Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Geoffrey Wells"'
Autor:
Andrew W. See, Patrick Bowden, Geoffrey Wells, Sree Appu, Nathan Lawrentschuk, Peter Liodakis, Chloe Pandeli, Yolanda Aarons, Lloyd M. L. Smyth, Dean P. McKenzie
Publikováno v:
Radiation Oncology, Vol 17, Iss 1, Pp 1-10 (2022)
Abstract Background Dose-escalation to above 80 Gy during external beam radiotherapy for localised prostate cancer leads to improved oncological outcomes but also substantially increased rectal toxicity. The aim of this study was to demonstrate the s
Externí odkaz:
https://doaj.org/article/e673c3a3b4f2460bae153c915b2c8584
Autor:
Yuta Horie, Takafumi Suzuki, Jin Inoue, Tatsuro Iso, Geoffrey Wells, Terry W. Moore, Tsunehiro Mizushima, Albena T. Dinkova-Kostova, Takuma Kasai, Takashi Kamei, Seizo Koshiba, Masayuki Yamamoto
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Using NMR spectroscopy, Horie, Suzuki, Inoue et al. show that the dissociation of Keap1 from Nrf2, or the Hinge-Latch mechanism, is triggered by Keap1-Nrf2 inhibitors and occurs during p62- mediated Nrf2 activation, but not by electrophilic Nrf2 indu
Externí odkaz:
https://doaj.org/article/b744783a8c5b4f278122faa72d2167f4
Autor:
Kavit H. S. Main, James I. Provan, Philip J. Haynes, Geoffrey Wells, John A. Hartley, Alice L. B. Pyne
Publikováno v:
APL Bioengineering, Vol 5, Iss 3, Pp 031504-031504-16 (2021)
Atomic force microscopy (AFM) is a powerful imaging technique that allows for structural characterization of single biomolecules with nanoscale resolution. AFM has a unique capability to image biological molecules in their native states under physiol
Externí odkaz:
https://doaj.org/article/2fef5aafeba84c0581050f0299fa6718
Publikováno v:
International Journal of Society, Culture and Language, Vol 5, Iss 1, Pp 68-81 (2017)
The principles and practice of sustainability have gained momentum in the last 15 years and now form a central part of conversations around social praxis and the future. It has been proposed that the theories driving sustainability science are embedd
Externí odkaz:
https://doaj.org/article/72b60598a2ad4d69bec0aec268684dac
Autor:
Geoffrey Wells
Publikováno v:
Locke Studies, Vol 18, Iss 1 (2018)
A review of D.C. Schindler's recent book Freedom from Reality: The Diabolical Character of Modern Liberty (Notre Dame: University of Notre Dame Press, 2017).
Externí odkaz:
https://doaj.org/article/fcadd4ccf6754931b4618e1e1813c720
Autor:
Fiona Kerr, Oyinkan Sofola-Adesakin, Dobril K Ivanov, Jemma Gatliff, Beatriz Gomez Perez-Nievas, Hélène C Bertrand, Pedro Martinez, Rebecca Callard, Inge Snoeren, Helena M Cochemé, Jennifer Adcott, Mobina Khericha, Jorge Iván Castillo-Quan, Geoffrey Wells, Wendy Noble, Janet Thornton, Linda Partridge
Publikováno v:
PLoS Genetics, Vol 13, Iss 3, p e1006593 (2017)
Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer's disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway ove
Externí odkaz:
https://doaj.org/article/0da1b265333b4d3d89cda4194d8f09d6
Publikováno v:
ARKIVOC, Vol 2000, Iss 5, Pp 779-797 (2000)
Externí odkaz:
https://doaj.org/article/ed11c99727ae4137addaf50f5d8d5bad
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50125 (2012)
Multifunctional trans-cinnamaldehyde (CA) and its analogs display anti-cancer properties, with 2-benzoyloxycinnamaldehyde (BCA) and 5-fluoro-2-hydroxycinnamaldehyde (FHCA) being identified as the ortho-substituted analogs that possess potent anti-tum
Externí odkaz:
https://doaj.org/article/b5d5d33cc80e42cf9c4d306459f2a5a7
Autor:
Lindsay Ferguson, Nasrin Shokrzadeh Madieh, Alexandra Vaideanu, Andreas Schatzlein, Joseph Festa, Harprit Singh, Geoffrey Wells, Sanjib Bhakta, Federico Brucoli
Publikováno v:
Chemical Biology & Drug Design. 101:340-349
open access article A series of 12 novel polyethylene-glycol(PEG)-alkynyl C2-adenosine(ADN) conjugates were synthesized using a robust Sonogashira coupling protocol and characterized by NMR spectroscopy and mass spectrometry analysis. The ADN-PEG con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d785d30f8f5c26573146bd3e25232b7a
https://doi.org/10.1111/cbdd.14128
https://doi.org/10.1111/cbdd.14128
Autor:
Anda Trifan, Defne Gorgun, Michael Salim, Zongyi Li, Alexander Brace, Maxim Zvyagin, Heng Ma, Austin Clyde, David Clark, David J Hardy, Tom Burnley, Lei Huang, John McCalpin, Murali Emani, Hyenseung Yoo, Junqi Yin, Aristeidis Tsaris, Vishal Subbiah, Tanveer Raza, Jessica Liu, Noah Trebesch, Geoffrey Wells, Venkatesh Mysore, Thomas Gibbs, James Phillips, S Chakra Chennubhotla, Ian Foster, Rick Stevens, Anima Anandkumar, Venkatram Vishwanath, John E Stone, Emad Tajkhorshid, Sarah A Harris, Arvind Ramanathan
Publikováno v:
The International Journal of High Performance Computing Applications. 36:603-623
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) replication transcription complex (RTC) is a multi-domain protein responsible for replicating and transcribing the viral mRNA inside a human cell. Attacking RTC function with pharmaceut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faee1bb3ad255746c2c9936d47964798
https://doi.org/10.1177/10943420221113513
https://doi.org/10.1177/10943420221113513