Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Geoffroy Andrieux"'
Autor:
Susanne Kessler, Bradly Burke, Geoffroy Andrieux, Jan Schinköthe, Lea Hamberger, Johannes Kacza, Shijun Zhan, Clara Reasoner, Taru S. Dutt, Maria Kaukab Osman, Marcela Henao-Tamayo, Julian Staniek, Jose Francisco Villena Ossa, Dalit T. Frank, Wenjun Ma, Reiner Ulrich, Toni Cathomen, Melanie Boerries, Marta Rizzi, Martin Beer, Martin Schwemmle, Peter Reuther, Tony Schountz, Kevin Ciminski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Jamaican fruit bats (Artibeus jamaicensis) naturally harbor a wide range of viruses of human relevance. These infections are typically mild in bats, suggesting unique features of their immune system. To better understand the immune response
Externí odkaz:
https://doaj.org/article/c051c263d7674a128f1b9588cd87ed8d
Autor:
Nadine Weinelt, Kaja Nicole Wächtershäuser, Gulustan Celik, Birte Jeiler, Isabelle Gollin, Laura Zein, Sonja Smith, Geoffroy Andrieux, Tonmoy Das, Jens Roedig, Leonard Feist, Björn Rotter, Melanie Boerries, Francesco Pampaloni, Sjoerd J. L. van Wijk
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Plasma membrane accumulation of phosphorylated mixed lineage kinase domain-like (MLKL) is a hallmark of necroptosis, leading to membrane rupture and inflammatory cell death. Pro-death functions of MLKL are tightly controlled by several check
Externí odkaz:
https://doaj.org/article/e14e541c4820493ea444b18cd9044345
Autor:
Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Cornelius Miething, Uta S. Martens, Khalid Shoumariyeh, Rosa P. Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R. Blazar, Burkhard Becher, Melanie Boerries, Robert Zeiser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Patients with corticosteroid-refractory acute graft-versus-host disease (aGVHD) have a low one-year survival rate. Identification and validation of novel targetable kinases in patients who experience corticosteroid-refractory-aGVHD may help
Externí odkaz:
https://doaj.org/article/cb63dbf7545c4a79898fb5a39c9842f1
Autor:
Christian Molnar, Sheila Bohler, Jovana Rajak, Julia Miriam Weiss, Irene Gonzalez-Mendez, Geoffroy Andrieux, Eva-Maria Demmerath, Madeleine Wahl, Lena Wendeburg, Gudrun Göhring, Brigitte Strahm, Doris Steinemann, Martina Rudelius, Melanie Börries, Leticia Quintanilla-Martinez, Charlotte M. Niemeyer, Verena Labi, Miriam Erlacher
Publikováno v:
EJC Paediatric Oncology, Vol 2, Iss , Pp 100069- (2023)
Externí odkaz:
https://doaj.org/article/eb53d0919a71441d88fd83a5986a697d
Autor:
Geoffroy Andrieux, Tonmoy Das, Michaela Griffin, Jakob Straehle, Simon M. L. Paine, Jürgen Beck, Melanie Boerries, Dieter H. Heiland, Stuart J. Smith, Ruman Rahman, Sajib Chakraborty
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-34 (2023)
Abstract Background Spatiotemporal heterogeneity originating from genomic and transcriptional variation was found to contribute to subtype switching in isocitrate dehydrogenase-1 wild-type glioblastoma (GBM) prior to and upon recurrence. Fluorescence
Externí odkaz:
https://doaj.org/article/ddc7f16df4c243c3bdd8102718b49299
Autor:
Vigneshwaran Venkatesan, Abisha Crystal Christopher, Manuel Rhiel, Manoj Kumar K. Azhagiri, Prathibha Babu, Kaivalya Walavalkar, Bharath Saravanan, Geoffroy Andrieux, Sumathi Rangaraj, Saranya Srinivasan, Karthik V. Karuppusamy, Annlin Jacob, Abhirup Bagchi, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Rekha Pai, Srujan Kumar Marepally, Kumarasamypet Murugesan Mohankumar, Shaji R. Velayudhan, Melanie Boerries, Dimple Notani, Toni Cathomen, Alok Srivastava, Saravanabhavan Thangavel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 671-688 (2023)
Reactivation of fetal hemoglobin (HbF) is a commonly adapted strategy to ameliorate β-hemoglobinopathies. However, the continued production of defective adult hemoglobin (HbA) limits HbF tetramer production affecting the therapeutic benefits. Here,
Externí odkaz:
https://doaj.org/article/444686798a7c40d7a355be2ff089b162
Autor:
Mariel C. Paul, Christian Schneeweis, Chiara Falcomatà, Chuan Shan, Daniel Rossmeisl, Stella Koutsouli, Christine Klement, Magdalena Zukowska, Sebastian A. Widholz, Moritz Jesinghaus, Konstanze K. Heuermann, Thomas Engleitner, Barbara Seidler, Katia Sleiman, Katja Steiger, Markus Tschurtschenthaler, Benjamin Walter, Sören A. Weidemann, Regina Pietsch, Angelika Schnieke, Roland M. Schmid, Maria S. Robles, Geoffroy Andrieux, Melanie Boerries, Roland Rad, Günter Schneider, Dieter Saur
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
SNAIL promotes tumour metastasis through inducing epithelial to mesenchymal transition (EMT). Here the authors report that SNAIL bypasses senescence and regulates cell cycle progression to promote pancreatic carcinogenesis and this is independent of
Externí odkaz:
https://doaj.org/article/fdf4c0ab459c4aa5ae822ae980ab27e7
Autor:
Ala Dibas, Manuel Rhiel, Vidisha Bhavesh Patel, Geoffroy Andrieux, Melanie Boerries, Tatjana I. Cornu, Jamal Alzubi, Toni Cathomen
Publikováno v:
Cells, Vol 12, Iss 21, p 2581 (2023)
While chimeric antigen receptor (CAR) T cell therapy has shown promising outcomes among patients with hematologic malignancies, it has also been associated with undesirable side-effects such as cytokine release syndrome (CRS). CRS is triggered by CAR
Externí odkaz:
https://doaj.org/article/bf43cad4c6ab4739b2fc2db99a085e44
Autor:
Rebekka Karlowitz, Megan L. Stanifer, Jens Roedig, Geoffroy Andrieux, Denisa Bojkova, Marco Bechtel, Sonja Smith, Lisa Kowald, Ralf Schubert, Melanie Boerries, Jindrich Cinatl, Steeve Boulant, Sjoerd J. L. van Wijk
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-14 (2022)
Abstract Pattern recognition receptors (PRRs) and interferons (IFNs) serve as essential antiviral defense against SARS-CoV-2, the causative agent of the COVID-19 pandemic. Type III IFNs (IFN-λ) exhibit cell-type specific and long-lasting functions i
Externí odkaz:
https://doaj.org/article/e0cff6daeb78475a8d5002c6e431347e
Autor:
Manuel Rhiel, Kerstin Geiger, Geoffroy Andrieux, Julia Rositzka, Melanie Boerries, Toni Cathomen, Tatjana I. Cornu
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Transcription activator-like effector nucleases (TALENs) are programmable nucleases that have entered the clinical stage. Each subunit of the dimer consists of a DNA-binding domain composed of an array of TALE repeats fused to the catalytically activ
Externí odkaz:
https://doaj.org/article/cdd565ffee514bbdabc0f8daa0adbfe8