Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Geoffroy de Bettignies"'
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117857 (2015)
Kif23 kinesin is an essential actor of cytokinesis in animals. It exists as two major isoforms, known as MKLP1 and CHO1, the longest of which, CHO1, contains two HXRXXS/T NDR/LATS kinase consensus sites. We demonstrate that these two sites are readil
Externí odkaz:
https://doaj.org/article/45b5b4aa6ccb431090eafdaa04dfb71e
Autor:
Eudoxie Dulary, Thorsten Marquardt, Willy Morelle, Marie-Ange Krzewinski-Recchi, Marine Houdou, Romain Péanne, Corentin Spriet, Dorothée Vicogne, André Klein, François Foulquier, Geoffroy de Bettignies, Vladimir Lupashin, Sven Potelle, Sandrine Duvet, Leslie K. Climer, Gert Matthijs, Pierre Morsomme, Elodie Lebredonchel
Publikováno v:
Biochemical Journal
Biochemical Journal, 2017, 474 (9), pp.1481-1493. ⟨10.1042/BCJ20160910⟩
Biochemical Journal, 2017, 474 (9), pp.1481-1493. ⟨10.1042/BCJ20160910⟩
International audience; TMEM165 deficiencies lead to one of the congenital disorders of glycosylation (CDG), a group of inherited diseases where the glycosylation process is altered. We recently demonstrated that the Golgi glycosylation defect due to
Autor:
Anne-Marie Mir, François Foulquier, Marie-Ange Krzewinski-Recchi, Eudoxie Dulary, Willy Morelle, Dorothée Vicogne, Geoffroy de Bettignies, Sven Potelle, Sandrine Duvet
Publikováno v:
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, 2017, Biochimica et biophysica acta, 1861 (4), pp.737-748. ⟨10.1016/j.bbagen.2017.01.011⟩
BBA-Biochimica et Biophysica Acta, Elsevier, 2017, Biochimica et biophysica acta, 1861 (4), pp.737-748. ⟨10.1016/j.bbagen.2017.01.011⟩
BBA-Biochimica et Biophysica Acta, 2017, Biochimica et biophysica acta, 1861 (4), pp.737-748. ⟨10.1016/j.bbagen.2017.01.011⟩
BBA-Biochimica et Biophysica Acta, Elsevier, 2017, Biochimica et biophysica acta, 1861 (4), pp.737-748. ⟨10.1016/j.bbagen.2017.01.011⟩
International audience; BACKGROUND: Defects in TMEM165 gene cause a type-II Congenital Disorder of Glycosylation affecting Golgi glycosylation processes. TMEM165 patients exhibit psychomotor retardation, important osteoporosis, scoliosis, irregular e
Autor:
Elodie, Lebredonchel, Marine, Houdou, Sven, Potelle, Geoffroy, de Bettignies, Céline, Schulz, Marie-Ange, Krzewinski Recchi, Vladimir, Lupashin, Dominique, Legrand, André, Klein, François, Foulquier
Publikováno v:
Biochimie. 165
Since 2012, the interest for TMEM165 increased due to its implication in a rare genetic human disease named TMEM165-CDG (Congenital Disorder(s) of Glycosylation). TMEM165 is a Golgi localized protein, highly conserved through evolution and belonging
Autor:
Gert Matthijs, Valérie Decool, Sven Potelle, Marine Houdou, Eudoxie Dulary, Sandrine Duvet, Yann Guérardel, François Foulquier, Marie-Ange Krzewinski-Recchi, Shin-Yi Yu, Geoffroy de Bettignies, Anne Garat
Publikováno v:
Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2018, 1862 (3), pp.394-402. ⟨10.1016/j.bbagen.2017.11.006⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, 2018, 1862 (3), pp.394-402. ⟨10.1016/j.bbagen.2017.11.006⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2018, 1862 (3), pp.394-402. ⟨10.1016/j.bbagen.2017.11.006⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, 2018, 1862 (3), pp.394-402. ⟨10.1016/j.bbagen.2017.11.006⟩
The Golgi ion homeostasis is tightly regulated to ensure essential cellular processes such as glycosylation, yet our understanding of this regulation remains incomplete. Gdt1p is a member of the conserved Uncharacterized Protein Family (UPF0016). Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cc36d00669252522f3cccd2513f03d
https://hal.archives-ouvertes.fr/hal-02371931
https://hal.archives-ouvertes.fr/hal-02371931
Autor:
Geoffroy de Bettignies, Olivier Coux
Publikováno v:
Biochimie. 92:1530-1545
The discovery of the proteasome in the late 80's as the core protease of what will be then called the ubiquitin-proteasome system, rapidly followed by the development of specific inhibitors of this enzyme, opened up a new era in biology in the 90's.
Publikováno v:
Genetics. 159:1435-1448
The nonessential RGD1 gene encodes a Rho-GTPase activating protein for the Rho3 and Rho4 proteins in Saccharomyces cerevisiae. Previous studies have revealed genetic interactions between RGD1 and the SLG1 and MID2 genes, encoding two putative sensors
Autor:
Geoffroy de Bettignies, Christophe Barthe, Carine Morel, Marie France Peypouquet, François Doignon, Marc Crouzet
Publikováno v:
Yeast. 15:1719-1731
The RGD1 gene was identified during systematic genome sequencing of Saccharomyces cerevisiae. To further understand Rgd1p function, we set up a synthetic lethal screen for genes interacting with RGD1. Study of one lethal mutant made it possible to id
Autor:
Cindy Borrego, François Foulquier, Pierre Morsomme, Gert Matthijs, Didier Demaegd, Dominique Legrand, Riet Bammens, Hêla Hacine-Gherbi, Claire Rosnoblet, Geoffroy de Bettignies, Sandrine Duvet
Publikováno v:
Human molecular genetics
Human molecular genetics online, 2013, Human Molecular Genetics, 22 (14), pp.2914-2928. ⟨10.1093/hmg/ddt146⟩
Human Molecular Genetics
Human Molecular Genetics, 2013, Human Molecular Genetics, 22 (14), pp.2914-2928. ⟨10.1093/hmg/ddt146⟩
Human molecular genetics online, 2013, Human Molecular Genetics, 22 (14), pp.2914-2928. ⟨10.1093/hmg/ddt146⟩
Human Molecular Genetics
Human Molecular Genetics, 2013, Human Molecular Genetics, 22 (14), pp.2914-2928. ⟨10.1093/hmg/ddt146⟩
TMEM165 has recently been identified as a novel protein involved in CDG-II. TMEM165 has no biological function described so far. Different mutations were recently found in patients with Golgi glycosylation defects and harboring a peculiar skeletal ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa14121e8d3984d8584c161ed723a11a
https://hal.univ-lille.fr/hal-03159619
https://hal.univ-lille.fr/hal-03159619
Publikováno v:
Biology of the Cell
Biology of the Cell, Wiley, 2012, 104 (3), pp.165-187. ⟨10.1111/boc.201100112⟩
Biology of the Cell, Wiley, 2012, 104 (3), pp.165-187. ⟨10.1111/boc.201100112⟩
The modification of intracellular proteins by ubiquitin (Ub) and ubiquitin-like (UbL) proteins is a central mechanism for regulating and fine-tuning all cellular processes. Indeed, these modifications are widely used to control the stability, activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6437cf28b025f895fc5e8b72e033cd0
https://hal.archives-ouvertes.fr/hal-02421867
https://hal.archives-ouvertes.fr/hal-02421867