Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Geok Lin Chua"'
Autor:
Cheen Fei Chin, Dwight L.A. Galam, Liang Gao, Bryan C. Tan, Bernice H. Wong, Geok-Lin Chua, Randy Y.J. Loke, Yen Ching Lim, Markus R. Wenk, Miao-Shan Lim, Wei-Qiang Leow, George B.B. Goh, Federico Torta, David L. Silver
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
The liver has a high demand for phosphatidylcholine (PC), particularly in overnutrition, where reduced phospholipid levels have been implicated in the development of nonalcoholic fatty liver disease (NAFLD). Whether other pathways exist in addition t
Externí odkaz:
https://doaj.org/article/65986795ef3e486290872e1e79aa32e1
Autor:
Randy Y.J. Loke, Cheen Fei Chin, Gao Liang, Bernice H. Wong, Dwight L.A. Galam, Bryan C. Tan, Geok-Lin Chua, Shintaro Minegishi, Norihiko Morisawa, Iulia Sidorov, Bram Heijs, Jens Titze, Markus R. Wenk, Federico Torta, David L. Silver
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 8, Pp 100416- (2023)
Acute kidney injury (AKI) is a global public health concern with high mortality and morbidity. In ischemic–reperfusion injury (IRI), a main cause of AKI, the brush border membrane of S3 proximal tubules (PT) is lost to the tubular lumen. How injure
Externí odkaz:
https://doaj.org/article/672d13e383c743709655a740077d87eb
Autor:
Menglan He, Alvin C. Y. Kuk, Mei Ding, Cheen Fei Chin, Dwight L.A. Galam, Jie Min Nah, Bryan C. Tan, Hui Li Yeo, Geok Lin Chua, Peter I. Benke, Markus R. Wenk, Lena Ho, Federico Torta, David L. Silver
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(40)
The lysosome is central to the degradation of proteins, carbohydrates, and lipids and their salvage back to the cytosol for reutilization. Lysosomal transporters for amino acids, sugars, and cholesterol have been identified, and the metabolic fates o
Autor:
Geok-Lin Chua, Bryan C. Tan, Randy Y. J. Loke, Menglan He, Cheen-Fei Chin, Bernice H. Wong, Alvin C. Y. Kuk, Mei Ding, Markus R. Wenk, Lan Guan, Federico Torta, David L. Silver
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Major Facilitator Superfamily Domain containing 2a (Mfsd2a) is a sodium-dependent lysophosphatidylcholine (LPC) transporter expressed at the blood–brain barrier that constitutes the main pathway by which the brain obtains omega-3 fatty acids, such
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153501 (2016)
Kindlins-1,2 and 3 are FERM domain-containing cytosolic proteins involved in the activation and regulation of integrin-mediated cell adhesion. Apart from binding to integrin β cytosolic tails, kindlins and the well characterized integrin-activator t
Externí odkaz:
https://doaj.org/article/0567c952937c40b38fe6789a31bc454c
Autor:
Pasquale Striano, Ehsan Ghayoor Karimiani, Vincenzo Salpietro, Hao Fan, Yasser Sabr, Cheen Fei Chin, Emer O'Connor, Henry Houlden, Saima Riazuddin, Hessa S. Alsaif, David L. Silver, Elena L. Dadali, Yalda Jamshidi, Artem Borovikov, Galina Baydakova, F. A. Konovalov, Reza Maroofian, Fowzan S. Alkuraya, Mehran Beiraghi Toosi, M. Chiara Manzini, Mariasavina Severino, Federico Zara, Alvin Kuk, Abdullah Alfaifi, Ekaterina R. Lozier, Farah Ashrafzadeh, Marcello Scala, Geok Lin Chua, Mohammad Doosti, Sheikh Riazuddin
Publikováno v:
Eur J Hum Genet
Web of Science
Web of Science
Major Facilitator Superfamily Domain containing 2a (MFSD2A) is an essential endothelial lipid transporter at the blood-brain barrier. Biallelic variants affecting function in MFSD2A cause autosomal recessive primary microcephaly 15 (MCPH15, OMIM# 616
Autor:
Menglan He, Kuk, Mei Ding, Cheen Fei Chin, Galam, Dwight L. A., Jie Min Nah, Tan, Bryan C., Hui Li Yeo, Geok Lin Chua, Benke, Peter I., Wenk, Markus R., Lena Ho, Torta, Federico, Silver, David L.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 10/4/2022, Vol. 119 Issue 40, p1-9, 9p
Autor:
Geok Lin Chua, Joseph G. Pepe, James E. Keener, Cheen Fei Chin, David L. Silver, Michael T. Marty, Rosemary J. Cater, Oliver B. Clarke, Satchal K. Erramilli, Giacomo Parisi, Brendon C. Choy, Brian Kloss, Filippo Mancia, George Khelashvili, Piotr Tokarz, Anthony A. Kossiakoff, Debra Q Y Quek, Bernice H. Wong
Publikováno v:
Nature
Docosahexaenoic acid is an omega-3 fatty acid that is essential for neurological development and function, and it is supplied to the brain and eyes predominantly from dietary sources1–6. This nutrient is transported across the blood–brain and blo
Autor:
Bernice H. Wong, Ding Mei, Geok Lin Chua, Dwight L. Galam, Markus R. Wenk, Federico Torta, David L. Silver
Publikováno v:
Journal of Biological Chemistry. 298:101709
Pulmonary surfactant is a lipoprotein complex essential for lung function, and insufficiency or altered surfactant composition is associated with major lung diseases, such as acute respiratory distress syndromes, idiopathic pulmonary fibrosis, and ch
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55184 (2013)
BACKGROUND: Integrins are a group of transmembrane signaling proteins that are important in biological processes such as cell adhesion, proliferation and migration. Integrins are α/β hetero-dimers and there are 24 different integrins formed by spec
Externí odkaz:
https://doaj.org/article/0a53493a9e0642aaa347ef5ccec3be64