Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Geoffry L Curran"'
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97655 (2014)
BACKGROUND: Rapid pre-clinical evaluation of chemotherapeutic agents against brain cancers and other neurological disorders remains largely unattained due to the presence of the blood-brain barrier (BBB), which limits transport of most therapeutic co
Externí odkaz:
https://doaj.org/article/364e7d01a90548948e0ee5337b1f1b48
Autor:
Christine Song, Dawa Jung, Ayse Tuba Kendi, Jin Kyung Rho, Eun-Joo Kim, Ian Horn, Geoffry L. Curran, Sujala Ghattamaneni, Ji Yeon Shim, Pil Soo Kang, Daehun Kang, Jay B. Thakkar, Sannidhi Dewan, Val J. Lowe, Seung Baek Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7494 (2024)
Women with type 2 diabetes (T2D) have a higher risk of being diagnosed with breast cancer and have worse survival than non-diabetic women if they do develop breast cancer. However, more research is needed to elucidate the biological underpinnings of
Externí odkaz:
https://doaj.org/article/e9136e9e4e914459aa0afd7ac8cfc69c
Autor:
Jameel Ahmad Khan, Rachel A Kudgus, Annamaria Szabolcs, Shamit Dutta, Enfeng Wang, Sheng Cao, Geoffry L Curran, Vijay Shah, Steven Curley, Debabrata Mukhopadhyay, J David Robertson, Resham Bhattacharya, Priyabrata Mukherjee
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20347 (2011)
Pancreatic cancer is the fourth leading cause of cancer related deaths in America. Monoclonal antibodies are a viable treatment option for inhibiting cancer growth. Tumor specific drug delivery could be achieved utilizing these monoclonal antibodies
Externí odkaz:
https://doaj.org/article/497c8f08d43c4e7ab533a0da035e895e
Autor:
Gobinda Sarkar, Geoffry L Curran, Eric Mahlum, Teresa Decklever, Thomas M Wengenack, Anthony Blahnik, Bridget Hoesley, Val J Lowe, Joseph F Poduslo, Robert B Jenkins
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28881 (2011)
BACKGROUND: Therapeutic intervention of numerous brain-associated disorders currently remains unrealized due to serious limitations imposed by the blood-brain-barrier (BBB). The BBB generally allows transport of small molecules, typically
Externí odkaz:
https://doaj.org/article/d838b4f4789547e29fc90563cbf78dfb
Autor:
Joseph F Poduslo, Emily J Gilles, Muthu Ramakrishnan, Kyle G Howell, Thomas M Wengenack, Geoffry L Curran, Karunya K Kandimalla
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8813 (2010)
A key question in understanding AD is whether extracellular Abeta deposition of parenchymal amyloid plaques or intraneuronal Abeta accumulation initiates the AD process. Amyloid precursor protein (APP) is endocytosed from the cell surface into endoso
Externí odkaz:
https://doaj.org/article/5ff11315eb4f4f3380ca8c134934701c
Autor:
Andrew L, Zhou, Nidhi, Sharda, Vidur V, Sarma, Kristen M, Ahlschwede, Geoffry L, Curran, Xiaojia, Tang, Joseph F, Poduslo, Krishna R, Kalari, Val J, Lowe, Karunya K, Kandimalla
Publikováno v:
Journal of Alzheimer's Disease. 85:1031-1044
Background: Age is the most common risk factor for Alzheimer’s disease (AD), a neurodegenerative disorder characterized by the hallmarks of toxic amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles. Moreover, sub-physiological brain insuli
Autor:
Heather M. Stein, Surendra R. Gundam, Aditya Bansal, Nicholas R. Nelson, Geoffry L. Curran, Timothy R. DeGrado, Mark A. Frye, John D. Port, Val J. Lowe, Melissa E. Murray, Mukesh K. Pandey
Publikováno v:
European Journal of Organic Chemistry. 26
Disruptions in glucose uptake and metabolism in the brain are implicated in metabolic disorders and Alzheimer’s disease (AD). Toxic soluble amyloid-beta (sAß) peptides accumulating in the brain and plasma of AD patients were suggested to promote b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1fa4cfd87c995d7ff559f8e0aa7b72
https://doi.org/10.1101/2022.11.21.517280
https://doi.org/10.1101/2022.11.21.517280
Autor:
Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L. Curran, Paul H. Min, Ronald A. Siegel, Val J. Lowe, Karunya K. Kandimalla
Plasma pharmacokinetic (PK) data is required as an input function for graphical analysis (e.g., Patlak plot) of single positron emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/CT (PET/CT) data to evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e2d24190d0dc73df5c9cb36b634f20f
https://doi.org/10.1101/2022.11.17.517003
https://doi.org/10.1101/2022.11.17.517003
Autor:
Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L Curran, Paul H. Min, Ronald A. Siegel, Val J Lowe, Karunya K. Kandimalla
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. :JPET-AR