Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Geoffry L Curran"'
Autor:
Christine Song, Dawa Jung, Ayse Tuba Kendi, Jin Kyung Rho, Eun-Joo Kim, Ian Horn, Geoffry L. Curran, Sujala Ghattamaneni, Ji Yeon Shim, Pil Soo Kang, Daehun Kang, Jay B. Thakkar, Sannidhi Dewan, Val J. Lowe, Seung Baek Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7494 (2024)
Women with type 2 diabetes (T2D) have a higher risk of being diagnosed with breast cancer and have worse survival than non-diabetic women if they do develop breast cancer. However, more research is needed to elucidate the biological underpinnings of
Externí odkaz:
https://doaj.org/article/e9136e9e4e914459aa0afd7ac8cfc69c
Autor:
Andrew L, Zhou, Nidhi, Sharda, Vidur V, Sarma, Kristen M, Ahlschwede, Geoffry L, Curran, Xiaojia, Tang, Joseph F, Poduslo, Krishna R, Kalari, Val J, Lowe, Karunya K, Kandimalla
Publikováno v:
Journal of Alzheimer's Disease. 85:1031-1044
Background: Age is the most common risk factor for Alzheimer’s disease (AD), a neurodegenerative disorder characterized by the hallmarks of toxic amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles. Moreover, sub-physiological brain insuli
Autor:
Heather M. Stein, Surendra R. Gundam, Aditya Bansal, Nicholas R. Nelson, Geoffry L. Curran, Timothy R. DeGrado, Mark A. Frye, John D. Port, Val J. Lowe, Melissa E. Murray, Mukesh K. Pandey
Publikováno v:
European Journal of Organic Chemistry. 26
Disruptions in glucose uptake and metabolism in the brain are implicated in metabolic disorders and Alzheimer’s disease (AD). Toxic soluble amyloid-beta (sAß) peptides accumulating in the brain and plasma of AD patients were suggested to promote b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1fa4cfd87c995d7ff559f8e0aa7b72
https://doi.org/10.1101/2022.11.21.517280
https://doi.org/10.1101/2022.11.21.517280
Autor:
Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L. Curran, Paul H. Min, Ronald A. Siegel, Val J. Lowe, Karunya K. Kandimalla
Plasma pharmacokinetic (PK) data is required as an input function for graphical analysis (e.g., Patlak plot) of single positron emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/CT (PET/CT) data to evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e2d24190d0dc73df5c9cb36b634f20f
https://doi.org/10.1101/2022.11.17.517003
https://doi.org/10.1101/2022.11.17.517003
Autor:
Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L Curran, Paul H. Min, Ronald A. Siegel, Val J Lowe, Karunya K. Kandimalla
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. :JPET-AR
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:482-490
Blood-brain barrier (BBB) endothelial cells lining the cerebral microvasculature maintain dynamic equilibrium between soluble amyloid-β (Aβ) levels in the brain and plasma. The BBB dysfunction prevalent in Alzheimer disease contributes to the dysre
Autor:
Kristen M. Ahlschwede, Geoffry L. Curran, Karunya K. Kandimalla, Val J. Lowe, Ling Li, Suresh Kumar Swaminathan, Andrew L Zhou
Publikováno v:
J Pharmacol Exp Ther
Treatments to elevate high-density lipoprotein (HDL) levels in plasma have decreased cerebrovascular amyloid -β (Aβ) deposition and mitigated cognitive decline in Alzheimer disease (AD) transgenic mice. Since the major protein component of HDL part
Publikováno v:
Mol Pharm
Elevated exposure to toxic amyloid beta (Aβ) peptides and consequent blood–brain barrier (BBB) dysfunction are believed to promote vasculopathy in Alzheimer’s disease (AD). However, the accumulation kinetics of different Aβ isoforms within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d0477ff8d6bcd69581102c648262c1
https://europepmc.org/articles/PMC9113734/
https://europepmc.org/articles/PMC9113734/
Autor:
Joseph F. Poduslo, Thomas M. Wengenack, Geoffry L. Curran, Thomas Wisniewski, Einar M. Sigurdsson, Slobodon I. Macura, Bret J. Borowski, Clifford R. Jack, Jr.
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 2, Pp 315-329 (2002)
Smart molecular probes for both diagnostic and therapeutic purposes are expected to provide significant advances in clinical medicine and biomedical research. We describe such a probe that targets β-amyloid plaques of Alzheimer's disease and is dete
Externí odkaz:
https://doaj.org/article/956358b699344db491ef06e23ce8cc42