Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Geok Choo Sim"'
Autor:
William W. Tseng, Shruti Malu, Minying Zhang, Jieqing Chen, Geok Choo Sim, Wei Wei, Davis Ingram, Neeta Somaiah, Dina C. Lev, Raphael E. Pollock, Gregory Lizée, Laszlo Radvanyi, Patrick Hwu
Publikováno v:
Sarcoma, Vol 2015 (2015)
Treatment options are limited in well differentiated (WD) and dedifferentiated (DD) retroperitoneal liposarcoma. We sought to study the intratumoral adaptive immune response and explore the potential feasibility of immunotherapy in this disease. Tumo
Externí odkaz:
https://doaj.org/article/ca8bc235dc1346d791c249d992d4594b
Autor:
Laszlo Radvanyi, Elizabeth Grimm, Patrick Hwu, Francesco Marincola, Jason Roszik, Willem W. Overwijk, Zhimin Dai, Caitlin Creasy, Hui Liu, Ena Wang, Chengwen Liu, Geok Choo Sim
Additional information for materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080fd0a041d1546cd30bed7e4d0ba031
https://doi.org/10.1158/2326-6066.22538761.v1
https://doi.org/10.1158/2326-6066.22538761.v1
Autor:
Laszlo Radvanyi, Elizabeth Grimm, Patrick Hwu, Francesco Marincola, Jason Roszik, Willem W. Overwijk, Zhimin Dai, Caitlin Creasy, Hui Liu, Ena Wang, Chengwen Liu, Geok Choo Sim
Supplementary figure legend 1-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc2ba2952a4e3c7733aae246064ce2a
https://doi.org/10.1158/2326-6066.22538758.v1
https://doi.org/10.1158/2326-6066.22538758.v1
Autor:
Laszlo Radvanyi, Elizabeth Grimm, Patrick Hwu, Francesco Marincola, Jason Roszik, Willem W. Overwijk, Zhimin Dai, Caitlin Creasy, Hui Liu, Ena Wang, Chengwen Liu, Geok Choo Sim
Supplementary Figure 1. Dose response in Treg and NK cell subsets upon WT IL-2 or F42K stimulation Supplementary Figure 2. Gating strategy for Tregs upon WT IL-2 or F42K stimulation Supplementary Figure 3. CD127 expression by ICOS+ Tregs and CD4+Foxp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157016cec208e553b146ca302ce71936
https://doi.org/10.1158/2326-6066.22538764.v1
https://doi.org/10.1158/2326-6066.22538764.v1
Autor:
Willem W. Overwijk, Patrick Hwu, Francesco M. Marincola, Geok Choo Sim, Caitlin Creasy, Laszlo Radvanyi, Chengwen Liu, Elizabeth A. Grimm, Hui Liu, Zhimin Dai, Ena Wang, Jason Roszik
Publikováno v:
Cancer Immunology Research. 4:983-994
Clinical responses to high-dose IL2 therapy are limited due to selective expansion of CD4+CD25+Foxp3+ T-regulatory cells (Treg), especially ICOS+ Tregs, rather than natural killer (NK) cells and effector T cells. These ICOS+ Tregs are highly suppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f110f5c88dc7d4a0623bdaa279a97e1
https://doi.org/10.1158/2326-6066.cir-15-0195
https://doi.org/10.1158/2326-6066.cir-15-0195
Publikováno v:
Oncotarget
High dose (HD) IL-2 therapy has been used for almost two decades as an immunotherapy for metastatic melanoma. IL-2 promotes the proliferation and effector function of T and NK cells through the tyrosine phosphorylation and activation of signal transd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf50772f4a37ab090d703f4ad37b4364
https://doi.org/10.18632/oncotarget.8683
https://doi.org/10.18632/oncotarget.8683
Autor:
Krit Ritthipichai, Laszlo Radvanyi, Manish Singh, Jessica Ann Chacon, Cara Haymaker, Patrick Hwu, Geok Choo Sim
Publikováno v:
BioDrugs. 28:421-437
Cancer immunotherapy has become an important area for the future development of cancer therapy; this includes T-cell-based therapies that involve adoptive transfer of autologous T cells derived from the tumors or peripheral blood of cancer patients,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1712d6555ff1f7c7ed280c344a2960
https://doi.org/10.1007/s40259-014-0097-y
https://doi.org/10.1007/s40259-014-0097-y
Autor:
Marat Alimzhanov, Patricia Soulard, Astrid Zimmermann, Andreas Schroeder, Keyvan Tadjalli Mehr, Christiane Amendt, Geok Choo Sim, Andree Blaukat, Joern-Peter Halle, Frank T. Zenke
Publikováno v:
Cancer Research. 79:2269-2269
Recently, combination of checkpoint inhibitors with chemotherapy demonstrated significant improvement of overall survival (OS) and progression-free survival (PFS) compared with chemotherapy alone in patients with metastatic non-squamous and squamous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14a6d6b46bdc17d2ea07c237eebf88ff
https://doi.org/10.1158/1538-7445.am2019-2269
https://doi.org/10.1158/1538-7445.am2019-2269
Autor:
Laszlo Radvanyi, Sheng Wu, Carol Lacey, Edwina Washington, Deborah Sanders, Patrick Hwu, Natalia Martin-Orozco, Yan Yang, Yijun Wang, Geok Choo Sim, Lei Jin, Luis M Vence
Publikováno v:
Journal of Clinical Investigation. 124:99-110
High-dose (HD) IL-2 therapy in patients with cancer increases the general population of Tregs, which are positive for CD4, CD25, and the Treg-specific marker Foxp3. It is unknown whether specific subsets of Tregs are activated and expanded during HD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1049df2ed44d0e8af889a8afa7ec3f
https://doi.org/10.1172/jci46266
https://doi.org/10.1172/jci46266
Autor:
Cara Haymaker, Jie Qing Chen, Laszlo Radvanyi, Chantale Bernatchez, Geok Choo Sim, Marie-Andree Forget
Publikováno v:
Genetics of Melanoma ISBN: 9781493935529
A hallmark of melanoma is its inherent immunogenicity through both innate and adaptive immune mechanisms. However, a number of factors inhibit these immune responses through intrinsic mechanisms in tumor cells or adaptive resistance triggered by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edbbf553eaea5565401122f0f8350b9d
https://doi.org/10.1007/978-1-4939-3554-3_2
https://doi.org/10.1007/978-1-4939-3554-3_2