Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Geoffrey W. Tregear"'
Autor:
Qi Xu, Chrishan S. Samuel, Xiao-Jun Du, Xiao-Ming Gao, Geoffrey W. Tregear, Ross A. D. Bathgate, Chongxin Zhao, Ziqiu Ming, Sofia Cendrawan, Helen Kiriazis
Publikováno v:
Laboratory Investigation. 91:675-690
In the setting of myocardial infarction (MI), implanted stem cell viability is low and scar formation limits stem cell homing, viability, and integration. Thus, interventions that favorably remodel fibrotic healing may benefit stem cell therapies. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881a93fe97545ed4e1452a5d4358fea0
https://doi.org/10.1038/labinvest.2010.198
https://doi.org/10.1038/labinvest.2010.198
Publikováno v:
Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry. 11:40-47
Insulin is a circulating peptide hormone that is best known as a critical regulator of glucose levels. It consists of two peptide chains (A and B) that are held together by two disulfide bonds and a third within the A-chain. The first mile- stone ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff7f698e75e895cc57f604c5abe40ab6
https://doi.org/10.2174/187152211794519412
https://doi.org/10.2174/187152211794519412
Autor:
Alessia Belgi, Amy R. Blair, Linda Chan, Mohammed Akhter Hossain, Geoffrey W. Tregear, Chris Belyea, Fazel Shabanpoor, Hue-Trung Truong, Feng Lin, Sofianos Andrikopoulos, Suode Zhang, John D. Wade
Publikováno v:
Bioconjugate Chemistry. 20:1390-1396
Solid-phase peptide synthesis has been refined to a stage where efficient preparation of long and complex peptides is now achievable. However, the postsynthesis handling of poorly soluble peptides often remains a significant hindrance to their purifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163248ac194d71c1506d7f522fb2cfa6
https://doi.org/10.1021/bc900181a
https://doi.org/10.1021/bc900181a
Autor:
Michelle L. Halls, Roger J. Summers, Elaine G.Y. Chew, Geoffrey W. Tregear, Ross A. D. Bathgate, Ishanee Mookerjee, Tim D. Hewitson, Chrishan S. Samuel
Publikováno v:
Annals of the New York Academy of Sciences. 1160:294-299
Derived from fibroblasts, myofibroblasts are the principal cells that are responsible for the synthesis and reorganization of excess matrix in renal interstitial fibrosis. Recognized from their de novo expression of alpha-smooth muscle actin, myofibr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cf0d5032e82ec14bc721405aa518c1
https://doi.org/10.1111/j.1749-6632.2008.03823.x
https://doi.org/10.1111/j.1749-6632.2008.03823.x
Autor:
Edna D. Lekgabe, Ross A. D. Bathgate, Chrishan S. Samuel, Qi Xu, Xiao-Jun Du, Xiao-Ming Gao, Geoffrey W. Tregear, Anthony M. Dart, Helen Kiriazis, Xiao-Lei Moore
Publikováno v:
Annals of the New York Academy of Sciences. 1160:278-284
As a hallmark of heart disease, cardiac fibrosis contributes to the development of heart failure and arrhythmias and forms a key therapeutic target. There is a major unmet need for selective, potent, and safe antifibrotic drugs. Earlier studies revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::120f047f6fba52e22a80568f93e2f60b
https://doi.org/10.1111/j.1749-6632.2008.03780.x
https://doi.org/10.1111/j.1749-6632.2008.03780.x
Autor:
Katayoun Sedaghat, Steve W. Sutton, Craig M. Smith, Timothy W. Lovenberg, David Finkelstein, Andrew J Lawrence, Sherie Ma, Changlu Liu, John D. Wade, Andrew L. Gundlach, Loretta Piccenna, Qian Sang, Pascal Bonaventure, Ross A. D. Bathgate, Geoffrey W. Tregear, Pei Juan Shen
Publikováno v:
Annals of the New York Academy of Sciences. 1160:226-235
As a foundation for regulatory and functional studies of central relaxin family peptide receptor systems, we are mapping the distribution of the different receptors in the brain of rat, mouse, and nonhuman primates, attempting to identify the nature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::571b77edfbcfe15eadbfa0205839f48f
https://doi.org/10.1111/j.1749-6632.2009.03956.x
https://doi.org/10.1111/j.1749-6632.2009.03956.x
Autor:
Feng Lin, Fazel Shabanpoor, John D. Wade, M. Akhter Hossain, Suode Zhang, Geoffrey W. Tregear
Publikováno v:
Annals of the New York Academy of Sciences. 1160:11-15
Successful methods for the chemical assembly of insulin-like peptides allow the detailed study of their structure and function relationships. However, the two-chain, three-disulfide bond structure of this family of peptides, which includes relaxin, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c096a12afd81175b013cfd073b6ed87b
https://doi.org/10.1111/j.1749-6632.2009.03951.x
https://doi.org/10.1111/j.1749-6632.2009.03951.x
Autor:
Yu Rebecca Miao, Chrishan S. Samuel, Mimi L.K. Tang, Melissa Lee, Simon G. Royce, Geoffrey W. Tregear
Publikováno v:
Endocrinology. 150:2692-2699
Mice deficient in the antifibrotic hormone relaxin develop structural changes in the airway that resemble airway remodeling, and demonstrate exaggerated remodeling changes in models of allergic airways disease (AAD). Relaxin expression in asthma has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada7df730e3f84bc0a3bddff8584d141
https://doi.org/10.1210/en.2008-1457
https://doi.org/10.1210/en.2008-1457
Autor:
Ross A. D. Bathgate, Suode Zhang, Mohammed Akhter Hossain, John D. Wade, Fazel Shabanpoor, K. Johan Rosengren, Geoffrey W. Tregear, Feng Lin
Publikováno v:
Chemical Biology & Drug Design. 73:46-52
Relaxin-3, a member of the insulin superfamily, is involved in regulating stress and feeding behavior. It is highly expressed in the brain and is the endogenous ligand for the receptor RXFP3. As relaxin-3 also interacts with the relaxin receptor RXFP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347028bb3bcc3c3e9abf00cfdb15c580
https://doi.org/10.1111/j.1747-0285.2008.00756.x
https://doi.org/10.1111/j.1747-0285.2008.00756.x
Autor:
Michelle L. Halls, Chrishan S. Samuel, Ross A. D. Bathgate, Ishanee Mookerjee, Tim D. Hewitson, Michael L. Mathai, Geoffrey W. Tregear, Roger J. Summers
Publikováno v:
The FASEB Journal. 23:1219-1229
The hormone relaxin inhibits renal myofibroblast differentiation by interfering with TGF-beta1/Smad2 signaling. However, the pathways involved in the relaxin-TGF-beta1/Smad2 interaction remain unknown. This study investigated the signaling mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d44004a781532a825bee10cb2158f59
https://doi.org/10.1096/fj.08-120857
https://doi.org/10.1096/fj.08-120857