez Taltavull, Lilian Salm, Bahtiyar Yilmaz, Rémi Doucet Ladevèze, Catherine Mooser, David Pereyra, Ye Ouyang, Theresa Schmidt, Irene Mattiola, Patrick Starlinger, Deborah Stroka, Franziska Tschan, Daniel Candinas, Georg Gasteiger, Christoph S.N. Klose, Andreas Diefenbach, Mercedes Gomez de Agüero, Guido Beldi
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112269- (2023)
Summary: It is generally believed that environmental or cutaneous bacteria are the main origin of surgical infections. Therefore, measures to prevent postoperative infections focus on optimizing hygiene and improving asepsis and antisepsis. In a larg
Externí odkaz:
https://doaj.org/article/c73c0b7cf4aa4763ab2085992ed320f3
Autor:
Gabriela M. Wiedemann, Simon Grassmann, Colleen M. Lau, Moritz Rapp, Alejandro V. Villarino, Christin Friedrich, Georg Gasteiger, John J. O’Shea, Joseph C. Sun
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108498- (2020)
Summary: Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory. Because signal transducer and activator of transcription 5 (STAT5) is essential for NK cell
Externí odkaz:
https://doaj.org/article/cd2ef75af09d4bb1bf1ac555481e0d9d
Autor:
Henrik Einwächter, Alexander Heiseke, Andreas Schlitzer, Georg Gasteiger, Heiko Adler, David Voehringer, Markus G. Manz, Zsolt Ruzsics, Lars Dölken, Ulrich H. Koszinowski, Tim Sparwasser, Wolfgang Reindl, Stefan Jordan
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Dendritic cells (DC) play a key role in the adaptive immune response due to their ability to present antigens and stimulate naïve T cells. Many bacteria and viruses can efficiently target DC, resulting in impairment of their immunostimulatory functi
Externí odkaz:
https://doaj.org/article/383234907d7a4f3ca0318070749c03a8
Autor:
Tobias Straub, Marina A. Freudenberg, Ulrike Schleicher, Christian Bogdan, Georg Gasteiger, Hanspeter Pircher
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Exposure to multiple pathogens is common in nature, yet interactions between the immune components targeting bacterial and viral pathogens during co-infection are poorly understood. Here the authors show that bacteria-derived LPS induces cytotoxic NK
Externí odkaz:
https://doaj.org/article/ea8d1ad39a4f4d37855579d39f274857
Autor:
Blossom Akagbosu, Zakieh Tayyebi, Gayathri Shibu, Yoselin A. Paucar Iza, Deeksha Deep, Yollanda Franco Parisotto, Logan Fisher, H. Amalia Pasolli, Valentin Thevin, Rasa Elmentaite, Maximilian Knott, Saskia Hemmers, Lorenz Jahn, Christin Friedrich, Jacob Verter, Zhong-Min Wang, Marcel van den Brink, Georg Gasteiger, Thomas G. P. Grünewald, Julien C. Marie, Christina Leslie, Alexander Y. Rudensky, Chrysothemis C. Brown
Publikováno v:
Nature. 610:752-760
Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a criti
Autor:
James P. Allison, Marcel R. M. van den Brink, Peter A. Savage, Georg Gasteiger, Rebecca Waitz, Joyce Wei, Rajmohan Murali, Stefan Haak, Katharina Kreymborg
The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d829ed93c60e41d989d7be77883f6cf3
https://doi.org/10.1158/2326-6066.c.6548447.v1
https://doi.org/10.1158/2326-6066.c.6548447.v1
Autor:
James P. Allison, Marcel R. M. van den Brink, Peter A. Savage, Georg Gasteiger, Rebecca Waitz, Joyce Wei, Rajmohan Murali, Stefan Haak, Katharina Kreymborg
Supplementary Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b727a481c7b56ef303543c8ef459b9
https://doi.org/10.1158/2326-6066.22537442.v1
https://doi.org/10.1158/2326-6066.22537442.v1